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De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma: pathogenesis revisited.

Yaghmour W, Kurdi ME, Baeesa SS - World J Surg Oncol (2016)

Bottom Line: We are reporting a 32-year-old male who developed left middle cerebral artery (MCA) infarction as a surgical complication for sphenoid meningioma.He developed recurrent symptoms 4 months later due to development of a glioblastoma adjacent to both the territory of the prior MCA infarct and the residual meningioma.This case adds further contribution to the literature of the possible pathological association between glioblastoma and brain infarction on a background of meningioma.

View Article: PubMed Central - PubMed

Affiliation: Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.

ABSTRACT

Background: The pathogenesis of glioblastoma is complex, and the implicated molecular mechanisms are yet to be understood. There are scattered reports describing a possible relationship between meningioma and glioblastoma and more rarely a relationship between infarction and glioblastoma.

Case presentation: We are reporting a 32-year-old male who developed left middle cerebral artery (MCA) infarction as a surgical complication for sphenoid meningioma. He developed recurrent symptoms 4 months later due to development of a glioblastoma adjacent to both the territory of the prior MCA infarct and the residual meningioma.

Conclusions: This case adds further contribution to the literature of the possible pathological association between glioblastoma and brain infarction on a background of meningioma.

No MeSH data available.


Related in: MedlinePlus

MRI study performed 5 months from the first surgery. Post-contrast parasagittal (a), coronal (b), and axial (c, d) MRI scans were performed demonstrating no change in the size of the meningioma, but there are multiple ring enhancing lesions in the medial temporal lobe adjacent to the meningioma, and in the infarcted tissue involving the corpus callosum
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Fig4: MRI study performed 5 months from the first surgery. Post-contrast parasagittal (a), coronal (b), and axial (c, d) MRI scans were performed demonstrating no change in the size of the meningioma, but there are multiple ring enhancing lesions in the medial temporal lobe adjacent to the meningioma, and in the infarcted tissue involving the corpus callosum

Mentions: His second presentation to the emergency department, 3 weeks prior his scheduled admission, was with progressive headache over 2 weeks. He was confused with worsened speech and right hemiparesis. Brain MRI scan revealed unchanged size of the residual meningioma and the previous infarction, but there were new enhancing multi-focal and multi-centric deep frontotemporal lesions within and adjacent to the infarcted region and adjacent to the residual meningioma (Fig. 4). The extent of the edema and the new tumor infiltration was demonstrated by FLAIR MRI scan which involved the left hemisphere and extended to the right side as well (Fig. 5). The patient was admitted and started on steroids and had a stereotactic biopsy of the enhancing part of the new frontal lobe lesions.Fig. 4


De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma: pathogenesis revisited.

Yaghmour W, Kurdi ME, Baeesa SS - World J Surg Oncol (2016)

MRI study performed 5 months from the first surgery. Post-contrast parasagittal (a), coronal (b), and axial (c, d) MRI scans were performed demonstrating no change in the size of the meningioma, but there are multiple ring enhancing lesions in the medial temporal lobe adjacent to the meningioma, and in the infarcted tissue involving the corpus callosum
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4835844&req=5

Fig4: MRI study performed 5 months from the first surgery. Post-contrast parasagittal (a), coronal (b), and axial (c, d) MRI scans were performed demonstrating no change in the size of the meningioma, but there are multiple ring enhancing lesions in the medial temporal lobe adjacent to the meningioma, and in the infarcted tissue involving the corpus callosum
Mentions: His second presentation to the emergency department, 3 weeks prior his scheduled admission, was with progressive headache over 2 weeks. He was confused with worsened speech and right hemiparesis. Brain MRI scan revealed unchanged size of the residual meningioma and the previous infarction, but there were new enhancing multi-focal and multi-centric deep frontotemporal lesions within and adjacent to the infarcted region and adjacent to the residual meningioma (Fig. 4). The extent of the edema and the new tumor infiltration was demonstrated by FLAIR MRI scan which involved the left hemisphere and extended to the right side as well (Fig. 5). The patient was admitted and started on steroids and had a stereotactic biopsy of the enhancing part of the new frontal lobe lesions.Fig. 4

Bottom Line: We are reporting a 32-year-old male who developed left middle cerebral artery (MCA) infarction as a surgical complication for sphenoid meningioma.He developed recurrent symptoms 4 months later due to development of a glioblastoma adjacent to both the territory of the prior MCA infarct and the residual meningioma.This case adds further contribution to the literature of the possible pathological association between glioblastoma and brain infarction on a background of meningioma.

View Article: PubMed Central - PubMed

Affiliation: Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.

ABSTRACT

Background: The pathogenesis of glioblastoma is complex, and the implicated molecular mechanisms are yet to be understood. There are scattered reports describing a possible relationship between meningioma and glioblastoma and more rarely a relationship between infarction and glioblastoma.

Case presentation: We are reporting a 32-year-old male who developed left middle cerebral artery (MCA) infarction as a surgical complication for sphenoid meningioma. He developed recurrent symptoms 4 months later due to development of a glioblastoma adjacent to both the territory of the prior MCA infarct and the residual meningioma.

Conclusions: This case adds further contribution to the literature of the possible pathological association between glioblastoma and brain infarction on a background of meningioma.

No MeSH data available.


Related in: MedlinePlus