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To estimate the efficacy of 0.1% tacrolimus with Colgate Oraguard-B paste for the treatment of patients with symptomatic oral lichen planus.

Nisa SU, Saggu TK - Indian J Dent (2016 Jan-Mar)

Bottom Line: Sixty-five (43.33%) patients had marked resolution of their lesions, i.e., the size of the lesion was decreased.Fourteen (9.33%) patients had remission of lesion (reduction in burning sensation and size of lesion) in symptoms as recorded by the VAS.Topical tacrolimus ointment 0.1% in Oraguard-B paste is an effective treatment for different types of OLP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India.

ABSTRACT

Aim and objectives: To investigate the efficacy of 0.1% tacrolimus with Colgate Oraguard-B paste for the treatment of patients with oral lichen planus (OLP).

Materials and methods: One hundred and fifty patients with symptomatic OLP participated in the study, who had clinically and histopathologically proven OLP. In this study, patients were provided with 0.1% tacrolimus ointment with Colgate Oraguard-B paste as the study medication. Patients were asked to use the medication over the areas three times a day until resolution of the lesion. Patients were recalled to assess the drug response every 15 days. The duration of treatment ranged from 3 months to 4 months, with follow-up of 2 years and 6 months.

Statistical analysis: The Wilcoxon signed-rank test was performed, which is a nonparametric statistical hypothesis test for comparing two related samples, matched samples or repeated measurements on a single sample to assess whether their population mean ranks differ (i.e., it is a paired difference test). In our study, the pre- and post-Visual Analogue Scale (VAS) values were compared and the mean, standard deviation and P values were calculated.

Results: Of 150 patients, 71 (47.33%) patients had complete resolution of the lesion to the topical tacrolimus therapy. Sixty-five (43.33%) patients had marked resolution of their lesions, i.e., the size of the lesion was decreased. Fourteen (9.33%) patients had remission of lesion (reduction in burning sensation and size of lesion) in symptoms as recorded by the VAS.

Conclusion: Topical tacrolimus ointment 0.1% in Oraguard-B paste is an effective treatment for different types of OLP.

No MeSH data available.


Related in: MedlinePlus

Different types of lichen planus (pre- and posttreatment). (1a) Atrophic lichen planus (pre-operative), (1b) atrophic lichen planus (post-operative), (2a) mixed lichen planus (pre-operative), (2b) mixed lichen planus (post-operative), (3a) erosive lichen planus (pre-operative), (3b) erosive lichen planus (post-operative) (4a) reticular lichen planus (pre-operative), (4b) reticular lichen planus (post-operative)
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Figure 3: Different types of lichen planus (pre- and posttreatment). (1a) Atrophic lichen planus (pre-operative), (1b) atrophic lichen planus (post-operative), (2a) mixed lichen planus (pre-operative), (2b) mixed lichen planus (post-operative), (3a) erosive lichen planus (pre-operative), (3b) erosive lichen planus (post-operative) (4a) reticular lichen planus (pre-operative), (4b) reticular lichen planus (post-operative)

Mentions: The clinical response of 150 patients with different types of OLP was recorded following topical application of tacrolimus therapy for 2 years and 6 months. In 150 patients, 71 (47.33%) patients had complete remission or complete reduction in size of lesion after tacrolimus therapy for the duration of 13–25 months. Sixty-five (43.33%) patients had partial remission of lesion after tacrolimus therapy for the duration of 15–28 months [Figure 2]. Fourteen (9.33%) patients had no response or recurrence after tacrolimus therapy for a duration of 4–6 months.


To estimate the efficacy of 0.1% tacrolimus with Colgate Oraguard-B paste for the treatment of patients with symptomatic oral lichen planus.

Nisa SU, Saggu TK - Indian J Dent (2016 Jan-Mar)

Different types of lichen planus (pre- and posttreatment). (1a) Atrophic lichen planus (pre-operative), (1b) atrophic lichen planus (post-operative), (2a) mixed lichen planus (pre-operative), (2b) mixed lichen planus (post-operative), (3a) erosive lichen planus (pre-operative), (3b) erosive lichen planus (post-operative) (4a) reticular lichen planus (pre-operative), (4b) reticular lichen planus (post-operative)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836094&req=5

Figure 3: Different types of lichen planus (pre- and posttreatment). (1a) Atrophic lichen planus (pre-operative), (1b) atrophic lichen planus (post-operative), (2a) mixed lichen planus (pre-operative), (2b) mixed lichen planus (post-operative), (3a) erosive lichen planus (pre-operative), (3b) erosive lichen planus (post-operative) (4a) reticular lichen planus (pre-operative), (4b) reticular lichen planus (post-operative)
Mentions: The clinical response of 150 patients with different types of OLP was recorded following topical application of tacrolimus therapy for 2 years and 6 months. In 150 patients, 71 (47.33%) patients had complete remission or complete reduction in size of lesion after tacrolimus therapy for the duration of 13–25 months. Sixty-five (43.33%) patients had partial remission of lesion after tacrolimus therapy for the duration of 15–28 months [Figure 2]. Fourteen (9.33%) patients had no response or recurrence after tacrolimus therapy for a duration of 4–6 months.

Bottom Line: Sixty-five (43.33%) patients had marked resolution of their lesions, i.e., the size of the lesion was decreased.Fourteen (9.33%) patients had remission of lesion (reduction in burning sensation and size of lesion) in symptoms as recorded by the VAS.Topical tacrolimus ointment 0.1% in Oraguard-B paste is an effective treatment for different types of OLP.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India.

ABSTRACT

Aim and objectives: To investigate the efficacy of 0.1% tacrolimus with Colgate Oraguard-B paste for the treatment of patients with oral lichen planus (OLP).

Materials and methods: One hundred and fifty patients with symptomatic OLP participated in the study, who had clinically and histopathologically proven OLP. In this study, patients were provided with 0.1% tacrolimus ointment with Colgate Oraguard-B paste as the study medication. Patients were asked to use the medication over the areas three times a day until resolution of the lesion. Patients were recalled to assess the drug response every 15 days. The duration of treatment ranged from 3 months to 4 months, with follow-up of 2 years and 6 months.

Statistical analysis: The Wilcoxon signed-rank test was performed, which is a nonparametric statistical hypothesis test for comparing two related samples, matched samples or repeated measurements on a single sample to assess whether their population mean ranks differ (i.e., it is a paired difference test). In our study, the pre- and post-Visual Analogue Scale (VAS) values were compared and the mean, standard deviation and P values were calculated.

Results: Of 150 patients, 71 (47.33%) patients had complete resolution of the lesion to the topical tacrolimus therapy. Sixty-five (43.33%) patients had marked resolution of their lesions, i.e., the size of the lesion was decreased. Fourteen (9.33%) patients had remission of lesion (reduction in burning sensation and size of lesion) in symptoms as recorded by the VAS.

Conclusion: Topical tacrolimus ointment 0.1% in Oraguard-B paste is an effective treatment for different types of OLP.

No MeSH data available.


Related in: MedlinePlus