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A comparative evaluation of the effect of diclofenac sodium with and without per-orally administered methylprednisolone on the sequelae of impacted mandibular third molar removal: A cohort randomized double-blind clinical trial.

Prashar DV, Pahwa D, Kalia V, Jindal G, Kaur R - Indian J Dent (2016 Jan-Mar)

Bottom Line: Mean difference in pain experienced between the two groups was statistically significant at 24 h (P = 0.015) and 72 h (P = 0.001) and on the seventh day (P = 0.005).Difference in inter-incisal distance was insignificant (P = 0.239) pre-operatively, but significant after 24 h (P = 0.014) and 72 h (P = 0.001) and on the seventh post-operative day (P = 0.001).The combination of oral dose of methylprednisolone (a corticosteroid) diclofenac sodium (a non-steroidal anti-inflammatory drug) was found to be more effective than diclofenac sodium alone on the sequelae of surgical removal of impacted mandibular third molar.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, Swami Devi Dayal Hospital and Dental College, Panchkula, Haryana, India.

ABSTRACT

Aim and objectives: This study evaluated the efficacy of oral methylprednisolone and diclofenac sodium on post-operative sequelae after third molar surgery.

Settings and design: A randomized double-blind clinical trial was conducted (with institutional and university approval for dissertation) to evaluate the effect of methylprednisolone with diclofenac sodium (group A) as compared with diclofenac sodium and placebo (group B) on three variables: Pain, swelling and trismus, after third molar surgery.

Materials and methods: Thirty consecutive consenting patients for surgical removal of mandibular impacted third molar were randomly placed into two groups of 15 each (groups A and B). Pain, swelling and trismus were observed by visual analog scale, facial measurements and inter-incisal opening. Scores were recorded after 24 and 72 h and on the seventh post-operative day. Results were subjected to the Chi-square test and independent sample t-test (P = 0.05).

Results: Mean difference in pain experienced between the two groups was statistically significant at 24 h (P = 0.015) and 72 h (P = 0.001) and on the seventh day (P = 0.005). Difference in inter-incisal distance was insignificant (P = 0.239) pre-operatively, but significant after 24 h (P = 0.014) and 72 h (P = 0.001) and on the seventh post-operative day (P = 0.001). Mean difference in swelling was highly significant after 24 h (P = 0.001) and 72 h (P = 0.0001) and on the seventh post-operative day (P = 0.047).

Conclusions: The combination of oral dose of methylprednisolone (a corticosteroid) diclofenac sodium (a non-steroidal anti-inflammatory drug) was found to be more effective than diclofenac sodium alone on the sequelae of surgical removal of impacted mandibular third molar.

No MeSH data available.


Related in: MedlinePlus

Measuring maximal distance between the right maxillary and the mandibular incisor with a vernier caliper
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Figure 2: Measuring maximal distance between the right maxillary and the mandibular incisor with a vernier caliper

Mentions: The details recorded pre-operatively included the tooth to be removed, type of impaction, inter-incisal distance (IID) and facial baseline measurement (FM). FM was determined by a modification of the tape measuring method described by Gabka and Matsumara.[11] Three measurements were made between five reference points: Mandibular angle (G), tragus (T), lateral canthus of the eye (L), outer corner of the mouth (A) and soft tissue pogonion (P) by using a measuring tape to follow the contour of the face [Figure 1]. The sum of all measurements (FM1 + FM2 + FM3) was taken as the facial size (FM). IID was evaluated by measuring the distance on maximal opening between the right maxillary and mandibular incisor with a vernier caliper [Figure 2].[11]


A comparative evaluation of the effect of diclofenac sodium with and without per-orally administered methylprednisolone on the sequelae of impacted mandibular third molar removal: A cohort randomized double-blind clinical trial.

Prashar DV, Pahwa D, Kalia V, Jindal G, Kaur R - Indian J Dent (2016 Jan-Mar)

Measuring maximal distance between the right maxillary and the mandibular incisor with a vernier caliper
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4836092&req=5

Figure 2: Measuring maximal distance between the right maxillary and the mandibular incisor with a vernier caliper
Mentions: The details recorded pre-operatively included the tooth to be removed, type of impaction, inter-incisal distance (IID) and facial baseline measurement (FM). FM was determined by a modification of the tape measuring method described by Gabka and Matsumara.[11] Three measurements were made between five reference points: Mandibular angle (G), tragus (T), lateral canthus of the eye (L), outer corner of the mouth (A) and soft tissue pogonion (P) by using a measuring tape to follow the contour of the face [Figure 1]. The sum of all measurements (FM1 + FM2 + FM3) was taken as the facial size (FM). IID was evaluated by measuring the distance on maximal opening between the right maxillary and mandibular incisor with a vernier caliper [Figure 2].[11]

Bottom Line: Mean difference in pain experienced between the two groups was statistically significant at 24 h (P = 0.015) and 72 h (P = 0.001) and on the seventh day (P = 0.005).Difference in inter-incisal distance was insignificant (P = 0.239) pre-operatively, but significant after 24 h (P = 0.014) and 72 h (P = 0.001) and on the seventh post-operative day (P = 0.001).The combination of oral dose of methylprednisolone (a corticosteroid) diclofenac sodium (a non-steroidal anti-inflammatory drug) was found to be more effective than diclofenac sodium alone on the sequelae of surgical removal of impacted mandibular third molar.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, Swami Devi Dayal Hospital and Dental College, Panchkula, Haryana, India.

ABSTRACT

Aim and objectives: This study evaluated the efficacy of oral methylprednisolone and diclofenac sodium on post-operative sequelae after third molar surgery.

Settings and design: A randomized double-blind clinical trial was conducted (with institutional and university approval for dissertation) to evaluate the effect of methylprednisolone with diclofenac sodium (group A) as compared with diclofenac sodium and placebo (group B) on three variables: Pain, swelling and trismus, after third molar surgery.

Materials and methods: Thirty consecutive consenting patients for surgical removal of mandibular impacted third molar were randomly placed into two groups of 15 each (groups A and B). Pain, swelling and trismus were observed by visual analog scale, facial measurements and inter-incisal opening. Scores were recorded after 24 and 72 h and on the seventh post-operative day. Results were subjected to the Chi-square test and independent sample t-test (P = 0.05).

Results: Mean difference in pain experienced between the two groups was statistically significant at 24 h (P = 0.015) and 72 h (P = 0.001) and on the seventh day (P = 0.005). Difference in inter-incisal distance was insignificant (P = 0.239) pre-operatively, but significant after 24 h (P = 0.014) and 72 h (P = 0.001) and on the seventh post-operative day (P = 0.001). Mean difference in swelling was highly significant after 24 h (P = 0.001) and 72 h (P = 0.0001) and on the seventh post-operative day (P = 0.047).

Conclusions: The combination of oral dose of methylprednisolone (a corticosteroid) diclofenac sodium (a non-steroidal anti-inflammatory drug) was found to be more effective than diclofenac sodium alone on the sequelae of surgical removal of impacted mandibular third molar.

No MeSH data available.


Related in: MedlinePlus