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Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula.

Al-Marby A, Ejike CE, Nasim MJ, Awadh-Ali NA, Al-Badani RA, Alghamdi GM, Jacob C - J Intercult Ethnopharmacol (2016)

Bottom Line: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations.Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml.The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Bioorganic Chemistry, University of Saarland, Campus B2 1, D-66123 Saarbruecken, Saarland, Germany.

ABSTRACT

Aim/background: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities.

Materials and methods: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated.

Results: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12-15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml.

Conclusion: The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

No MeSH data available.


Related in: MedlinePlus

The plants which exhibited the highest toxicity against the selected microorganisms
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Figure 3: The plants which exhibited the highest toxicity against the selected microorganisms

Mentions: The data generated was subjected to descriptive statistical analysis and the results are presented as mean ± standard error of mean. Differences between the means (test versus control) were assessed for statistical significance using the one-way ANOVA test with the significance threshold fixed at P < 0.05. The GraphPad Prism software (GraphPad Inc., USA) was used for all statistical analyzes. The results are presented in Tables 1-3 and Figures 1-3 and statistical significances in the Figures 1-3 are marked as *, **, or *** when the P < 0.05, < 0.01 or < 0.001, respectively.


Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula.

Al-Marby A, Ejike CE, Nasim MJ, Awadh-Ali NA, Al-Badani RA, Alghamdi GM, Jacob C - J Intercult Ethnopharmacol (2016)

The plants which exhibited the highest toxicity against the selected microorganisms
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835985&req=5

Figure 3: The plants which exhibited the highest toxicity against the selected microorganisms
Mentions: The data generated was subjected to descriptive statistical analysis and the results are presented as mean ± standard error of mean. Differences between the means (test versus control) were assessed for statistical significance using the one-way ANOVA test with the significance threshold fixed at P < 0.05. The GraphPad Prism software (GraphPad Inc., USA) was used for all statistical analyzes. The results are presented in Tables 1-3 and Figures 1-3 and statistical significances in the Figures 1-3 are marked as *, **, or *** when the P < 0.05, < 0.01 or < 0.001, respectively.

Bottom Line: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations.Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml.The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Bioorganic Chemistry, University of Saarland, Campus B2 1, D-66123 Saarbruecken, Saarland, Germany.

ABSTRACT

Aim/background: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities.

Materials and methods: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated.

Results: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12-15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml.

Conclusion: The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

No MeSH data available.


Related in: MedlinePlus