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Glandular odontogenic cyst: A diagnostic dilemma.

Shah AA, Sangle A, Bussari S, Koshy AV - Indian J Dent (2016 Jan-Mar)

Bottom Line: It poses a diagnostic challenge as it can be clinically and histopathologically confused with lateral periodontal cyst, botryoid odontogenic cyst, radicular and residual cysts with mucous metaplasia, and low-grade mucoepidermoid carcinoma.The present case report describes GOC in both male and female patients with intra-oral swelling following extraction of 36 and 46, respectively.Careful histopathological examination is needed to diagnose GOC, and a careful long-term follow-up is advocated.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology and Microbiology, M.A. Rangoonwala College of Dental Sciences and Research Centre, Azam Campus, Pune, Maharashtra, India.

ABSTRACT
Glandular odontogenic cyst (GOC) is a rare and uncommon jaw bone cyst of odontogenic origin described in 1987 by Gardener et al. as a distinct entity. It is a cyst having an unpredictable, potentially aggressive behavior, and has the propensity to grow in large size with relatively high recurrence rate. It poses a diagnostic challenge as it can be clinically and histopathologically confused with lateral periodontal cyst, botryoid odontogenic cyst, radicular and residual cysts with mucous metaplasia, and low-grade mucoepidermoid carcinoma. The present case report describes GOC in both male and female patients with intra-oral swelling following extraction of 36 and 46, respectively. Careful histopathological examination is needed to diagnose GOC, and a careful long-term follow-up is advocated.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph demonstrating nonkeratinising cystic epithelial lining and supporting connective tissue capsule with flat interphase (H and E, ×4)
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Figure 7: Photomicrograph demonstrating nonkeratinising cystic epithelial lining and supporting connective tissue capsule with flat interphase (H and E, ×4)

Mentions: Histopathological examination for both the cases revealed the presence of cystic lumen with epithelial lining and supporting connective tissue capsule. The epithelial lining was 2–3 cell layers thick with a flat epithelio-mesenchymal interface, and at places showed variable thickness with luminal proliferation. The epithelial lining showed few surface cuboidal eosinophilic cells (Hob-nail cells) and few goblet cells. Juxta-epithelial area revealed the hyalinized area suggestive of dentinoid. The connective tissue capsule showed parallelly arranged collagen fibers, few foreign body giant cells, and few blood vessels. Based on these findings, histopathologically it was diagnosed as GOC [Figures 7–10].


Glandular odontogenic cyst: A diagnostic dilemma.

Shah AA, Sangle A, Bussari S, Koshy AV - Indian J Dent (2016 Jan-Mar)

Photomicrograph demonstrating nonkeratinising cystic epithelial lining and supporting connective tissue capsule with flat interphase (H and E, ×4)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836096&req=5

Figure 7: Photomicrograph demonstrating nonkeratinising cystic epithelial lining and supporting connective tissue capsule with flat interphase (H and E, ×4)
Mentions: Histopathological examination for both the cases revealed the presence of cystic lumen with epithelial lining and supporting connective tissue capsule. The epithelial lining was 2–3 cell layers thick with a flat epithelio-mesenchymal interface, and at places showed variable thickness with luminal proliferation. The epithelial lining showed few surface cuboidal eosinophilic cells (Hob-nail cells) and few goblet cells. Juxta-epithelial area revealed the hyalinized area suggestive of dentinoid. The connective tissue capsule showed parallelly arranged collagen fibers, few foreign body giant cells, and few blood vessels. Based on these findings, histopathologically it was diagnosed as GOC [Figures 7–10].

Bottom Line: It poses a diagnostic challenge as it can be clinically and histopathologically confused with lateral periodontal cyst, botryoid odontogenic cyst, radicular and residual cysts with mucous metaplasia, and low-grade mucoepidermoid carcinoma.The present case report describes GOC in both male and female patients with intra-oral swelling following extraction of 36 and 46, respectively.Careful histopathological examination is needed to diagnose GOC, and a careful long-term follow-up is advocated.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology and Microbiology, M.A. Rangoonwala College of Dental Sciences and Research Centre, Azam Campus, Pune, Maharashtra, India.

ABSTRACT
Glandular odontogenic cyst (GOC) is a rare and uncommon jaw bone cyst of odontogenic origin described in 1987 by Gardener et al. as a distinct entity. It is a cyst having an unpredictable, potentially aggressive behavior, and has the propensity to grow in large size with relatively high recurrence rate. It poses a diagnostic challenge as it can be clinically and histopathologically confused with lateral periodontal cyst, botryoid odontogenic cyst, radicular and residual cysts with mucous metaplasia, and low-grade mucoepidermoid carcinoma. The present case report describes GOC in both male and female patients with intra-oral swelling following extraction of 36 and 46, respectively. Careful histopathological examination is needed to diagnose GOC, and a careful long-term follow-up is advocated.

No MeSH data available.


Related in: MedlinePlus