Cell-targeting antibodies in immunity to Ebola.
Bottom Line:
To be clear, many NAbs are also CTAbs, and in the case of Ebola the great majority of NAbs are likely CTAbs.Isotype, glycosylation, and other features of CTAbs are likely crucial in their capacity to mediate protection.Overall, results and analysis invite an increasingly complex view of antibody-mediated immunity to enveloped viruses.
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PubMed Central - PubMed
Affiliation: Microbiology & Immunology, University of Maryland School of Medicine, USA aschmaljohn@som.umaryland.edu.
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fig1g: Immunity to Ebola and other enveloped viruses often involves cell-targeting antibodies, which mark virus-infected cells for Fc-dependent immune attack and entail previously underappreciated complexities of Fc type and Fc–FcR interaction. |
View Article: PubMed Central - PubMed
Affiliation: Microbiology & Immunology, University of Maryland School of Medicine, USA aschmaljohn@som.umaryland.edu.