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Challenges and opportunities of bovine milk analysis by mass spectrometry.

Verma A, Ambatipudi K - Clin Proteomics (2016)

Bottom Line: Although analyses of different milk components (e.g. proteins, lipids) pose huge challenges, the use of mass spectrometric (MS)-based techniques is steadily improving our understanding of the complexity of the biological traits that effect milk yield and its components to meet the global demand arising from population growth.In addition, different milk constituents have various applications in veterinary research and medicine, including early disease diagnosis.The aim of the review is to present an overview of the progress made in MS-based analysis of milk, and suggest a multi-pronged MS strategy to better explore different milk components for translational and clinical utilities.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667 India.

ABSTRACT
Bovine milk and its products (e.g. cheese, yoghurt) are an important part of human diet with beneficial effects for all ages. Although analyses of different milk components (e.g. proteins, lipids) pose huge challenges, the use of mass spectrometric (MS)-based techniques is steadily improving our understanding of the complexity of the biological traits that effect milk yield and its components to meet the global demand arising from population growth. In addition, different milk constituents have various applications in veterinary research and medicine, including early disease diagnosis. The aim of the review is to present an overview of the progress made in MS-based analysis of milk, and suggest a multi-pronged MS strategy to better explore different milk components for translational and clinical utilities.

No MeSH data available.


Schematic representation of the structure of mammary gland. a A general model of udder, b image of udder with complex tissue comprised of many ducts and alveoli, c an alveolus comprising of many cell types such as secretory and intercalating ducts, d an alveolus showing merocrine mode of secretion for protein component of the milk, e an alveolus showing apocrine mode of secretion for lipid component of the milk
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Fig1: Schematic representation of the structure of mammary gland. a A general model of udder, b image of udder with complex tissue comprised of many ducts and alveoli, c an alveolus comprising of many cell types such as secretory and intercalating ducts, d an alveolus showing merocrine mode of secretion for protein component of the milk, e an alveolus showing apocrine mode of secretion for lipid component of the milk

Mentions: Bovine milk is a complex biological fluid secreted by a dynamic and complex organ composed of various cell types working together for synthesis and secretion of milk as shown in Fig. 1. Milk is responsible with multifaceted functionality for the nourishment of young and provides a vital source of nutrition for humans of all ages. Bovine milk composition is dynamic in nature containing proteins and peptides, lipids, and complex carbohydrates with health benefits beyond the expected nutritional content. Its composition varies continuously due to different factors such as breed, feed, age, season and stage of lactation [11–13]. Although milk has evolved as a natural food under selective pressure to meet nutritional needs of different species, limited knowledge is available about changes in its components (e.g. proteins, lipids) in health and disease due to different environmental and physiological factors. Changes in the expression of these components alter normal functional properties of milk and would be expected to be indicative of systemic or local illness. However, much of the studies to date, have focused on the alteration of different milk components of exotic breeds (e.g. Jersey and Holstein–Friesian) [14, 15] with limited reports on Indian pure breed cows (e.g. Sahiwal, Tharparker) and buffaloes (e.g. Murrah, Jafarabadi), which are large contributors to Indian dairy industry.Fig. 1


Challenges and opportunities of bovine milk analysis by mass spectrometry.

Verma A, Ambatipudi K - Clin Proteomics (2016)

Schematic representation of the structure of mammary gland. a A general model of udder, b image of udder with complex tissue comprised of many ducts and alveoli, c an alveolus comprising of many cell types such as secretory and intercalating ducts, d an alveolus showing merocrine mode of secretion for protein component of the milk, e an alveolus showing apocrine mode of secretion for lipid component of the milk
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4836106&req=5

Fig1: Schematic representation of the structure of mammary gland. a A general model of udder, b image of udder with complex tissue comprised of many ducts and alveoli, c an alveolus comprising of many cell types such as secretory and intercalating ducts, d an alveolus showing merocrine mode of secretion for protein component of the milk, e an alveolus showing apocrine mode of secretion for lipid component of the milk
Mentions: Bovine milk is a complex biological fluid secreted by a dynamic and complex organ composed of various cell types working together for synthesis and secretion of milk as shown in Fig. 1. Milk is responsible with multifaceted functionality for the nourishment of young and provides a vital source of nutrition for humans of all ages. Bovine milk composition is dynamic in nature containing proteins and peptides, lipids, and complex carbohydrates with health benefits beyond the expected nutritional content. Its composition varies continuously due to different factors such as breed, feed, age, season and stage of lactation [11–13]. Although milk has evolved as a natural food under selective pressure to meet nutritional needs of different species, limited knowledge is available about changes in its components (e.g. proteins, lipids) in health and disease due to different environmental and physiological factors. Changes in the expression of these components alter normal functional properties of milk and would be expected to be indicative of systemic or local illness. However, much of the studies to date, have focused on the alteration of different milk components of exotic breeds (e.g. Jersey and Holstein–Friesian) [14, 15] with limited reports on Indian pure breed cows (e.g. Sahiwal, Tharparker) and buffaloes (e.g. Murrah, Jafarabadi), which are large contributors to Indian dairy industry.Fig. 1

Bottom Line: Although analyses of different milk components (e.g. proteins, lipids) pose huge challenges, the use of mass spectrometric (MS)-based techniques is steadily improving our understanding of the complexity of the biological traits that effect milk yield and its components to meet the global demand arising from population growth.In addition, different milk constituents have various applications in veterinary research and medicine, including early disease diagnosis.The aim of the review is to present an overview of the progress made in MS-based analysis of milk, and suggest a multi-pronged MS strategy to better explore different milk components for translational and clinical utilities.

View Article: PubMed Central - PubMed

Affiliation: Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667 India.

ABSTRACT
Bovine milk and its products (e.g. cheese, yoghurt) are an important part of human diet with beneficial effects for all ages. Although analyses of different milk components (e.g. proteins, lipids) pose huge challenges, the use of mass spectrometric (MS)-based techniques is steadily improving our understanding of the complexity of the biological traits that effect milk yield and its components to meet the global demand arising from population growth. In addition, different milk constituents have various applications in veterinary research and medicine, including early disease diagnosis. The aim of the review is to present an overview of the progress made in MS-based analysis of milk, and suggest a multi-pronged MS strategy to better explore different milk components for translational and clinical utilities.

No MeSH data available.