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The emerging role of GATA transcription factors in development and disease.

Lentjes MH, Niessen HE, Akiyama Y, de Bruïne AP, Melotte V, van Engeland M - Expert Rev Mol Med (2016)

Bottom Line: The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes.GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system.GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.

ABSTRACT
The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

No MeSH data available.


Related in: MedlinePlus

Overview of GATA1-6 proteins. The GATA proteins are depicted in the upper part of thefigure. The GATA proteins are aligned according to the location of the zinc fingers(ZNI and ZNII). The exon boundaries are depicted above the protein structure. ForGATA4 the TADI and TADII are shown. In the lower part of the figure the regions aroundthe zinc fingers are enlarged, with the correspondingAA numbers written next to theGATA sequence. Posttranslational modification (post-transciptional modification) sitesand disease-associated alterations are marked on top of the corresponding AA. AA,amino acid; TAD, transcriptional activation domains.
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fig01: Overview of GATA1-6 proteins. The GATA proteins are depicted in the upper part of thefigure. The GATA proteins are aligned according to the location of the zinc fingers(ZNI and ZNII). The exon boundaries are depicted above the protein structure. ForGATA4 the TADI and TADII are shown. In the lower part of the figure the regions aroundthe zinc fingers are enlarged, with the correspondingAA numbers written next to theGATA sequence. Posttranslational modification (post-transciptional modification) sitesand disease-associated alterations are marked on top of the corresponding AA. AA,amino acid; TAD, transcriptional activation domains.

Mentions: In vertebrates, six GATA transcription factors have been identified. Based on phylogeneticanalysis and tissue expression profiles, the GATA family can be divided into twosubfamilies, GATA1/2/3 and GATA4/5/6 (Ref. 1).Although in non-vertebrates GATA genes are linked together ontochromosomes, in humans they are segregated onto six distinct chromosomal regions (Table 1), indicating segregation during evolution(Ref. 2). Most GATA genes encodefor several transcripts and protein isoforms. GATA proteins have two zinc finger DNA bindingdomains, Cys-X2-C-X17-Cys-X2-Cys (ZNI and ZNII), whichrecognise the sequences (A/T)GATA(A/G) (Fig. 1)(Ref. 3). Amongst the six GATA binding proteins, thezinc finger domains are more than 70% conserved, while the sequences of the amino-terminaland carboxyl-terminal domains exhibit lower similarity (Ref. 4). In non-vertebrates GATA transcription factors have been identifiedthat contain mostly one zinc finger, i.e. in Drosophila melanogaster andCaenorhabditis elegans (Ref. 3).The C-terminal zinc finger (ZNII) exists in both vertebrates and non-vertebrates indicatingthat ZNI was duplicated from ZNII (Ref. 2). Figure 1.


The emerging role of GATA transcription factors in development and disease.

Lentjes MH, Niessen HE, Akiyama Y, de Bruïne AP, Melotte V, van Engeland M - Expert Rev Mol Med (2016)

Overview of GATA1-6 proteins. The GATA proteins are depicted in the upper part of thefigure. The GATA proteins are aligned according to the location of the zinc fingers(ZNI and ZNII). The exon boundaries are depicted above the protein structure. ForGATA4 the TADI and TADII are shown. In the lower part of the figure the regions aroundthe zinc fingers are enlarged, with the correspondingAA numbers written next to theGATA sequence. Posttranslational modification (post-transciptional modification) sitesand disease-associated alterations are marked on top of the corresponding AA. AA,amino acid; TAD, transcriptional activation domains.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836206&req=5

fig01: Overview of GATA1-6 proteins. The GATA proteins are depicted in the upper part of thefigure. The GATA proteins are aligned according to the location of the zinc fingers(ZNI and ZNII). The exon boundaries are depicted above the protein structure. ForGATA4 the TADI and TADII are shown. In the lower part of the figure the regions aroundthe zinc fingers are enlarged, with the correspondingAA numbers written next to theGATA sequence. Posttranslational modification (post-transciptional modification) sitesand disease-associated alterations are marked on top of the corresponding AA. AA,amino acid; TAD, transcriptional activation domains.
Mentions: In vertebrates, six GATA transcription factors have been identified. Based on phylogeneticanalysis and tissue expression profiles, the GATA family can be divided into twosubfamilies, GATA1/2/3 and GATA4/5/6 (Ref. 1).Although in non-vertebrates GATA genes are linked together ontochromosomes, in humans they are segregated onto six distinct chromosomal regions (Table 1), indicating segregation during evolution(Ref. 2). Most GATA genes encodefor several transcripts and protein isoforms. GATA proteins have two zinc finger DNA bindingdomains, Cys-X2-C-X17-Cys-X2-Cys (ZNI and ZNII), whichrecognise the sequences (A/T)GATA(A/G) (Fig. 1)(Ref. 3). Amongst the six GATA binding proteins, thezinc finger domains are more than 70% conserved, while the sequences of the amino-terminaland carboxyl-terminal domains exhibit lower similarity (Ref. 4). In non-vertebrates GATA transcription factors have been identifiedthat contain mostly one zinc finger, i.e. in Drosophila melanogaster andCaenorhabditis elegans (Ref. 3).The C-terminal zinc finger (ZNII) exists in both vertebrates and non-vertebrates indicatingthat ZNI was duplicated from ZNII (Ref. 2). Figure 1.

Bottom Line: The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes.GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system.GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology,GROW - School for Oncology and Developmental Biology,Maastricht University Medical Center,Maastricht,The Netherlands.

ABSTRACT
The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

No MeSH data available.


Related in: MedlinePlus