Limits...
Cross-border comparison of antibiotic prescriptions among children and adolescents between the north of the Netherlands and the north-west of Germany.

Dik JW, Sinha B, Friedrich AW, Lo-Ten-Foe JR, Hendrix R, Köck R, Bijker B, Postma MJ, Freitag MH, Glaeske G, Hoffmann F - Antimicrob Resist Infect Control (2016)

Bottom Line: The proportion of primary care patients receiving at least one antibiotic was lower in northern Netherlands (29.8 %; 95 % confidence interval [95 % CI]: 29.3-30.3), compared to north-west Germany (38.9 %; 95 % CI: 38.2-39.6).Most profound was the difference in second-generation cephalosporins: for German children 25 % of the total prescriptions, while for Dutch children it was less than 0.1 %.Considering increasing cross-border healthcare, these comparisons are highly valuable and help act upon antibiotic resistance in the first line of care in an international approach.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

ABSTRACT

Background: Antibiotic resistance is a worldwide problem and inappropriate prescriptions are a cause. Especially among children, prescriptions tend to be high. It is unclear how they differ in bordering regions. This study therefore examined the antibiotic prescription prevalence among children in primary care between northern Netherlands and north-west of Germany.

Methods: Two datasets were used: The Dutch (IADB) comprises representative data of pharmacists in North Netherland and the German (BARMER GEK) includes nationwide health insurance data. Both were filtered using postal codes to define two comparable bordering regions with patients under 18 years for 2010.

Results: The proportion of primary care patients receiving at least one antibiotic was lower in northern Netherlands (29.8 %; 95 % confidence interval [95 % CI]: 29.3-30.3), compared to north-west Germany (38.9 %; 95 % CI: 38.2-39.6). Within the respective countries, there were variations ranging from 27.0 to 44.1 % between different areas. Most profound was the difference in second-generation cephalosporins: for German children 25 % of the total prescriptions, while for Dutch children it was less than 0.1 %.

Conclusions: This study is the first to compare outpatient antibiotic prescriptions among children in primary care practices in bordering regions of two countries. Large differences were seen within and between the countries, with overall higher prescription prevalence in Germany. Considering increasing cross-border healthcare, these comparisons are highly valuable and help act upon antibiotic resistance in the first line of care in an international approach.

No MeSH data available.


Study regions in north of the Netherlands (postal codes 9xxx; n = 36,747) and north-west Germany (postal codes 26xxx; n = 18,374)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4836103&req=5

Fig1: Study regions in north of the Netherlands (postal codes 9xxx; n = 36,747) and north-west Germany (postal codes 26xxx; n = 18,374)

Mentions: To address the question, we chose a retrospective cross-sectional study in a predominantly rural region including analysis of outpatients’ data of a health insurance company and a pharmacy research database for north western Germany (postal codes 26xxx; part of Lower Saxony) and the northern Netherlands (postal codes 9xxx, Groningen/Drenthe). Both regions have no major geographic and infection risk differences, have about 1 million inhabitants and share a common green border (Fig. 1). Data comprises the year 2010 and we focused on persons aged 0 to 18 years. Orally administered antibiotics were selected based on the Anatomical Therapeutic Chemical (ATC) code J01 in the outpatient setting.Fig. 1


Cross-border comparison of antibiotic prescriptions among children and adolescents between the north of the Netherlands and the north-west of Germany.

Dik JW, Sinha B, Friedrich AW, Lo-Ten-Foe JR, Hendrix R, Köck R, Bijker B, Postma MJ, Freitag MH, Glaeske G, Hoffmann F - Antimicrob Resist Infect Control (2016)

Study regions in north of the Netherlands (postal codes 9xxx; n = 36,747) and north-west Germany (postal codes 26xxx; n = 18,374)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4836103&req=5

Fig1: Study regions in north of the Netherlands (postal codes 9xxx; n = 36,747) and north-west Germany (postal codes 26xxx; n = 18,374)
Mentions: To address the question, we chose a retrospective cross-sectional study in a predominantly rural region including analysis of outpatients’ data of a health insurance company and a pharmacy research database for north western Germany (postal codes 26xxx; part of Lower Saxony) and the northern Netherlands (postal codes 9xxx, Groningen/Drenthe). Both regions have no major geographic and infection risk differences, have about 1 million inhabitants and share a common green border (Fig. 1). Data comprises the year 2010 and we focused on persons aged 0 to 18 years. Orally administered antibiotics were selected based on the Anatomical Therapeutic Chemical (ATC) code J01 in the outpatient setting.Fig. 1

Bottom Line: The proportion of primary care patients receiving at least one antibiotic was lower in northern Netherlands (29.8 %; 95 % confidence interval [95 % CI]: 29.3-30.3), compared to north-west Germany (38.9 %; 95 % CI: 38.2-39.6).Most profound was the difference in second-generation cephalosporins: for German children 25 % of the total prescriptions, while for Dutch children it was less than 0.1 %.Considering increasing cross-border healthcare, these comparisons are highly valuable and help act upon antibiotic resistance in the first line of care in an international approach.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

ABSTRACT

Background: Antibiotic resistance is a worldwide problem and inappropriate prescriptions are a cause. Especially among children, prescriptions tend to be high. It is unclear how they differ in bordering regions. This study therefore examined the antibiotic prescription prevalence among children in primary care between northern Netherlands and north-west of Germany.

Methods: Two datasets were used: The Dutch (IADB) comprises representative data of pharmacists in North Netherland and the German (BARMER GEK) includes nationwide health insurance data. Both were filtered using postal codes to define two comparable bordering regions with patients under 18 years for 2010.

Results: The proportion of primary care patients receiving at least one antibiotic was lower in northern Netherlands (29.8 %; 95 % confidence interval [95 % CI]: 29.3-30.3), compared to north-west Germany (38.9 %; 95 % CI: 38.2-39.6). Within the respective countries, there were variations ranging from 27.0 to 44.1 % between different areas. Most profound was the difference in second-generation cephalosporins: for German children 25 % of the total prescriptions, while for Dutch children it was less than 0.1 %.

Conclusions: This study is the first to compare outpatient antibiotic prescriptions among children in primary care practices in bordering regions of two countries. Large differences were seen within and between the countries, with overall higher prescription prevalence in Germany. Considering increasing cross-border healthcare, these comparisons are highly valuable and help act upon antibiotic resistance in the first line of care in an international approach.

No MeSH data available.