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Cell-targeting antibodies in immunity to Ebola.

Schmaljohn A, Lewis GK - Pathog Dis (2016)

Bottom Line: To be clear, many NAbs are also CTAbs, and in the case of Ebola the great majority of NAbs are likely CTAbs.Isotype, glycosylation, and other features of CTAbs are likely crucial in their capacity to mediate protection.Overall, results and analysis invite an increasingly complex view of antibody-mediated immunity to enveloped viruses.

View Article: PubMed Central - PubMed

Affiliation: Microbiology & Immunology, University of Maryland School of Medicine, USA aschmaljohn@som.umaryland.edu.

No MeSH data available.


Related in: MedlinePlus

Immunity to Ebola and other enveloped viruses often involves cell-targeting antibodies, which mark virus-infected cells for Fc-dependent immune attack and entail previously underappreciated complexities of Fc type and Fc–FcR interaction.
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fig1g: Immunity to Ebola and other enveloped viruses often involves cell-targeting antibodies, which mark virus-infected cells for Fc-dependent immune attack and entail previously underappreciated complexities of Fc type and Fc–FcR interaction.


Cell-targeting antibodies in immunity to Ebola.

Schmaljohn A, Lewis GK - Pathog Dis (2016)

Immunity to Ebola and other enveloped viruses often involves cell-targeting antibodies, which mark virus-infected cells for Fc-dependent immune attack and entail previously underappreciated complexities of Fc type and Fc–FcR interaction.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835745&req=5

fig1g: Immunity to Ebola and other enveloped viruses often involves cell-targeting antibodies, which mark virus-infected cells for Fc-dependent immune attack and entail previously underappreciated complexities of Fc type and Fc–FcR interaction.
Bottom Line: To be clear, many NAbs are also CTAbs, and in the case of Ebola the great majority of NAbs are likely CTAbs.Isotype, glycosylation, and other features of CTAbs are likely crucial in their capacity to mediate protection.Overall, results and analysis invite an increasingly complex view of antibody-mediated immunity to enveloped viruses.

View Article: PubMed Central - PubMed

Affiliation: Microbiology & Immunology, University of Maryland School of Medicine, USA aschmaljohn@som.umaryland.edu.

No MeSH data available.


Related in: MedlinePlus