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A Case of Uveal Colobomas Showing Marked Left-Right Difference in Diabetic Retinopathy.

Moriya T, Ochi R, Imagawa Y, Sato B, Morishita S, Tonari M, Fukumoto M, Suzuki H, Kobayashi T, Kida T, Ikeda T - Case Rep Ophthalmol (2016)

Bottom Line: The colobomatous area in his left eye was less extensive and did not involve the macula.Fluorescein fundus angiography revealed a retinal nonperfusion area only in the left eye, and panretinal photocoagulation was subsequently performed.Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Osaka Kaisei Hospital, Osaka, Japan.

ABSTRACT

Purpose: Congenital uveal colobomas, including inferior iris and choroidal colobomas, are associated with microcornea and microphthalmia and often show left-right differences (laterality). The purpose of this study was to report a case of choroidal coloboma associated with left-right differences in diabetic retinopathy (DR).

Case: This study reports a 59-year-old male with bilateral iris and choroidal colobomas. The colobomatous area in the patient's right eye extended to the macula, and his right eye had been amblyopic since birth. The colobomatous area in his left eye was less extensive and did not involve the macula. Examination of the patient's left eye revealed multiple hemorrhages and hard exudates in the macula due to DR, but examination of his right eye showed almost no changes in DR, thus revealing a marked left-right difference. Optical coherence tomography showed more extensive retinal thinning in the patient's right eye than in his left eye. Fluorescein fundus angiography revealed a retinal nonperfusion area only in the left eye, and panretinal photocoagulation was subsequently performed.

Conclusion: Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.

No MeSH data available.


Related in: MedlinePlus

OCT of the right and left eyes. The right eye (a) shows retinal thinning. The retina is thicker in the left eye (b) than in the right eye, and foveal hard exudates are present.
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Figure 2: OCT of the right and left eyes. The right eye (a) shows retinal thinning. The retina is thicker in the left eye (b) than in the right eye, and foveal hard exudates are present.

Mentions: The fundus also of the left eye showed multiple hemorrhages and marked hard exudates in the macula (fig. 1b). Optical coherence tomography (OCT) imaging of the right eye showed retinal thinning and inferior choroidal coloboma (fig. 2a). OCT of the left eye revealed macular hard exudates and temporal retinal edema, but without retinal thinning (fig. 2b). Fluorescein fundus angiography showed no areas of nonperfusion in the right retina (fig. 3a). In the left retina, except in the inferior choroidal colobomatous area, there were nonperfused areas in the circumferential periphery and contrast leakage over time (fig. 3b). Examination of the vitreous by slit-lamp microscopy with a front lens showed no posterior vitreous detachment (PVD) in either eye.


A Case of Uveal Colobomas Showing Marked Left-Right Difference in Diabetic Retinopathy.

Moriya T, Ochi R, Imagawa Y, Sato B, Morishita S, Tonari M, Fukumoto M, Suzuki H, Kobayashi T, Kida T, Ikeda T - Case Rep Ophthalmol (2016)

OCT of the right and left eyes. The right eye (a) shows retinal thinning. The retina is thicker in the left eye (b) than in the right eye, and foveal hard exudates are present.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836121&req=5

Figure 2: OCT of the right and left eyes. The right eye (a) shows retinal thinning. The retina is thicker in the left eye (b) than in the right eye, and foveal hard exudates are present.
Mentions: The fundus also of the left eye showed multiple hemorrhages and marked hard exudates in the macula (fig. 1b). Optical coherence tomography (OCT) imaging of the right eye showed retinal thinning and inferior choroidal coloboma (fig. 2a). OCT of the left eye revealed macular hard exudates and temporal retinal edema, but without retinal thinning (fig. 2b). Fluorescein fundus angiography showed no areas of nonperfusion in the right retina (fig. 3a). In the left retina, except in the inferior choroidal colobomatous area, there were nonperfused areas in the circumferential periphery and contrast leakage over time (fig. 3b). Examination of the vitreous by slit-lamp microscopy with a front lens showed no posterior vitreous detachment (PVD) in either eye.

Bottom Line: The colobomatous area in his left eye was less extensive and did not involve the macula.Fluorescein fundus angiography revealed a retinal nonperfusion area only in the left eye, and panretinal photocoagulation was subsequently performed.Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Osaka Kaisei Hospital, Osaka, Japan.

ABSTRACT

Purpose: Congenital uveal colobomas, including inferior iris and choroidal colobomas, are associated with microcornea and microphthalmia and often show left-right differences (laterality). The purpose of this study was to report a case of choroidal coloboma associated with left-right differences in diabetic retinopathy (DR).

Case: This study reports a 59-year-old male with bilateral iris and choroidal colobomas. The colobomatous area in the patient's right eye extended to the macula, and his right eye had been amblyopic since birth. The colobomatous area in his left eye was less extensive and did not involve the macula. Examination of the patient's left eye revealed multiple hemorrhages and hard exudates in the macula due to DR, but examination of his right eye showed almost no changes in DR, thus revealing a marked left-right difference. Optical coherence tomography showed more extensive retinal thinning in the patient's right eye than in his left eye. Fluorescein fundus angiography revealed a retinal nonperfusion area only in the left eye, and panretinal photocoagulation was subsequently performed.

Conclusion: Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.

No MeSH data available.


Related in: MedlinePlus