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Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis.

Duan L, Hu X, Jin Y, Liu R, You Q - BMC Cancer (2016)

Bottom Line: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria.Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).Higher expression of survivin in NSCLC patients was found when compared to normal controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. liangduanplos@163.com.

ABSTRACT

Background: Surviving expression might serve as a prognostic biomarker predicting the clinical outcome of non-small cell lung cancer (NSCLC). The study was conducted to explore the potential correlation of survivin protein expression with NSCLC and its clinicopathologic characteristics.

Methods: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria. Data was extracted from these articles and all statistical analysis was conducted by using Stata 12.0.

Results: A total of 28 literatures (14 studies in Chinese and 14 studies in English) were enrolled in this meta-analysis, including 3206 NSCLC patients and 816 normal controls. The result of meta-analysis demonstrated a significant difference of survivin positive expression between NSCLC patients and normal controls (RR = 7.16, 95 % CI = 4.63-11.07, P < 0.001). To investigate the relationship of survivin expression and clinicopathologic characteristics, we performed a meta-analysis in NSCLC patients. Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).

Conclusion: Higher expression of survivin in NSCLC patients was found when compared to normal controls. Survivin expression was associated with the clinicopathologic characteristics of NSCLC and may serves as an important biomarker for NSCLC progression.

No MeSH data available.


Related in: MedlinePlus

PRISMA Flow chart of study selection procedure
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Fig1: PRISMA Flow chart of study selection procedure

Mentions: Four hundred and eighty-seven articles were initially identified through database searches. Twenty-eight studies remained after excluding duplicates (n = 42), letters, reviews, meta-analyses (n = 46) and irrelevant topic (n = 273), non-core journal in Chinese (n = 36), insufficient information in studies (n = 35) and number of NSCLC cases less than 60 (n = 27), 28 trials were finally selected for this meta-analysis (Fig. 1) [5, 10–36]. The enrolled studies published between 2005 and 2015 included 3206 NSCLC patients and 816 normal controls, with 2252 males and 954 females. For the pathological type, 1010 patients with squamous cell carcinoma (SCC), 806 with adenocarcinoma (AC). With respect to clinicopathologic features, 1198 patients with well/moderate differentiation, 788 with poor differentiation; 1421 at I/II stage and 1009 at III/IV stage (TNM stage); 1256 patients with lymphatic metastasis and 1185 patients without lymphatic metastasis. All included studies scored 7 in terms of NOS scores. The baseline characteristics of included studies were showed in Table 1.Fig. 1


Survivin protein expression is involved in the progression of non-small cell lung cancer in Asians: a meta-analysis.

Duan L, Hu X, Jin Y, Liu R, You Q - BMC Cancer (2016)

PRISMA Flow chart of study selection procedure
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4836165&req=5

Fig1: PRISMA Flow chart of study selection procedure
Mentions: Four hundred and eighty-seven articles were initially identified through database searches. Twenty-eight studies remained after excluding duplicates (n = 42), letters, reviews, meta-analyses (n = 46) and irrelevant topic (n = 273), non-core journal in Chinese (n = 36), insufficient information in studies (n = 35) and number of NSCLC cases less than 60 (n = 27), 28 trials were finally selected for this meta-analysis (Fig. 1) [5, 10–36]. The enrolled studies published between 2005 and 2015 included 3206 NSCLC patients and 816 normal controls, with 2252 males and 954 females. For the pathological type, 1010 patients with squamous cell carcinoma (SCC), 806 with adenocarcinoma (AC). With respect to clinicopathologic features, 1198 patients with well/moderate differentiation, 788 with poor differentiation; 1421 at I/II stage and 1009 at III/IV stage (TNM stage); 1256 patients with lymphatic metastasis and 1185 patients without lymphatic metastasis. All included studies scored 7 in terms of NOS scores. The baseline characteristics of included studies were showed in Table 1.Fig. 1

Bottom Line: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria.Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).Higher expression of survivin in NSCLC patients was found when compared to normal controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. liangduanplos@163.com.

ABSTRACT

Background: Surviving expression might serve as a prognostic biomarker predicting the clinical outcome of non-small cell lung cancer (NSCLC). The study was conducted to explore the potential correlation of survivin protein expression with NSCLC and its clinicopathologic characteristics.

Methods: PubMed, Medline, Cochrane Library, CNKI and Wanfang database were searched through January 2016 with a set of inclusion and exclusion criteria. Data was extracted from these articles and all statistical analysis was conducted by using Stata 12.0.

Results: A total of 28 literatures (14 studies in Chinese and 14 studies in English) were enrolled in this meta-analysis, including 3206 NSCLC patients and 816 normal controls. The result of meta-analysis demonstrated a significant difference of survivin positive expression between NSCLC patients and normal controls (RR = 7.16, 95 % CI = 4.63-11.07, P < 0.001). To investigate the relationship of survivin expression and clinicopathologic characteristics, we performed a meta-analysis in NSCLC patients. Our results indicates survivin expression was associated with histological differentiation, tumor-node-metastasis (TNM) stage and lymph node metastasis (LNM) (RR = 0.80, 95 % CI = 0.73-0.87, P < 0.001; RR = 0.75, 95 % CI = 0.67-0.84, P < 0.001; RR = 1.14, 95 % CI = 1.01-1.29, P = 0.035, respectively), but not pathological type and tumor size. (RR = 1.00, 95 % CI = 0.93-1.07, P = 0.983; RR = 0.95, 95 % CI = 0.86-1.05, P = 0.336, respectively).

Conclusion: Higher expression of survivin in NSCLC patients was found when compared to normal controls. Survivin expression was associated with the clinicopathologic characteristics of NSCLC and may serves as an important biomarker for NSCLC progression.

No MeSH data available.


Related in: MedlinePlus