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Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder.

Nagai T, Naiki T, Kawai N, Iida K, Etani T, Ando R, Hamamoto S, Sugiyama Y, Okada A, Mizuno K, Umemoto Y, Yasui T - Case Rep Oncol (2016)

Bottom Line: The final pathological diagnosis was a lymphoepithelioma-like variant of urothelial carcinoma with perivesical soft tissue invasion.The patient subsequently became free of cancer 72 months postoperatively.This suggests that measuring the ADC value of a lymphoepithelioma-like carcinoma prior to operation may be helpful in predicting LELCB.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

ABSTRACT
Lymphoepithelioma-like carcinoma of the urinary bladder (LELCB) is a rare variant of infiltrating urothelial carcinoma. We report a case of LELCB in a 43-year-old man. Ultrasonography and cystoscopy revealed two bladder tumors, one on the left side of the trigone and the other on the right side of the trigone. Transurethral resection of the bladder tumors was performed and pathological analysis revealed undifferentiated carcinoma. We therefore performed radical cystectomy and urinary diversion. Immunohistochemically the tumor cells were positive for cytokeratin, but negative for Epstein-Barr virus-encoded small RNA in situ hybridization as found for previous cases of LELCB. The final pathological diagnosis was a lymphoepithelioma-like variant of urothelial carcinoma with perivesical soft tissue invasion. For adjuvant systemic chemotherapy, three courses of cisplatin were administered. The patient subsequently became free of cancer 72 months postoperatively. Based on the literature, pure or predominant LELCB types show favorable prognoses due to their sensitivity to chemotherapy or radiotherapy. An analysis of the apparent diffusion coefficient (ADC) values of bladder tumors examined in our institution revealed that the ADC value measured for this LELCB was relatively low compared to conventional urothelial carcinomas. This suggests that measuring the ADC value of a lymphoepithelioma-like carcinoma prior to operation may be helpful in predicting LELCB.

No MeSH data available.


Related in: MedlinePlus

a MRI (T2-enhanced, coronal image) showing two bladder tumors, one on the left side of trigone (arrowhead) and the other on the right side of the trigone (arrow). b MRI (T2-enhanced, sagittal image) showing a bladder tumor on the left side of the trigone (arrowhead) and perivesical soft tissue invasion. c The average value of the ADC of the tumor was 782 × 10−3 mm2/s.
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Figure 1: a MRI (T2-enhanced, coronal image) showing two bladder tumors, one on the left side of trigone (arrowhead) and the other on the right side of the trigone (arrow). b MRI (T2-enhanced, sagittal image) showing a bladder tumor on the left side of the trigone (arrowhead) and perivesical soft tissue invasion. c The average value of the ADC of the tumor was 782 × 10−3 mm2/s.

Mentions: A 43-year-old Japanese man presented to our department complaining of frequent urination. He had no prior personal or family medical history of this complaint. There were no notable findings in blood tests and chest radiography. Urine cytology results were negative. On cystoscopy, two bladder tumors were observed, one on the left side of the trigone and the other on the right side of the trigone. A total body computed tomography (CT) scan was performed and the presence of distant metastases or lymph node involvement was excluded. MRI revealed that the tumor on the left side of the trigone had invaded the perivesical soft tissue of the bladder, but not the prostate or seminal vesicles (fig. 1a, b).


Pure Lymphoepithelioma-Like Carcinoma Originating from the Urinary Bladder.

Nagai T, Naiki T, Kawai N, Iida K, Etani T, Ando R, Hamamoto S, Sugiyama Y, Okada A, Mizuno K, Umemoto Y, Yasui T - Case Rep Oncol (2016)

a MRI (T2-enhanced, coronal image) showing two bladder tumors, one on the left side of trigone (arrowhead) and the other on the right side of the trigone (arrow). b MRI (T2-enhanced, sagittal image) showing a bladder tumor on the left side of the trigone (arrowhead) and perivesical soft tissue invasion. c The average value of the ADC of the tumor was 782 × 10−3 mm2/s.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836139&req=5

Figure 1: a MRI (T2-enhanced, coronal image) showing two bladder tumors, one on the left side of trigone (arrowhead) and the other on the right side of the trigone (arrow). b MRI (T2-enhanced, sagittal image) showing a bladder tumor on the left side of the trigone (arrowhead) and perivesical soft tissue invasion. c The average value of the ADC of the tumor was 782 × 10−3 mm2/s.
Mentions: A 43-year-old Japanese man presented to our department complaining of frequent urination. He had no prior personal or family medical history of this complaint. There were no notable findings in blood tests and chest radiography. Urine cytology results were negative. On cystoscopy, two bladder tumors were observed, one on the left side of the trigone and the other on the right side of the trigone. A total body computed tomography (CT) scan was performed and the presence of distant metastases or lymph node involvement was excluded. MRI revealed that the tumor on the left side of the trigone had invaded the perivesical soft tissue of the bladder, but not the prostate or seminal vesicles (fig. 1a, b).

Bottom Line: The final pathological diagnosis was a lymphoepithelioma-like variant of urothelial carcinoma with perivesical soft tissue invasion.The patient subsequently became free of cancer 72 months postoperatively.This suggests that measuring the ADC value of a lymphoepithelioma-like carcinoma prior to operation may be helpful in predicting LELCB.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

ABSTRACT
Lymphoepithelioma-like carcinoma of the urinary bladder (LELCB) is a rare variant of infiltrating urothelial carcinoma. We report a case of LELCB in a 43-year-old man. Ultrasonography and cystoscopy revealed two bladder tumors, one on the left side of the trigone and the other on the right side of the trigone. Transurethral resection of the bladder tumors was performed and pathological analysis revealed undifferentiated carcinoma. We therefore performed radical cystectomy and urinary diversion. Immunohistochemically the tumor cells were positive for cytokeratin, but negative for Epstein-Barr virus-encoded small RNA in situ hybridization as found for previous cases of LELCB. The final pathological diagnosis was a lymphoepithelioma-like variant of urothelial carcinoma with perivesical soft tissue invasion. For adjuvant systemic chemotherapy, three courses of cisplatin were administered. The patient subsequently became free of cancer 72 months postoperatively. Based on the literature, pure or predominant LELCB types show favorable prognoses due to their sensitivity to chemotherapy or radiotherapy. An analysis of the apparent diffusion coefficient (ADC) values of bladder tumors examined in our institution revealed that the ADC value measured for this LELCB was relatively low compared to conventional urothelial carcinomas. This suggests that measuring the ADC value of a lymphoepithelioma-like carcinoma prior to operation may be helpful in predicting LELCB.

No MeSH data available.


Related in: MedlinePlus