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Cardiac troponin T and echocardiographic dimensions after repeated sprint vs. moderate intensity continuous exercise in healthy young males.

Weippert M, Divchev D, Schmidt P, Gettel H, Neugebauer A, Behrens K, Wolfarth B, Braumann KM, Nienaber CA - Sci Rep (2016)

Bottom Line: Results showed that all variables - average heart rate, serum lactate concentration during RST, subjective exertion and cTnT after RST - were significantly higher compared to MCT.Our results provide evidence that RST contributes significantly to cTnT and CK release.This biomarker increase seems to reflect a physiological rather than a pathological phenomenon in healthy, exercising subjects.

View Article: PubMed Central - PubMed

Affiliation: Institute of Sport Science, University of Rostock, Germany.

ABSTRACT
Regular physical exercise can positively influence cardiac function; however, investigations have shown an increase of myocardial damage biomarkers after acute prolonged endurance exercises. We investigated the effect of repeated sprint vs. moderate long duration exercise on markers of myocardial necrosis, as well as cardiac dimensions and functions. Thirteen healthy males performed two different running sessions (randomized, single blinded cross-over design): 60 minutes moderate intensity continuous training (MCT, at 70% of peak heart rate (HRpeak)) and two series of 12 × 30-second sprints with set recovery periods in-between (RST, at 90% HRpeak). Venous blood samples for cardiac troponin T (cTnT), creatine kinase (CK) and MB isoenzyme (CK-MB) were taken 1 and 4 hours after exercise sessions. After each session electrocardiographic (ECG) and transthoracic echocardiographic (TTE) data were recorded. Results showed that all variables - average heart rate, serum lactate concentration during RST, subjective exertion and cTnT after RST - were significantly higher compared to MCT. CK and CK-MB significantly increased regardless of exercise protocol, while ECG and TTE indicated normal cardiac function. Our results provide evidence that RST contributes significantly to cTnT and CK release. This biomarker increase seems to reflect a physiological rather than a pathological phenomenon in healthy, exercising subjects.

No MeSH data available.


Related in: MedlinePlus

Biomarker concentration before (PRE), 1 (POST + 1) and 4 hours (POST + 4) after cessation of the different exercise protocols; *p < 0.05, **p < 0.001, dotted line = reference limit; MCT, moderate intensity continuous training; RST, repeated sprint interval training; cTnT, cardiac troponin T; CK, creatine kinase; CK-MB, CK muscle-brain isoform; %CK-MB, ratio of CK-MB: total CK in %, N = 13.
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f1: Biomarker concentration before (PRE), 1 (POST + 1) and 4 hours (POST + 4) after cessation of the different exercise protocols; *p < 0.05, **p < 0.001, dotted line = reference limit; MCT, moderate intensity continuous training; RST, repeated sprint interval training; cTnT, cardiac troponin T; CK, creatine kinase; CK-MB, CK muscle-brain isoform; %CK-MB, ratio of CK-MB: total CK in %, N = 13.

Mentions: Statistical analysis revealed a strong effect on cTnT by means of measurement time (F(1.2,14.5) = 18.43, p < 0.001, η2 = 0.606), exercise protocol (F(1,12) = 17.483, p < 0.01, η2 = 0.593) as well as their interaction (F(1.2,13.1) = 19.684, p < 0.001, η2 = 0.621). Figure 1 shows PRE, POST +1 and POST +4 biomarker concentrations and significance levels for the post hoc pair wise comparisons. CTnT significantly increased 4 hours after exercise; a statistical trend was evident for POST +1. In five out of the thirteen participants, cTnT exceeded the clinical limit of normal.


Cardiac troponin T and echocardiographic dimensions after repeated sprint vs. moderate intensity continuous exercise in healthy young males.

Weippert M, Divchev D, Schmidt P, Gettel H, Neugebauer A, Behrens K, Wolfarth B, Braumann KM, Nienaber CA - Sci Rep (2016)

Biomarker concentration before (PRE), 1 (POST + 1) and 4 hours (POST + 4) after cessation of the different exercise protocols; *p < 0.05, **p < 0.001, dotted line = reference limit; MCT, moderate intensity continuous training; RST, repeated sprint interval training; cTnT, cardiac troponin T; CK, creatine kinase; CK-MB, CK muscle-brain isoform; %CK-MB, ratio of CK-MB: total CK in %, N = 13.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835763&req=5

f1: Biomarker concentration before (PRE), 1 (POST + 1) and 4 hours (POST + 4) after cessation of the different exercise protocols; *p < 0.05, **p < 0.001, dotted line = reference limit; MCT, moderate intensity continuous training; RST, repeated sprint interval training; cTnT, cardiac troponin T; CK, creatine kinase; CK-MB, CK muscle-brain isoform; %CK-MB, ratio of CK-MB: total CK in %, N = 13.
Mentions: Statistical analysis revealed a strong effect on cTnT by means of measurement time (F(1.2,14.5) = 18.43, p < 0.001, η2 = 0.606), exercise protocol (F(1,12) = 17.483, p < 0.01, η2 = 0.593) as well as their interaction (F(1.2,13.1) = 19.684, p < 0.001, η2 = 0.621). Figure 1 shows PRE, POST +1 and POST +4 biomarker concentrations and significance levels for the post hoc pair wise comparisons. CTnT significantly increased 4 hours after exercise; a statistical trend was evident for POST +1. In five out of the thirteen participants, cTnT exceeded the clinical limit of normal.

Bottom Line: Results showed that all variables - average heart rate, serum lactate concentration during RST, subjective exertion and cTnT after RST - were significantly higher compared to MCT.Our results provide evidence that RST contributes significantly to cTnT and CK release.This biomarker increase seems to reflect a physiological rather than a pathological phenomenon in healthy, exercising subjects.

View Article: PubMed Central - PubMed

Affiliation: Institute of Sport Science, University of Rostock, Germany.

ABSTRACT
Regular physical exercise can positively influence cardiac function; however, investigations have shown an increase of myocardial damage biomarkers after acute prolonged endurance exercises. We investigated the effect of repeated sprint vs. moderate long duration exercise on markers of myocardial necrosis, as well as cardiac dimensions and functions. Thirteen healthy males performed two different running sessions (randomized, single blinded cross-over design): 60 minutes moderate intensity continuous training (MCT, at 70% of peak heart rate (HRpeak)) and two series of 12 × 30-second sprints with set recovery periods in-between (RST, at 90% HRpeak). Venous blood samples for cardiac troponin T (cTnT), creatine kinase (CK) and MB isoenzyme (CK-MB) were taken 1 and 4 hours after exercise sessions. After each session electrocardiographic (ECG) and transthoracic echocardiographic (TTE) data were recorded. Results showed that all variables - average heart rate, serum lactate concentration during RST, subjective exertion and cTnT after RST - were significantly higher compared to MCT. CK and CK-MB significantly increased regardless of exercise protocol, while ECG and TTE indicated normal cardiac function. Our results provide evidence that RST contributes significantly to cTnT and CK release. This biomarker increase seems to reflect a physiological rather than a pathological phenomenon in healthy, exercising subjects.

No MeSH data available.


Related in: MedlinePlus