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Health Effects of PCBs in Residences and Schools (HESPERUS): PCB - health Cohort Profile.

Bräuner EV, Andersen ZJ, Frederiksen M, Specht IO, Hougaard KS, Ebbehøj N, Bailey J, Giwercman A, Steenland K, Longnecker MP, Bonde JP - Sci Rep (2016)

Bottom Line: Polychlorinated-biphenyls (PCBs) were introduced in the late 1920s and used until the 1970s when they were banned in most countries due to evidence of environmental build-up and possible adverse health effects.The cohorts will be linked to eight different national data sources on mortality, school records, residential history, socioeconomic status, and chronic disease and reproductive outcomes.We describe a project, called HESPERUS (Health Effects of PCBs in Residences and Schools), which will be the first study of the long term health effects of the lower-chlorinated, semi-volatile PCBs in the indoor environment.

View Article: PubMed Central - PubMed

Affiliation: Research Center of Prevention and Health, Center of Health, Capital region of Denmark, Rigshospital - Glostrup, Copenhagen University, Denmark.

ABSTRACT
Polychlorinated-biphenyls (PCBs) were introduced in the late 1920s and used until the 1970s when they were banned in most countries due to evidence of environmental build-up and possible adverse health effects. However they still persist in the environment, indoors and in humans. Indoor air in contaminated buildings may confer airborne exposure markedly above background regional PCB levels. To date, no epidemiological studies have assessed the health effects from exposure to semi-volatile PCBs in the indoor environment. Indoor air PCBs are generally less chlorinated than PCBs that are absorbed via the diet, or via past occupational exposure; therefore their health effects require separate risk assessment. Two separate cohorts of individuals who have either attended schools (n = 66,769; 26% exposed) or lived in apartment buildings (n = 37,185; 19% exposed), where indoor air PCB concentrations have been measured were created. An individual estimate of long-term airborne PCB exposure was assigned based on measurements. The cohorts will be linked to eight different national data sources on mortality, school records, residential history, socioeconomic status, and chronic disease and reproductive outcomes. The linking of indoor air exposures with health outcomes provides a dataset unprecedented worldwide. We describe a project, called HESPERUS (Health Effects of PCBs in Residences and Schools), which will be the first study of the long term health effects of the lower-chlorinated, semi-volatile PCBs in the indoor environment.

No MeSH data available.


Related in: MedlinePlus

Geographical location of the 127 schools from school children PCB cohort and 2 social housing estates from apartment residents PCB cohort in Denmark.Generated in ArcGIS Desktop: Release 10. Redlands, CA: Environmental Systems Research Institute (ESRI) 2011 (URL: http://www.esri.com/software/arcgis/arcgis-for-desktop).
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f2: Geographical location of the 127 schools from school children PCB cohort and 2 social housing estates from apartment residents PCB cohort in Denmark.Generated in ArcGIS Desktop: Release 10. Redlands, CA: Environmental Systems Research Institute (ESRI) 2011 (URL: http://www.esri.com/software/arcgis/arcgis-for-desktop).

Mentions: We identified elementary schools with measured PCB indoor levels via contact with 22 municipalities for which we had a-priori knowledge that PCBs had been monitored in their schools (Fig. 1). These 22 municipalities were selected randomly among all municipalities where schools had been measured (n = 36), to represent different regions of Denmark. Of the 22 municipalities we contacted, 20 had performed PCB measurements in indoor air in their schools within the period 2010 to 2014 (Fig. 2), whilst 2 only performed measurements in caulking and sealants. We have now collected the PCB measurements in indoor air from all 127 schools that had available PCB measurements within these 20 municipalities (Table 2).


Health Effects of PCBs in Residences and Schools (HESPERUS): PCB - health Cohort Profile.

Bräuner EV, Andersen ZJ, Frederiksen M, Specht IO, Hougaard KS, Ebbehøj N, Bailey J, Giwercman A, Steenland K, Longnecker MP, Bonde JP - Sci Rep (2016)

Geographical location of the 127 schools from school children PCB cohort and 2 social housing estates from apartment residents PCB cohort in Denmark.Generated in ArcGIS Desktop: Release 10. Redlands, CA: Environmental Systems Research Institute (ESRI) 2011 (URL: http://www.esri.com/software/arcgis/arcgis-for-desktop).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835792&req=5

f2: Geographical location of the 127 schools from school children PCB cohort and 2 social housing estates from apartment residents PCB cohort in Denmark.Generated in ArcGIS Desktop: Release 10. Redlands, CA: Environmental Systems Research Institute (ESRI) 2011 (URL: http://www.esri.com/software/arcgis/arcgis-for-desktop).
Mentions: We identified elementary schools with measured PCB indoor levels via contact with 22 municipalities for which we had a-priori knowledge that PCBs had been monitored in their schools (Fig. 1). These 22 municipalities were selected randomly among all municipalities where schools had been measured (n = 36), to represent different regions of Denmark. Of the 22 municipalities we contacted, 20 had performed PCB measurements in indoor air in their schools within the period 2010 to 2014 (Fig. 2), whilst 2 only performed measurements in caulking and sealants. We have now collected the PCB measurements in indoor air from all 127 schools that had available PCB measurements within these 20 municipalities (Table 2).

Bottom Line: Polychlorinated-biphenyls (PCBs) were introduced in the late 1920s and used until the 1970s when they were banned in most countries due to evidence of environmental build-up and possible adverse health effects.The cohorts will be linked to eight different national data sources on mortality, school records, residential history, socioeconomic status, and chronic disease and reproductive outcomes.We describe a project, called HESPERUS (Health Effects of PCBs in Residences and Schools), which will be the first study of the long term health effects of the lower-chlorinated, semi-volatile PCBs in the indoor environment.

View Article: PubMed Central - PubMed

Affiliation: Research Center of Prevention and Health, Center of Health, Capital region of Denmark, Rigshospital - Glostrup, Copenhagen University, Denmark.

ABSTRACT
Polychlorinated-biphenyls (PCBs) were introduced in the late 1920s and used until the 1970s when they were banned in most countries due to evidence of environmental build-up and possible adverse health effects. However they still persist in the environment, indoors and in humans. Indoor air in contaminated buildings may confer airborne exposure markedly above background regional PCB levels. To date, no epidemiological studies have assessed the health effects from exposure to semi-volatile PCBs in the indoor environment. Indoor air PCBs are generally less chlorinated than PCBs that are absorbed via the diet, or via past occupational exposure; therefore their health effects require separate risk assessment. Two separate cohorts of individuals who have either attended schools (n = 66,769; 26% exposed) or lived in apartment buildings (n = 37,185; 19% exposed), where indoor air PCB concentrations have been measured were created. An individual estimate of long-term airborne PCB exposure was assigned based on measurements. The cohorts will be linked to eight different national data sources on mortality, school records, residential history, socioeconomic status, and chronic disease and reproductive outcomes. The linking of indoor air exposures with health outcomes provides a dataset unprecedented worldwide. We describe a project, called HESPERUS (Health Effects of PCBs in Residences and Schools), which will be the first study of the long term health effects of the lower-chlorinated, semi-volatile PCBs in the indoor environment.

No MeSH data available.


Related in: MedlinePlus