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Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis.

Duan L, Hu X, Jin Y, Liu R, You Q - BMC Cancer (2016)

Bottom Line: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria.Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).Higher expression of survivin in NSCLC patients was found when compared to normal controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. liangduanplos@163.com.

ABSTRACT

Background: Surviving expression might serve as a prognostic biomarker predicting the clinical outcome of non-small cell lung cancer (NSCLC). The study was conducted to explore the potential correlation of survivin protein expression with NSCLC and its clinicopathologic characteristics.

Methods: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria. Data was extracted from these articles and all statistical analysis was conducted by using Stata 12.0.

Results: A total of 28 literatures (14 studies in Chinese and 14 studies in English) were enrolled in this meta-analysis, including 3206 NSCLC patients and 816 normal controls. The result of meta-analysis demonstrated a significant difference of survivin positive expression between NSCLC patients and normal controls (RR = 7.16, 95 % CI = 4.63-11.07, P < 0.001). To investigate the relationship of survivin expression and clinicopathologic characteristics, we performed a meta-analysis in NSCLC patients. Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).

Conclusion: Higher expression of survivin in NSCLC patients was found when compared to normal controls. Survivin expression was associated with the clinicopathologic characteristics of NSCLC and may serves as an important biomarker for NSCLC progression.

No MeSH data available.


Related in: MedlinePlus

Forest plots for the comparisons of survivin expression between patients at TNM I/II stage and TNM III/IV stage
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Fig5: Forest plots for the comparisons of survivin expression between patients at TNM I/II stage and TNM III/IV stage

Mentions: For the meta-analysis according to pathological types, we included 22 studies, involving 1010 SCC patients and 806 AC patients. Heterogeneity test revealed the lack of heterogeneity in these studies and a fixed-effect model was applied (I2 = 7 %, P = 0.367). No significantly different survivin expression was found between squamous cell carcinoma (SCC) and adenocarcinoma (AC) (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983) (Fig. 3). A total of 21 studies investigated histological differentiation of NSCLC patients and moderate heterogeneity existed in these studies (I2 = 45.4 %, P = 0.013). Results from random-effect model suggested that survivin expression was significantly lower in NSCLC patients with well/moderate differentiation than that in the patients with poor differentiation (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001) (Fig. 4). 26 studies provided survivin expression level at different TNM stages. Heterogeneity test showed the presence of heterogeneity in these studies (I2 = 72.7 %, P < 0.001). Meta-analysis results revealed that NSCLC patients at TNM III/IV stage had a significantly higher survivin expression than the patients at TNM I/II stage (RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001) (Fig. 5). A total of 25 studies indicated the status of lymphatic metastasis. Meta-analysis suggested that survivin expression in NSCLC patients with lymphatic metastasis was significantly higher than that in the patients without lymphatic metastasis (RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035) (Fig. 6). 11 studies showed the survivin expression in the patient with different tumor size. No heterogeneity was found in these studies (I2 = 18.1 %, P = 0.272). Meta-analysis revealed that survivin expression was not associated with tumor size (RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336) (Fig. 7).Fig. 3


Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis.

Duan L, Hu X, Jin Y, Liu R, You Q - BMC Cancer (2016)

Forest plots for the comparisons of survivin expression between patients at TNM I/II stage and TNM III/IV stage
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4836165&req=5

Fig5: Forest plots for the comparisons of survivin expression between patients at TNM I/II stage and TNM III/IV stage
Mentions: For the meta-analysis according to pathological types, we included 22 studies, involving 1010 SCC patients and 806 AC patients. Heterogeneity test revealed the lack of heterogeneity in these studies and a fixed-effect model was applied (I2 = 7 %, P = 0.367). No significantly different survivin expression was found between squamous cell carcinoma (SCC) and adenocarcinoma (AC) (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983) (Fig. 3). A total of 21 studies investigated histological differentiation of NSCLC patients and moderate heterogeneity existed in these studies (I2 = 45.4 %, P = 0.013). Results from random-effect model suggested that survivin expression was significantly lower in NSCLC patients with well/moderate differentiation than that in the patients with poor differentiation (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001) (Fig. 4). 26 studies provided survivin expression level at different TNM stages. Heterogeneity test showed the presence of heterogeneity in these studies (I2 = 72.7 %, P < 0.001). Meta-analysis results revealed that NSCLC patients at TNM III/IV stage had a significantly higher survivin expression than the patients at TNM I/II stage (RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001) (Fig. 5). A total of 25 studies indicated the status of lymphatic metastasis. Meta-analysis suggested that survivin expression in NSCLC patients with lymphatic metastasis was significantly higher than that in the patients without lymphatic metastasis (RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035) (Fig. 6). 11 studies showed the survivin expression in the patient with different tumor size. No heterogeneity was found in these studies (I2 = 18.1 %, P = 0.272). Meta-analysis revealed that survivin expression was not associated with tumor size (RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336) (Fig. 7).Fig. 3

Bottom Line: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria.Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).Higher expression of survivin in NSCLC patients was found when compared to normal controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. liangduanplos@163.com.

ABSTRACT

Background: Surviving expression might serve as a prognostic biomarker predicting the clinical outcome of non-small cell lung cancer (NSCLC). The study was conducted to explore the potential correlation of survivin protein expression with NSCLC and its clinicopathologic characteristics.

Methods: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria. Data was extracted from these articles and all statistical analysis was conducted by using Stata 12.0.

Results: A total of 28 literatures (14 studies in Chinese and 14 studies in English) were enrolled in this meta-analysis, including 3206 NSCLC patients and 816 normal controls. The result of meta-analysis demonstrated a significant difference of survivin positive expression between NSCLC patients and normal controls (RR = 7.16, 95 % CI = 4.63-11.07, P < 0.001). To investigate the relationship of survivin expression and clinicopathologic characteristics, we performed a meta-analysis in NSCLC patients. Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).

Conclusion: Higher expression of survivin in NSCLC patients was found when compared to normal controls. Survivin expression was associated with the clinicopathologic characteristics of NSCLC and may serves as an important biomarker for NSCLC progression.

No MeSH data available.


Related in: MedlinePlus