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A comparative evaluation of the effect of diclofenac sodium with and without per-orally administered methylprednisolone on the sequelae of impacted mandibular third molar removal: A cohort randomized double-blind clinical trial.

Prashar DV, Pahwa D, Kalia V, Jindal G, Kaur R - Indian J Dent (2016 Jan-Mar)

Bottom Line: Mean difference in pain experienced between the two groups was statistically significant at 24 h (P = 0.015) and 72 h (P = 0.001) and on the seventh day (P = 0.005).Difference in inter-incisal distance was insignificant (P = 0.239) pre-operatively, but significant after 24 h (P = 0.014) and 72 h (P = 0.001) and on the seventh post-operative day (P = 0.001).The combination of oral dose of methylprednisolone (a corticosteroid) diclofenac sodium (a non-steroidal anti-inflammatory drug) was found to be more effective than diclofenac sodium alone on the sequelae of surgical removal of impacted mandibular third molar.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, Swami Devi Dayal Hospital and Dental College, Panchkula, Haryana, India.

ABSTRACT

Aim and objectives: This study evaluated the efficacy of oral methylprednisolone and diclofenac sodium on post-operative sequelae after third molar surgery.

Settings and design: A randomized double-blind clinical trial was conducted (with institutional and university approval for dissertation) to evaluate the effect of methylprednisolone with diclofenac sodium (group A) as compared with diclofenac sodium and placebo (group B) on three variables: Pain, swelling and trismus, after third molar surgery.

Materials and methods: Thirty consecutive consenting patients for surgical removal of mandibular impacted third molar were randomly placed into two groups of 15 each (groups A and B). Pain, swelling and trismus were observed by visual analog scale, facial measurements and inter-incisal opening. Scores were recorded after 24 and 72 h and on the seventh post-operative day. Results were subjected to the Chi-square test and independent sample t-test (P = 0.05).

Results: Mean difference in pain experienced between the two groups was statistically significant at 24 h (P = 0.015) and 72 h (P = 0.001) and on the seventh day (P = 0.005). Difference in inter-incisal distance was insignificant (P = 0.239) pre-operatively, but significant after 24 h (P = 0.014) and 72 h (P = 0.001) and on the seventh post-operative day (P = 0.001). Mean difference in swelling was highly significant after 24 h (P = 0.001) and 72 h (P = 0.0001) and on the seventh post-operative day (P = 0.047).

Conclusions: The combination of oral dose of methylprednisolone (a corticosteroid) diclofenac sodium (a non-steroidal anti-inflammatory drug) was found to be more effective than diclofenac sodium alone on the sequelae of surgical removal of impacted mandibular third molar.

No MeSH data available.


Related in: MedlinePlus

Comparing the mean facial measurement between group A and group B
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Figure 5: Comparing the mean facial measurement between group A and group B

Mentions: In group A [Graph 3], mean FM measured pre-operatively was 379.6±23.36 mm, 391.2±24.119 mm after 24 h, 382.86±23.18) mm after 72 h and 380.2±23.32 on the seventh post-operative day. In group B, the mean FM measured pre-operatively was 355.4±24.49 mm, 383.3±25.93 mm after 24 h, 371.53±23.76 mm after 72 h and 357.73±24.38 mm on the seventh post-operative day. The mean difference in change in FM between the two groups after applying the independent sample t-test was statistically highly significant after 24 h (P = 0.001) and 72 h (P = 0.0001), and still significant on the seventh post-operative day (P = 0.047).


A comparative evaluation of the effect of diclofenac sodium with and without per-orally administered methylprednisolone on the sequelae of impacted mandibular third molar removal: A cohort randomized double-blind clinical trial.

Prashar DV, Pahwa D, Kalia V, Jindal G, Kaur R - Indian J Dent (2016 Jan-Mar)

Comparing the mean facial measurement between group A and group B
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836092&req=5

Figure 5: Comparing the mean facial measurement between group A and group B
Mentions: In group A [Graph 3], mean FM measured pre-operatively was 379.6±23.36 mm, 391.2±24.119 mm after 24 h, 382.86±23.18) mm after 72 h and 380.2±23.32 on the seventh post-operative day. In group B, the mean FM measured pre-operatively was 355.4±24.49 mm, 383.3±25.93 mm after 24 h, 371.53±23.76 mm after 72 h and 357.73±24.38 mm on the seventh post-operative day. The mean difference in change in FM between the two groups after applying the independent sample t-test was statistically highly significant after 24 h (P = 0.001) and 72 h (P = 0.0001), and still significant on the seventh post-operative day (P = 0.047).

Bottom Line: Mean difference in pain experienced between the two groups was statistically significant at 24 h (P = 0.015) and 72 h (P = 0.001) and on the seventh day (P = 0.005).Difference in inter-incisal distance was insignificant (P = 0.239) pre-operatively, but significant after 24 h (P = 0.014) and 72 h (P = 0.001) and on the seventh post-operative day (P = 0.001).The combination of oral dose of methylprednisolone (a corticosteroid) diclofenac sodium (a non-steroidal anti-inflammatory drug) was found to be more effective than diclofenac sodium alone on the sequelae of surgical removal of impacted mandibular third molar.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, Swami Devi Dayal Hospital and Dental College, Panchkula, Haryana, India.

ABSTRACT

Aim and objectives: This study evaluated the efficacy of oral methylprednisolone and diclofenac sodium on post-operative sequelae after third molar surgery.

Settings and design: A randomized double-blind clinical trial was conducted (with institutional and university approval for dissertation) to evaluate the effect of methylprednisolone with diclofenac sodium (group A) as compared with diclofenac sodium and placebo (group B) on three variables: Pain, swelling and trismus, after third molar surgery.

Materials and methods: Thirty consecutive consenting patients for surgical removal of mandibular impacted third molar were randomly placed into two groups of 15 each (groups A and B). Pain, swelling and trismus were observed by visual analog scale, facial measurements and inter-incisal opening. Scores were recorded after 24 and 72 h and on the seventh post-operative day. Results were subjected to the Chi-square test and independent sample t-test (P = 0.05).

Results: Mean difference in pain experienced between the two groups was statistically significant at 24 h (P = 0.015) and 72 h (P = 0.001) and on the seventh day (P = 0.005). Difference in inter-incisal distance was insignificant (P = 0.239) pre-operatively, but significant after 24 h (P = 0.014) and 72 h (P = 0.001) and on the seventh post-operative day (P = 0.001). Mean difference in swelling was highly significant after 24 h (P = 0.001) and 72 h (P = 0.0001) and on the seventh post-operative day (P = 0.047).

Conclusions: The combination of oral dose of methylprednisolone (a corticosteroid) diclofenac sodium (a non-steroidal anti-inflammatory drug) was found to be more effective than diclofenac sodium alone on the sequelae of surgical removal of impacted mandibular third molar.

No MeSH data available.


Related in: MedlinePlus