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Evaluation of bone morphogenic proteins in periodontal practice.

Kaur S, Grover V, Kaur H, Malhotra R - Indian J Dent (2016 Jan-Mar)

Bottom Line: The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus.Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject.On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

ABSTRACT
Forty years ago Marshal R. Urist discovered a substance in bone matrix that had inductive properties for the development of bone and cartilage, until date, at least 20 bone morphogenetic proteins (BMPs) have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. The purpose of this paper is to give a brief overview of BMPs and to review critically the clinical data currently available on the use of BMPs in various periodontal applications. The literature on BMPs was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal applications were included. The available literature was analyzed and compiled. The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

No MeSH data available.


Related in: MedlinePlus

Three-dimensional CT scan of size defect (a) and CAD plan of ideal mandibular transplant (b). Titanium cage filled with bone mineral block infiltrated with recombinant human BMP7 and bone-marrow mixture (c). Dorsal view of mandibular replacement 3 weeks after implantation (d). Skeletal scintigraphy of implant (e). Three-dimensional CT scan after transplantation of the bone replacement with enhancement of soft tissue (f) and repeat skeletal (g) scintigraphy with tracer enhancement showing continued bone remodelling and mineralisation (arrows)
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Figure 6: Three-dimensional CT scan of size defect (a) and CAD plan of ideal mandibular transplant (b). Titanium cage filled with bone mineral block infiltrated with recombinant human BMP7 and bone-marrow mixture (c). Dorsal view of mandibular replacement 3 weeks after implantation (d). Skeletal scintigraphy of implant (e). Three-dimensional CT scan after transplantation of the bone replacement with enhancement of soft tissue (f) and repeat skeletal (g) scintigraphy with tracer enhancement showing continued bone remodelling and mineralisation (arrows)

Mentions: BMPs have been used in craniofacial reconstruction including chronic and acute posttraumatic discontinuity defects, congenital malformations (Apert and Crouzon syndromes), and large (tumor) resection defects[105107] [Figure 6]. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in craniofacial reconstruction.


Evaluation of bone morphogenic proteins in periodontal practice.

Kaur S, Grover V, Kaur H, Malhotra R - Indian J Dent (2016 Jan-Mar)

Three-dimensional CT scan of size defect (a) and CAD plan of ideal mandibular transplant (b). Titanium cage filled with bone mineral block infiltrated with recombinant human BMP7 and bone-marrow mixture (c). Dorsal view of mandibular replacement 3 weeks after implantation (d). Skeletal scintigraphy of implant (e). Three-dimensional CT scan after transplantation of the bone replacement with enhancement of soft tissue (f) and repeat skeletal (g) scintigraphy with tracer enhancement showing continued bone remodelling and mineralisation (arrows)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836095&req=5

Figure 6: Three-dimensional CT scan of size defect (a) and CAD plan of ideal mandibular transplant (b). Titanium cage filled with bone mineral block infiltrated with recombinant human BMP7 and bone-marrow mixture (c). Dorsal view of mandibular replacement 3 weeks after implantation (d). Skeletal scintigraphy of implant (e). Three-dimensional CT scan after transplantation of the bone replacement with enhancement of soft tissue (f) and repeat skeletal (g) scintigraphy with tracer enhancement showing continued bone remodelling and mineralisation (arrows)
Mentions: BMPs have been used in craniofacial reconstruction including chronic and acute posttraumatic discontinuity defects, congenital malformations (Apert and Crouzon syndromes), and large (tumor) resection defects[105107] [Figure 6]. Clinical studies optimizing dose, delivery technologies, and conditions for stimulation of bone growth will bring about a new era in craniofacial reconstruction.

Bottom Line: The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus.Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject.On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

ABSTRACT
Forty years ago Marshal R. Urist discovered a substance in bone matrix that had inductive properties for the development of bone and cartilage, until date, at least 20 bone morphogenetic proteins (BMPs) have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. The purpose of this paper is to give a brief overview of BMPs and to review critically the clinical data currently available on the use of BMPs in various periodontal applications. The literature on BMPs was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal applications were included. The available literature was analyzed and compiled. The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

No MeSH data available.


Related in: MedlinePlus