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A Case of Uveal Colobomas Showing Marked Left-Right Difference in Diabetic Retinopathy.

Moriya T, Ochi R, Imagawa Y, Sato B, Morishita S, Tonari M, Fukumoto M, Suzuki H, Kobayashi T, Kida T, Ikeda T - Case Rep Ophthalmol (2016)

Bottom Line: The colobomatous area in his left eye was less extensive and did not involve the macula.Fluorescein fundus angiography revealed a retinal nonperfusion area only in the left eye, and panretinal photocoagulation was subsequently performed.Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Osaka Kaisei Hospital, Osaka, Japan.

ABSTRACT

Purpose: Congenital uveal colobomas, including inferior iris and choroidal colobomas, are associated with microcornea and microphthalmia and often show left-right differences (laterality). The purpose of this study was to report a case of choroidal coloboma associated with left-right differences in diabetic retinopathy (DR).

Case: This study reports a 59-year-old male with bilateral iris and choroidal colobomas. The colobomatous area in the patient's right eye extended to the macula, and his right eye had been amblyopic since birth. The colobomatous area in his left eye was less extensive and did not involve the macula. Examination of the patient's left eye revealed multiple hemorrhages and hard exudates in the macula due to DR, but examination of his right eye showed almost no changes in DR, thus revealing a marked left-right difference. Optical coherence tomography showed more extensive retinal thinning in the patient's right eye than in his left eye. Fluorescein fundus angiography revealed a retinal nonperfusion area only in the left eye, and panretinal photocoagulation was subsequently performed.

Conclusion: Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.

No MeSH data available.


Related in: MedlinePlus

Fundus photography of the right and left eyes. Extensive choroidal coloboma is seen in the right eye (a), markedly different from the left eye (b).
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Figure 1: Fundus photography of the right and left eyes. Extensive choroidal coloboma is seen in the right eye (a), markedly different from the left eye (b).

Mentions: Upon initial examination, the patient's visual acuity (VA) was 0.04 × S-6.00D = C-1.50D A × 80 in his right eye and 0.4 × S-1.75D = C-0.50D A × 150 in his left eye. His intraocular pressure was 16 mm Hg OD and 11 mm Hg OS, and his axial length was 24.8 mm OD and 24.5 mm OS. Slit-lamp examination showed mild-to-moderate nuclear cataracts, and inferior iris colobomas in the optic media were observed in both eyes. Right-eye funduscopy showed an extensive inferior choroidal coloboma that included the optic disc and macula. The fundus showed a tigroid pattern due to myopia, yet presented almost no changes of DR (fig. 1a). Left-eye funduscopy also showed a choroidal coloboma, yet without involvement of the macula. The choroidal coloboma was seen in two areas, both inferiorly and temporo-inferiorly near the optic disc.


A Case of Uveal Colobomas Showing Marked Left-Right Difference in Diabetic Retinopathy.

Moriya T, Ochi R, Imagawa Y, Sato B, Morishita S, Tonari M, Fukumoto M, Suzuki H, Kobayashi T, Kida T, Ikeda T - Case Rep Ophthalmol (2016)

Fundus photography of the right and left eyes. Extensive choroidal coloboma is seen in the right eye (a), markedly different from the left eye (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836121&req=5

Figure 1: Fundus photography of the right and left eyes. Extensive choroidal coloboma is seen in the right eye (a), markedly different from the left eye (b).
Mentions: Upon initial examination, the patient's visual acuity (VA) was 0.04 × S-6.00D = C-1.50D A × 80 in his right eye and 0.4 × S-1.75D = C-0.50D A × 150 in his left eye. His intraocular pressure was 16 mm Hg OD and 11 mm Hg OS, and his axial length was 24.8 mm OD and 24.5 mm OS. Slit-lamp examination showed mild-to-moderate nuclear cataracts, and inferior iris colobomas in the optic media were observed in both eyes. Right-eye funduscopy showed an extensive inferior choroidal coloboma that included the optic disc and macula. The fundus showed a tigroid pattern due to myopia, yet presented almost no changes of DR (fig. 1a). Left-eye funduscopy also showed a choroidal coloboma, yet without involvement of the macula. The choroidal coloboma was seen in two areas, both inferiorly and temporo-inferiorly near the optic disc.

Bottom Line: The colobomatous area in his left eye was less extensive and did not involve the macula.Fluorescein fundus angiography revealed a retinal nonperfusion area only in the left eye, and panretinal photocoagulation was subsequently performed.Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Osaka Kaisei Hospital, Osaka, Japan.

ABSTRACT

Purpose: Congenital uveal colobomas, including inferior iris and choroidal colobomas, are associated with microcornea and microphthalmia and often show left-right differences (laterality). The purpose of this study was to report a case of choroidal coloboma associated with left-right differences in diabetic retinopathy (DR).

Case: This study reports a 59-year-old male with bilateral iris and choroidal colobomas. The colobomatous area in the patient's right eye extended to the macula, and his right eye had been amblyopic since birth. The colobomatous area in his left eye was less extensive and did not involve the macula. Examination of the patient's left eye revealed multiple hemorrhages and hard exudates in the macula due to DR, but examination of his right eye showed almost no changes in DR, thus revealing a marked left-right difference. Optical coherence tomography showed more extensive retinal thinning in the patient's right eye than in his left eye. Fluorescein fundus angiography revealed a retinal nonperfusion area only in the left eye, and panretinal photocoagulation was subsequently performed.

Conclusion: Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.

No MeSH data available.


Related in: MedlinePlus