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Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia.

Yang M, Li J, Li Y, Li R, Pang Y, Yao D, Liao W, Chen H - Sci Rep (2016)

Bottom Line: In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score.These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity.Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

View Article: PubMed Central - PubMed

Affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

ABSTRACT
Several neuroimaging studies have examined cerebral function in patients who suffer from aphasia, but the mechanism underlying this disorder remains poorly understood. In this study, we examined alterations in the local regional and remote interregional network cerebral functions in aphasia combined with amplitude of low-frequency fluctuations and interregional functional connectivity (FC) using resting-state functional magnetic resonance imaging. A total of 17 post-stroke aphasic patients, all having suffered a stroke in the left hemisphere, as well as 20 age- and sex-matched healthy controls, were enrolled in this study. The aphasic patients showed significantly increased intrinsic regional activity mainly in the contralesional mesial temporal (hippocampus/parahippocampus, [HIP/ParaHIP]) and lateral temporal cortices. In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score. Aphasic patients showed increased remote interregional FC between the contralesional HIP/ParaHIP and fusiform gyrus, but reduced FC in the ipsilesional occipital and parietal cortices. These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity. Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

No MeSH data available.


Related in: MedlinePlus

Abnormalities in the seed-based (right hippocampus/parahippocampus) functional connectivity data from aphasic patients.Brain regions showing FC differences between patients with aphasia and controls by two-sample t-test (p < 0.05 FDR-corrected and minimum cluster size of 30 voxels). Warm and cold colors indicate regions with increased and decreased FC values in aphasia, respectively. Numbers below the axial slices refer to the z-plane coordinates of the MNI space, respectively. Letters L and R correspond to the left and right sides of the brain, respectively. Further details of these regions are presented in Table 4.
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f4: Abnormalities in the seed-based (right hippocampus/parahippocampus) functional connectivity data from aphasic patients.Brain regions showing FC differences between patients with aphasia and controls by two-sample t-test (p < 0.05 FDR-corrected and minimum cluster size of 30 voxels). Warm and cold colors indicate regions with increased and decreased FC values in aphasia, respectively. Numbers below the axial slices refer to the z-plane coordinates of the MNI space, respectively. Letters L and R correspond to the left and right sides of the brain, respectively. Further details of these regions are presented in Table 4.

Mentions: The contralesional HIP/ParaHip not only show increased ALFF, but it also correlated with construction score on the ABC. Thus, the contralesional HIP/ParaHip was defined as the seed region for subsequent interregional FC analysis. Aphasic patients exhibited increased functional connectivity between the contralesional HIP/ParaHip (seed region) and the contralesional FFG (FDR corrected p < 0.05 and minimum cluster size of 30 voxels). Aphasic patients also showed reduced FC between the contralesional HIP/ParaHip and the ipsilesional middle occipital gyrus, paracentral lobule, postcentral gyrus, and middle/superior temporal pole (FDR corrected p < 0.05 and minimum cluster size of 30 voxels) (Table 4 and Fig. 4).


Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia.

Yang M, Li J, Li Y, Li R, Pang Y, Yao D, Liao W, Chen H - Sci Rep (2016)

Abnormalities in the seed-based (right hippocampus/parahippocampus) functional connectivity data from aphasic patients.Brain regions showing FC differences between patients with aphasia and controls by two-sample t-test (p < 0.05 FDR-corrected and minimum cluster size of 30 voxels). Warm and cold colors indicate regions with increased and decreased FC values in aphasia, respectively. Numbers below the axial slices refer to the z-plane coordinates of the MNI space, respectively. Letters L and R correspond to the left and right sides of the brain, respectively. Further details of these regions are presented in Table 4.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835729&req=5

f4: Abnormalities in the seed-based (right hippocampus/parahippocampus) functional connectivity data from aphasic patients.Brain regions showing FC differences between patients with aphasia and controls by two-sample t-test (p < 0.05 FDR-corrected and minimum cluster size of 30 voxels). Warm and cold colors indicate regions with increased and decreased FC values in aphasia, respectively. Numbers below the axial slices refer to the z-plane coordinates of the MNI space, respectively. Letters L and R correspond to the left and right sides of the brain, respectively. Further details of these regions are presented in Table 4.
Mentions: The contralesional HIP/ParaHip not only show increased ALFF, but it also correlated with construction score on the ABC. Thus, the contralesional HIP/ParaHip was defined as the seed region for subsequent interregional FC analysis. Aphasic patients exhibited increased functional connectivity between the contralesional HIP/ParaHip (seed region) and the contralesional FFG (FDR corrected p < 0.05 and minimum cluster size of 30 voxels). Aphasic patients also showed reduced FC between the contralesional HIP/ParaHip and the ipsilesional middle occipital gyrus, paracentral lobule, postcentral gyrus, and middle/superior temporal pole (FDR corrected p < 0.05 and minimum cluster size of 30 voxels) (Table 4 and Fig. 4).

Bottom Line: In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score.These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity.Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

View Article: PubMed Central - PubMed

Affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

ABSTRACT
Several neuroimaging studies have examined cerebral function in patients who suffer from aphasia, but the mechanism underlying this disorder remains poorly understood. In this study, we examined alterations in the local regional and remote interregional network cerebral functions in aphasia combined with amplitude of low-frequency fluctuations and interregional functional connectivity (FC) using resting-state functional magnetic resonance imaging. A total of 17 post-stroke aphasic patients, all having suffered a stroke in the left hemisphere, as well as 20 age- and sex-matched healthy controls, were enrolled in this study. The aphasic patients showed significantly increased intrinsic regional activity mainly in the contralesional mesial temporal (hippocampus/parahippocampus, [HIP/ParaHIP]) and lateral temporal cortices. In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score. Aphasic patients showed increased remote interregional FC between the contralesional HIP/ParaHIP and fusiform gyrus, but reduced FC in the ipsilesional occipital and parietal cortices. These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity. Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

No MeSH data available.


Related in: MedlinePlus