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The effects of a low-energy, high frequency liquid optic interface femtosecond laser system on lens capsulotomy.

Williams GP, George BL, Wong YR, Seah XY, Ang HP, Loke MK, Tay SC, Mehta JS - Sci Rep (2016)

Bottom Line: The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture.In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable.The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

View Article: PubMed Central - PubMed

Affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

ABSTRACT
The introduction of femtosecond laser assisted cataract surgery (FLACS) is a paradigm changing approach in cataract surgery, the most commonly performed surgical procedure. FLACS has the potential to optimize the creation of an anterior lens capsulotomy, a critical step in accessing the cataractous lens. The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture. In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable. While there was no demonstrable difference in the resistance to rupture before or after the removal of the nucleus, larger capsulotomies had an increase in tensile strength. The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

No MeSH data available.


Related in: MedlinePlus

Lens capsule strength at 4, 5 and 6 mm capsulotomy with and without nucleus.Lenses were removed with nucleus intact and resistance of the capsulotomy to rupture was measured in mN and the stretching ratio by (size mm + displacement mm)/size. Two mushroom shaped pins were placed posterior to the capsulotomy edge and the rate of pin displacement was set at 6 mm/min (A). Comparison between strength and stretch ratio at 4, 5 and 6 mm are shown in in (B,C) (n = 18). Experiments were repeated following removal of nucleus (D–F) (n = 18) *p < 0.05 and **p < 0.01.
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f3: Lens capsule strength at 4, 5 and 6 mm capsulotomy with and without nucleus.Lenses were removed with nucleus intact and resistance of the capsulotomy to rupture was measured in mN and the stretching ratio by (size mm + displacement mm)/size. Two mushroom shaped pins were placed posterior to the capsulotomy edge and the rate of pin displacement was set at 6 mm/min (A). Comparison between strength and stretch ratio at 4, 5 and 6 mm are shown in in (B,C) (n = 18). Experiments were repeated following removal of nucleus (D–F) (n = 18) *p < 0.05 and **p < 0.01.

Mentions: There was an incremental increase in capsule tension strength from 4 to 5 to 6 mm capsulotomy with intact nucleus, measured at a median of 78.1 mN[range 73.4–107.7] vs. 116.7[108.9–133.5] vs. 138.3[89.9–175.9] (n = 18); <0.001) with a 4 mm capsulotomy showing significant reduction in resistance to rupture compared to 5 or 6 mm openings (Fig. 3A–C). A higher stretch ratio was observed with a larger capsulotomy, measured at 2.2[1.9–2.24] vs. 2.2[2.0–2.4] vs. 2.5[2.4–2.6] in the 4, 5 and 6 mm groups (n = 18); <0.01).


The effects of a low-energy, high frequency liquid optic interface femtosecond laser system on lens capsulotomy.

Williams GP, George BL, Wong YR, Seah XY, Ang HP, Loke MK, Tay SC, Mehta JS - Sci Rep (2016)

Lens capsule strength at 4, 5 and 6 mm capsulotomy with and without nucleus.Lenses were removed with nucleus intact and resistance of the capsulotomy to rupture was measured in mN and the stretching ratio by (size mm + displacement mm)/size. Two mushroom shaped pins were placed posterior to the capsulotomy edge and the rate of pin displacement was set at 6 mm/min (A). Comparison between strength and stretch ratio at 4, 5 and 6 mm are shown in in (B,C) (n = 18). Experiments were repeated following removal of nucleus (D–F) (n = 18) *p < 0.05 and **p < 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835735&req=5

f3: Lens capsule strength at 4, 5 and 6 mm capsulotomy with and without nucleus.Lenses were removed with nucleus intact and resistance of the capsulotomy to rupture was measured in mN and the stretching ratio by (size mm + displacement mm)/size. Two mushroom shaped pins were placed posterior to the capsulotomy edge and the rate of pin displacement was set at 6 mm/min (A). Comparison between strength and stretch ratio at 4, 5 and 6 mm are shown in in (B,C) (n = 18). Experiments were repeated following removal of nucleus (D–F) (n = 18) *p < 0.05 and **p < 0.01.
Mentions: There was an incremental increase in capsule tension strength from 4 to 5 to 6 mm capsulotomy with intact nucleus, measured at a median of 78.1 mN[range 73.4–107.7] vs. 116.7[108.9–133.5] vs. 138.3[89.9–175.9] (n = 18); <0.001) with a 4 mm capsulotomy showing significant reduction in resistance to rupture compared to 5 or 6 mm openings (Fig. 3A–C). A higher stretch ratio was observed with a larger capsulotomy, measured at 2.2[1.9–2.24] vs. 2.2[2.0–2.4] vs. 2.5[2.4–2.6] in the 4, 5 and 6 mm groups (n = 18); <0.01).

Bottom Line: The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture.In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable.The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

View Article: PubMed Central - PubMed

Affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

ABSTRACT
The introduction of femtosecond laser assisted cataract surgery (FLACS) is a paradigm changing approach in cataract surgery, the most commonly performed surgical procedure. FLACS has the potential to optimize the creation of an anterior lens capsulotomy, a critical step in accessing the cataractous lens. The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture. In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable. While there was no demonstrable difference in the resistance to rupture before or after the removal of the nucleus, larger capsulotomies had an increase in tensile strength. The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

No MeSH data available.


Related in: MedlinePlus