Limits...
The effects of a low-energy, high frequency liquid optic interface femtosecond laser system on lens capsulotomy.

Williams GP, George BL, Wong YR, Seah XY, Ang HP, Loke MK, Tay SC, Mehta JS - Sci Rep (2016)

Bottom Line: The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture.In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable.The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

View Article: PubMed Central - PubMed

Affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

ABSTRACT
The introduction of femtosecond laser assisted cataract surgery (FLACS) is a paradigm changing approach in cataract surgery, the most commonly performed surgical procedure. FLACS has the potential to optimize the creation of an anterior lens capsulotomy, a critical step in accessing the cataractous lens. The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture. In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable. While there was no demonstrable difference in the resistance to rupture before or after the removal of the nucleus, larger capsulotomies had an increase in tensile strength. The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

No MeSH data available.


Related in: MedlinePlus

Human lens capsule circularity, edge and strength.Human lenses were removed with nucleus intact and circularity (A) and elasticity (B) of the capsule were evaluated (n = 12). Scanning electron microscopy (SEM) images of capsule edge by manual and Z8 created approach (C). The inset image is at ×750 magnification (line denotes 10 um) and the larger image at ×4000 (line denotes 1 um) and the capsule edge is arrowed. Resistance of the capsulotomy to rupture was measured in mN and the stretching ratio by (size mm + displacement mm)/size. Two mushroom shaped pins were placed posterior to the capsulotomy edge and the rate of pin displacement was set at 6 mm/min. Comparison between strength and stretch ratio by porcine Z8, human manual or human Z8 are shown in (D) (n = 14). **p < 0.01. NS = Not Significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4835735&req=5

f4: Human lens capsule circularity, edge and strength.Human lenses were removed with nucleus intact and circularity (A) and elasticity (B) of the capsule were evaluated (n = 12). Scanning electron microscopy (SEM) images of capsule edge by manual and Z8 created approach (C). The inset image is at ×750 magnification (line denotes 10 um) and the larger image at ×4000 (line denotes 1 um) and the capsule edge is arrowed. Resistance of the capsulotomy to rupture was measured in mN and the stretching ratio by (size mm + displacement mm)/size. Two mushroom shaped pins were placed posterior to the capsulotomy edge and the rate of pin displacement was set at 6 mm/min. Comparison between strength and stretch ratio by porcine Z8, human manual or human Z8 are shown in (D) (n = 14). **p < 0.01. NS = Not Significant.

Mentions: Median circularity 0.97[0.96–0.99] (n = 6) was comparable to the Z8 0.98[0.97–0.99] (n = 6) (p = 0.3) but with a slight increase in variability with manual cuts (Fig. 4A). Manual accuracy was also less predictable than with the Z8, with capsules measured at 3.17 mm[3.12–3.31] (p = 0.25) and 3.72 mm[3.58–3.94] (p = 0.05) representing a deviation from intended 4 mm size approximating 0.8 mm with manual and 0.25 mm with the Z8.


The effects of a low-energy, high frequency liquid optic interface femtosecond laser system on lens capsulotomy.

Williams GP, George BL, Wong YR, Seah XY, Ang HP, Loke MK, Tay SC, Mehta JS - Sci Rep (2016)

Human lens capsule circularity, edge and strength.Human lenses were removed with nucleus intact and circularity (A) and elasticity (B) of the capsule were evaluated (n = 12). Scanning electron microscopy (SEM) images of capsule edge by manual and Z8 created approach (C). The inset image is at ×750 magnification (line denotes 10 um) and the larger image at ×4000 (line denotes 1 um) and the capsule edge is arrowed. Resistance of the capsulotomy to rupture was measured in mN and the stretching ratio by (size mm + displacement mm)/size. Two mushroom shaped pins were placed posterior to the capsulotomy edge and the rate of pin displacement was set at 6 mm/min. Comparison between strength and stretch ratio by porcine Z8, human manual or human Z8 are shown in (D) (n = 14). **p < 0.01. NS = Not Significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835735&req=5

f4: Human lens capsule circularity, edge and strength.Human lenses were removed with nucleus intact and circularity (A) and elasticity (B) of the capsule were evaluated (n = 12). Scanning electron microscopy (SEM) images of capsule edge by manual and Z8 created approach (C). The inset image is at ×750 magnification (line denotes 10 um) and the larger image at ×4000 (line denotes 1 um) and the capsule edge is arrowed. Resistance of the capsulotomy to rupture was measured in mN and the stretching ratio by (size mm + displacement mm)/size. Two mushroom shaped pins were placed posterior to the capsulotomy edge and the rate of pin displacement was set at 6 mm/min. Comparison between strength and stretch ratio by porcine Z8, human manual or human Z8 are shown in (D) (n = 14). **p < 0.01. NS = Not Significant.
Mentions: Median circularity 0.97[0.96–0.99] (n = 6) was comparable to the Z8 0.98[0.97–0.99] (n = 6) (p = 0.3) but with a slight increase in variability with manual cuts (Fig. 4A). Manual accuracy was also less predictable than with the Z8, with capsules measured at 3.17 mm[3.12–3.31] (p = 0.25) and 3.72 mm[3.58–3.94] (p = 0.05) representing a deviation from intended 4 mm size approximating 0.8 mm with manual and 0.25 mm with the Z8.

Bottom Line: The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture.In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable.The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

View Article: PubMed Central - PubMed

Affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

ABSTRACT
The introduction of femtosecond laser assisted cataract surgery (FLACS) is a paradigm changing approach in cataract surgery, the most commonly performed surgical procedure. FLACS has the potential to optimize the creation of an anterior lens capsulotomy, a critical step in accessing the cataractous lens. The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture. In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable. While there was no demonstrable difference in the resistance to rupture before or after the removal of the nucleus, larger capsulotomies had an increase in tensile strength. The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

No MeSH data available.


Related in: MedlinePlus