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Evaluation of bone morphogenic proteins in periodontal practice.

Kaur S, Grover V, Kaur H, Malhotra R - Indian J Dent (2016 Jan-Mar)

Bottom Line: The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus.Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject.On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

ABSTRACT
Forty years ago Marshal R. Urist discovered a substance in bone matrix that had inductive properties for the development of bone and cartilage, until date, at least 20 bone morphogenetic proteins (BMPs) have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. The purpose of this paper is to give a brief overview of BMPs and to review critically the clinical data currently available on the use of BMPs in various periodontal applications. The literature on BMPs was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal applications were included. The available literature was analyzed and compiled. The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

No MeSH data available.


Precursor form of bone morphogenetic proteins
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Figure 1: Precursor form of bone morphogenetic proteins

Mentions: BMPs are members of TGF-β super family, a large family of growth factors.[1] BMPs are synthesized inside the cell in a precursor form with a hydrophobic secretory leader, and pro-peptide sequences joined to the mature region [Figure 1]. After demineralization, these proteins are cleaved proteolytically at a consensus Arg-X-X-Arg site to generate mature dimers. It has been shown that the N-terminal region controls the stability of the processed mature protein and that the downstream sequence adjacent to the cleavage site determines the efficiency of cleavage.[2] BMPs are distinguished from other members of the family by having, in general, seven, rather than nine, conserved cysteines in the mature region.[34] BMPs consist of dimers whose chains are connected by disulfide bonds, and this dimerization is a prerequisite for bone induction. BMPs are active both as homodimer (two identical chains) and heterodimer (two different chains) molecules. The monomer presents three disulfide bonds, the cysteine knot (McDonald and Hendrickson 1993) constituting the monomer core, and four strands of antiparallel ß-sheet, which emanate from the knot forming two finger-like projections[4] [Figure 2].


Evaluation of bone morphogenic proteins in periodontal practice.

Kaur S, Grover V, Kaur H, Malhotra R - Indian J Dent (2016 Jan-Mar)

Precursor form of bone morphogenetic proteins
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836095&req=5

Figure 1: Precursor form of bone morphogenetic proteins
Mentions: BMPs are members of TGF-β super family, a large family of growth factors.[1] BMPs are synthesized inside the cell in a precursor form with a hydrophobic secretory leader, and pro-peptide sequences joined to the mature region [Figure 1]. After demineralization, these proteins are cleaved proteolytically at a consensus Arg-X-X-Arg site to generate mature dimers. It has been shown that the N-terminal region controls the stability of the processed mature protein and that the downstream sequence adjacent to the cleavage site determines the efficiency of cleavage.[2] BMPs are distinguished from other members of the family by having, in general, seven, rather than nine, conserved cysteines in the mature region.[34] BMPs consist of dimers whose chains are connected by disulfide bonds, and this dimerization is a prerequisite for bone induction. BMPs are active both as homodimer (two identical chains) and heterodimer (two different chains) molecules. The monomer presents three disulfide bonds, the cysteine knot (McDonald and Hendrickson 1993) constituting the monomer core, and four strands of antiparallel ß-sheet, which emanate from the knot forming two finger-like projections[4] [Figure 2].

Bottom Line: The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus.Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject.On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontics, Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar, Punjab, India.

ABSTRACT
Forty years ago Marshal R. Urist discovered a substance in bone matrix that had inductive properties for the development of bone and cartilage, until date, at least 20 bone morphogenetic proteins (BMPs) have been identified, some of which have been shown in vitro to stimulate the process of stem cell differentiation into osteoblasts in human and animal models. The purpose of this paper is to give a brief overview of BMPs and to review critically the clinical data currently available on the use of BMPs in various periodontal applications. The literature on BMPs was reviewed. A comprehensive search was designed. The articles were independently screened for eligibility. Articles with authentic controls and proper randomization and pertaining specifically to their role in periodontal applications were included. The available literature was analyzed and compiled. The analysis indicates BMPs to be a promising, as well as an effective novel approach to reconstruct and engineer the periodontal apparatus. Here, we represent several articles, as well as recent texts that make up a special and an in-depth review on the subject. On the basis of the data provided in the studies that were reviewed BMPs provide revolutionary therapies in periodontal practice.

No MeSH data available.