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Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis.

Duan L, Hu X, Jin Y, Liu R, You Q - BMC Cancer (2016)

Bottom Line: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria.Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).Higher expression of survivin in NSCLC patients was found when compared to normal controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. liangduanplos@163.com.

ABSTRACT

Background: Surviving expression might serve as a prognostic biomarker predicting the clinical outcome of non-small cell lung cancer (NSCLC). The study was conducted to explore the potential correlation of survivin protein expression with NSCLC and its clinicopathologic characteristics.

Methods: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria. Data was extracted from these articles and all statistical analysis was conducted by using Stata 12.0.

Results: A total of 28 literatures (14 studies in Chinese and 14 studies in English) were enrolled in this meta-analysis, including 3206 NSCLC patients and 816 normal controls. The result of meta-analysis demonstrated a significant difference of survivin positive expression between NSCLC patients and normal controls (RR = 7.16, 95 % CI = 4.63-11.07, P < 0.001). To investigate the relationship of survivin expression and clinicopathologic characteristics, we performed a meta-analysis in NSCLC patients. Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).

Conclusion: Higher expression of survivin in NSCLC patients was found when compared to normal controls. Survivin expression was associated with the clinicopathologic characteristics of NSCLC and may serves as an important biomarker for NSCLC progression.

No MeSH data available.


Related in: MedlinePlus

Forest plots for the comparisons of survivin expression between NSCLC patients and normal controls
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Fig2: Forest plots for the comparisons of survivin expression between NSCLC patients and normal controls

Mentions: A total of 19 studies provided data of survivin expression in NSCLC patients and normal controls (1537 NSCLC patients and 816 normal controls). Heterogeneity test revealed the existence of heterogeneity in those 19 trials, thus a random-effect model was used (I2 = 58.1 %, P < 0.001). Meta-analysis result revealed that survivin expression in NSCLC patients was significantly higher when compared with normal controls (RR = 7.16, 95 % CI = 4.63-11.07, P < 0.001) (Fig. 2).Fig. 2


Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis.

Duan L, Hu X, Jin Y, Liu R, You Q - BMC Cancer (2016)

Forest plots for the comparisons of survivin expression between NSCLC patients and normal controls
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4836165&req=5

Fig2: Forest plots for the comparisons of survivin expression between NSCLC patients and normal controls
Mentions: A total of 19 studies provided data of survivin expression in NSCLC patients and normal controls (1537 NSCLC patients and 816 normal controls). Heterogeneity test revealed the existence of heterogeneity in those 19 trials, thus a random-effect model was used (I2 = 58.1 %, P < 0.001). Meta-analysis result revealed that survivin expression in NSCLC patients was significantly higher when compared with normal controls (RR = 7.16, 95 % CI = 4.63-11.07, P < 0.001) (Fig. 2).Fig. 2

Bottom Line: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria.Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).Higher expression of survivin in NSCLC patients was found when compared to normal controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. liangduanplos@163.com.

ABSTRACT

Background: Surviving expression might serve as a prognostic biomarker predicting the clinical outcome of non-small cell lung cancer (NSCLC). The study was conducted to explore the potential correlation of survivin protein expression with NSCLC and its clinicopathologic characteristics.

Methods: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria. Data was extracted from these articles and all statistical analysis was conducted by using Stata 12.0.

Results: A total of 28 literatures (14 studies in Chinese and 14 studies in English) were enrolled in this meta-analysis, including 3206 NSCLC patients and 816 normal controls. The result of meta-analysis demonstrated a significant difference of survivin positive expression between NSCLC patients and normal controls (RR = 7.16, 95 % CI = 4.63-11.07, P < 0.001). To investigate the relationship of survivin expression and clinicopathologic characteristics, we performed a meta-analysis in NSCLC patients. Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).

Conclusion: Higher expression of survivin in NSCLC patients was found when compared to normal controls. Survivin expression was associated with the clinicopathologic characteristics of NSCLC and may serves as an important biomarker for NSCLC progression.

No MeSH data available.


Related in: MedlinePlus