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C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum--a single center pilot study.

Hobusch GM, Bodner F, Walzer S, Marculescu R, Funovics PT, Sulzbacher I, Windhager R, Panotopoulos J - World J Surg Oncol (2016)

Bottom Line: Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival?CRP remained as an independent survival factor (p = 0.025; CI 95% 1.0-2.6) in multivariable analysis.A validation of our finding with larger cohorts and integration of putative risk factor would further elucidate CRP a surrogate for tumor progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, Medical University of Vienna, Waehringer Guertel 18 - 20, A-1090, Wien, Austria. gerhard.hobusch@meduniwien.ac.at.

ABSTRACT

Study design: This is a retrospective, diagnostic study, level IV.

Background: It appears to be necessary to identify prognostic markers for individual risk estimation for progression and survival in patients with chordoma, a rare disease. Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival?

Methods: Survival rates of 24 patients (18 males, 6 females) (mean age 67 years (SD ± 16; range 20-85 years); minimum follow-up 2 years, mean follow-up 5 years (SD ± 5; range 2-19 years)) with chordoma of the lower spine and sacrum were assessed with a focus on pre-operative CRP levels.

Results: The survival rate of patients with pre-operative CRP level of >1.0 mg/dl was lower than that of patients with a CRP level <1.0 mg/dl (p = 0.01). The estimated 10-year survival of patients with pre-operative CRP values <1.0 and >1.0 mg/dl was 76 and 25%, respectively. CRP remained as an independent survival factor (p = 0.025; CI 95% 1.0-2.6) in multivariable analysis.

Conclusions: Pre-operative CRP levels appear to be a biomarker for disease-specific survival in patients with chordoma of the lumbar spine and sacrum. A validation of our finding with larger cohorts and integration of putative risk factor would further elucidate CRP a surrogate for tumor progression.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier curves overall survival categorized into pre-operative CRP levels <1.0 and >1.0 mg/dl
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Fig1: Kaplan-Meier curves overall survival categorized into pre-operative CRP levels <1.0 and >1.0 mg/dl

Mentions: Patients with a pre-operative CRP level of >1.0 mg/dl had a lower survival rate than patients with a CRP level <1.0 mg/dl (p = 0.01) (Fig. 1). The estimated 2-, 5-, and 10-year survival of patients with pre-operative CRP values <1.0 mg/dl was 87, 76, and 76 % with >1.0 mg/dl 62, 25, and 25 % respectively.Fig. 1


C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum--a single center pilot study.

Hobusch GM, Bodner F, Walzer S, Marculescu R, Funovics PT, Sulzbacher I, Windhager R, Panotopoulos J - World J Surg Oncol (2016)

Kaplan-Meier curves overall survival categorized into pre-operative CRP levels <1.0 and >1.0 mg/dl
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4836072&req=5

Fig1: Kaplan-Meier curves overall survival categorized into pre-operative CRP levels <1.0 and >1.0 mg/dl
Mentions: Patients with a pre-operative CRP level of >1.0 mg/dl had a lower survival rate than patients with a CRP level <1.0 mg/dl (p = 0.01) (Fig. 1). The estimated 2-, 5-, and 10-year survival of patients with pre-operative CRP values <1.0 mg/dl was 87, 76, and 76 % with >1.0 mg/dl 62, 25, and 25 % respectively.Fig. 1

Bottom Line: Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival?CRP remained as an independent survival factor (p = 0.025; CI 95% 1.0-2.6) in multivariable analysis.A validation of our finding with larger cohorts and integration of putative risk factor would further elucidate CRP a surrogate for tumor progression.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedics, Medical University of Vienna, Waehringer Guertel 18 - 20, A-1090, Wien, Austria. gerhard.hobusch@meduniwien.ac.at.

ABSTRACT

Study design: This is a retrospective, diagnostic study, level IV.

Background: It appears to be necessary to identify prognostic markers for individual risk estimation for progression and survival in patients with chordoma, a rare disease. Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival?

Methods: Survival rates of 24 patients (18 males, 6 females) (mean age 67 years (SD ± 16; range 20-85 years); minimum follow-up 2 years, mean follow-up 5 years (SD ± 5; range 2-19 years)) with chordoma of the lower spine and sacrum were assessed with a focus on pre-operative CRP levels.

Results: The survival rate of patients with pre-operative CRP level of >1.0 mg/dl was lower than that of patients with a CRP level <1.0 mg/dl (p = 0.01). The estimated 10-year survival of patients with pre-operative CRP values <1.0 and >1.0 mg/dl was 76 and 25%, respectively. CRP remained as an independent survival factor (p = 0.025; CI 95% 1.0-2.6) in multivariable analysis.

Conclusions: Pre-operative CRP levels appear to be a biomarker for disease-specific survival in patients with chordoma of the lumbar spine and sacrum. A validation of our finding with larger cohorts and integration of putative risk factor would further elucidate CRP a surrogate for tumor progression.

No MeSH data available.


Related in: MedlinePlus