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Evaluation of bone morphogenic proteins in periodontal practice.

Kaur S, Grover V, Kaur H, Malhotra R - Indian J Dent (2016 Jan-Mar)

Bottom Line: The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus.Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject.On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

ABSTRACT
Forty years ago Marshal R. Urist discovered a substance in bone matrix that had inductive properties for the development of bone and cartilage, until date, at least 20 bone morphogenetic proteins (BMPs) have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. The purpose of this paper is to give a brief overview of BMPs and to review critically the clinical data currently available on the use of BMPs in various periodontal applications. The literature on BMPs was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal applications were included. The available literature was analyzed and compiled. The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

No MeSH data available.


Mechanism of action of bone morphogenetic proteins
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Figure 3: Mechanism of action of bone morphogenetic proteins

Mentions: Type II BMP receptors are constitutively active kinases that transphosphorylate Type I receptors on ligand binding.[5] Although both Type I and Type II receptors can bind BMP ligand, their affinity for BMP is relatively low unless both receptors are present. Optimal binding of BMP occurs in the presence of both Type I and II BMP receptors. Once both Type I and II BMP receptors have bound BMP, Type II receptors transphosphorylate Type I. The phosphorylated Type I receptor in turn phosphorylates several intracellular messengers: Smads 1, 5, and 8. The pattern of Smad activation depends on which Type I BMP receptor is activated. The intracellular Smads 1 and 5 are activated by BMP-Ia and BMP-Ib receptors, whereas Smads 1, 5, and 8 are activated by activing receptor-like kinase-2 receptors.[6] After phosphylation, the receptor Smads form heteromeric complexes with Smad-4, a co-Smad, prior to translocation into the cell nucleus.[57] Once within the nucleus, transcription is activated; the pattern of transcription depends on the cell line and the ligand used. In mesenchymal bone marrow stem cells, increased gene expression of Type I collagen, osteopontin, and osteocalcin results from exposure to BMP-2.[89] Through receptor stimulation and selective gene expression, rhBMP-2 induces osteoinduction by first recruiting mesenchymal stem cells and then inducing the proliferation and differentiation of these cells into an osteoprogenitor lineage.[10] After incubation with rhBMP-2, mesenchymal bone marrow cells have increased alkaline phosphatase activity and are able to undergo matrix mineralization in vitro,[111213141516] [Figure 3].


Evaluation of bone morphogenic proteins in periodontal practice.

Kaur S, Grover V, Kaur H, Malhotra R - Indian J Dent (2016 Jan-Mar)

Mechanism of action of bone morphogenetic proteins
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836095&req=5

Figure 3: Mechanism of action of bone morphogenetic proteins
Mentions: Type II BMP receptors are constitutively active kinases that transphosphorylate Type I receptors on ligand binding.[5] Although both Type I and Type II receptors can bind BMP ligand, their affinity for BMP is relatively low unless both receptors are present. Optimal binding of BMP occurs in the presence of both Type I and II BMP receptors. Once both Type I and II BMP receptors have bound BMP, Type II receptors transphosphorylate Type I. The phosphorylated Type I receptor in turn phosphorylates several intracellular messengers: Smads 1, 5, and 8. The pattern of Smad activation depends on which Type I BMP receptor is activated. The intracellular Smads 1 and 5 are activated by BMP-Ia and BMP-Ib receptors, whereas Smads 1, 5, and 8 are activated by activing receptor-like kinase-2 receptors.[6] After phosphylation, the receptor Smads form heteromeric complexes with Smad-4, a co-Smad, prior to translocation into the cell nucleus.[57] Once within the nucleus, transcription is activated; the pattern of transcription depends on the cell line and the ligand used. In mesenchymal bone marrow stem cells, increased gene expression of Type I collagen, osteopontin, and osteocalcin results from exposure to BMP-2.[89] Through receptor stimulation and selective gene expression, rhBMP-2 induces osteoinduction by first recruiting mesenchymal stem cells and then inducing the proliferation and differentiation of these cells into an osteoprogenitor lineage.[10] After incubation with rhBMP-2, mesenchymal bone marrow cells have increased alkaline phosphatase activity and are able to undergo matrix mineralization in vitro,[111213141516] [Figure 3].

Bottom Line: The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus.Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject.On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

ABSTRACT
Forty years ago Marshal R. Urist discovered a substance in bone matrix that had inductive properties for the development of bone and cartilage, until date, at least 20 bone morphogenetic proteins (BMPs) have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. The purpose of this paper is to give a brief overview of BMPs and to review critically the clinical data currently available on the use of BMPs in various periodontal applications. The literature on BMPs was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal applications were included. The available literature was analyzed and compiled. The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

No MeSH data available.