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Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula.

Al-Marby A, Ejike CE, Nasim MJ, Awadh-Ali NA, Al-Badani RA, Alghamdi GM, Jacob C - J Intercult Ethnopharmacol (2016)

Bottom Line: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations.Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml.The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Bioorganic Chemistry, University of Saarland, Campus B2 1, D-66123 Saarbruecken, Saarland, Germany.

ABSTRACT

Aim/background: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities.

Materials and methods: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated.

Results: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12-15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml.

Conclusion: The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

No MeSH data available.


Related in: MedlinePlus

Map of Arabian Peninsula indicating the regions of plant collection
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Figure 1: Map of Arabian Peninsula indicating the regions of plant collection

Mentions: In the light of the above, the nematicidal and antimicrobial properties of methanol extracts of 17 plants used in ethnopharmacology and ethnomedicine around the tropics and sub-tropics, and particularly in Saudi Arabia and Yemen were investigated [Figure 1]. The primary aim of this investigation has been to uncover phytochemical products that can be produced locally and in sufficient commercial quantities to be used in improving Medicine and Agriculture, especially in some of the developing economies of the world. Details of the plants, the parts harvested and their uses in folk medicine have been obtained from published literature, and traditional users of the plants [14-16] are summarized in Table 1.


Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula.

Al-Marby A, Ejike CE, Nasim MJ, Awadh-Ali NA, Al-Badani RA, Alghamdi GM, Jacob C - J Intercult Ethnopharmacol (2016)

Map of Arabian Peninsula indicating the regions of plant collection
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835985&req=5

Figure 1: Map of Arabian Peninsula indicating the regions of plant collection
Mentions: In the light of the above, the nematicidal and antimicrobial properties of methanol extracts of 17 plants used in ethnopharmacology and ethnomedicine around the tropics and sub-tropics, and particularly in Saudi Arabia and Yemen were investigated [Figure 1]. The primary aim of this investigation has been to uncover phytochemical products that can be produced locally and in sufficient commercial quantities to be used in improving Medicine and Agriculture, especially in some of the developing economies of the world. Details of the plants, the parts harvested and their uses in folk medicine have been obtained from published literature, and traditional users of the plants [14-16] are summarized in Table 1.

Bottom Line: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations.Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml.The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Bioorganic Chemistry, University of Saarland, Campus B2 1, D-66123 Saarbruecken, Saarland, Germany.

ABSTRACT

Aim/background: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities.

Materials and methods: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays. Steinernema feltiae, Staphylococcus carnosus, Escherichia coli, and Saccharomyces cerevisiae were used as test organisms. Concentrations of the extracts ranging from 0.5 to 20 mg/ml were tested and appropriate statistical tests performed on the data generated.

Results: The results show that extracts from Solanum incanum, Chenopodium murale, Commiphora myrrha, Anthemis nobilis, and Achillea biebersteinii were the most active and had very high activities against two or more of the test organisms at low concentrations. Extracts of the leaves of S. incanum and resins of Ferula asafoetida were the most active nematicides, with significant activity at 0.5 mg/ml. Extracts of C. myrrha and C. murale had the most active antibacterial activity with inhibition zones of 12-15 mm and minimum inhibitory concentrations (MICs) of 2.5 mg/ml for both bacteria. Extracts of the leaves of A. biebersteinii were the most active fungicide, giving an MIC of 1.5 mg/ml.

Conclusion: The results validate the use of these plants in ethnopharmacology, and open new vistas of opportunities for the development of cheap but effective agents that may be useful against infectious diseases.

No MeSH data available.


Related in: MedlinePlus