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The effects of a low-energy, high frequency liquid optic interface femtosecond laser system on lens capsulotomy.

Williams GP, George BL, Wong YR, Seah XY, Ang HP, Loke MK, Tay SC, Mehta JS - Sci Rep (2016)

Bottom Line: The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture.In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable.The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

View Article: PubMed Central - PubMed

Affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

ABSTRACT
The introduction of femtosecond laser assisted cataract surgery (FLACS) is a paradigm changing approach in cataract surgery, the most commonly performed surgical procedure. FLACS has the potential to optimize the creation of an anterior lens capsulotomy, a critical step in accessing the cataractous lens. The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture. In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable. While there was no demonstrable difference in the resistance to rupture before or after the removal of the nucleus, larger capsulotomies had an increase in tensile strength. The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

No MeSH data available.


Related in: MedlinePlus

Capsule retrieval, time to completion and circularity.Color photographs showing the capsulotomy and fragmentation pattern in situ, retrieval, measurement and mounting of lens capsule prior to preparation for scanning electron microscopy (A). The intended and actual size of capsulotomy (upper panel) and capsule (lower panel) (B). Representative photographs of lens capsule circularity at 4, 5 and 6 mm (n = 18) (C) and showing comparison at different sizes (n = 15) (D). **p < 0.01, NS = Not Significant
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f1: Capsule retrieval, time to completion and circularity.Color photographs showing the capsulotomy and fragmentation pattern in situ, retrieval, measurement and mounting of lens capsule prior to preparation for scanning electron microscopy (A). The intended and actual size of capsulotomy (upper panel) and capsule (lower panel) (B). Representative photographs of lens capsule circularity at 4, 5 and 6 mm (n = 18) (C) and showing comparison at different sizes (n = 15) (D). **p < 0.01, NS = Not Significant

Mentions: All procedures were completed successfully without complication. A consistently larger capsulotomy size than programmed (4 mm vs. 5.3 mm, 5 mm vs. 6.7 mm, 6 mm vs. 7.7 mm; p < 0.05) was observed (n = 18) (Fig. 1A,B). A commensurate shrinkage size in the capsule was observed (4 mm vs. 3.5 mm, 5 mm vs. 4.45 mm, 6 mm vs. 5.6 mm; n = 18 p < 0.05), reflecting porcine lens elasticity. The lens capsule circularity achieved was 0.98 [n = 15; range 0.95–0.99] with no demonstrable influence of size with larger capsulotomy (p = 0.23) (Fig. 1C,D).


The effects of a low-energy, high frequency liquid optic interface femtosecond laser system on lens capsulotomy.

Williams GP, George BL, Wong YR, Seah XY, Ang HP, Loke MK, Tay SC, Mehta JS - Sci Rep (2016)

Capsule retrieval, time to completion and circularity.Color photographs showing the capsulotomy and fragmentation pattern in situ, retrieval, measurement and mounting of lens capsule prior to preparation for scanning electron microscopy (A). The intended and actual size of capsulotomy (upper panel) and capsule (lower panel) (B). Representative photographs of lens capsule circularity at 4, 5 and 6 mm (n = 18) (C) and showing comparison at different sizes (n = 15) (D). **p < 0.01, NS = Not Significant
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835735&req=5

f1: Capsule retrieval, time to completion and circularity.Color photographs showing the capsulotomy and fragmentation pattern in situ, retrieval, measurement and mounting of lens capsule prior to preparation for scanning electron microscopy (A). The intended and actual size of capsulotomy (upper panel) and capsule (lower panel) (B). Representative photographs of lens capsule circularity at 4, 5 and 6 mm (n = 18) (C) and showing comparison at different sizes (n = 15) (D). **p < 0.01, NS = Not Significant
Mentions: All procedures were completed successfully without complication. A consistently larger capsulotomy size than programmed (4 mm vs. 5.3 mm, 5 mm vs. 6.7 mm, 6 mm vs. 7.7 mm; p < 0.05) was observed (n = 18) (Fig. 1A,B). A commensurate shrinkage size in the capsule was observed (4 mm vs. 3.5 mm, 5 mm vs. 4.45 mm, 6 mm vs. 5.6 mm; n = 18 p < 0.05), reflecting porcine lens elasticity. The lens capsule circularity achieved was 0.98 [n = 15; range 0.95–0.99] with no demonstrable influence of size with larger capsulotomy (p = 0.23) (Fig. 1C,D).

Bottom Line: The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture.In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable.The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

View Article: PubMed Central - PubMed

Affiliation: Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

ABSTRACT
The introduction of femtosecond laser assisted cataract surgery (FLACS) is a paradigm changing approach in cataract surgery, the most commonly performed surgical procedure. FLACS has the potential to optimize the creation of an anterior lens capsulotomy, a critical step in accessing the cataractous lens. The merits of using a laser instead of a manual approach include a potentially more circular, consistent, and stronger aperture. In this study we demonstrated for the first time in both a porcine and human experimental setting that with a low energy, high repetition FLACS system, that a circular, smooth and strong capsulotomy was achievable. While there was no demonstrable difference in the resistance to rupture before or after the removal of the nucleus, larger capsulotomies had an increase in tensile strength. The LDV Z8 system appeared to create circular, rupture-resistant and smooth capsulotomies in both porcine and more importantly human globes.

No MeSH data available.


Related in: MedlinePlus