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Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia.

Yang M, Li J, Li Y, Li R, Pang Y, Yao D, Liao W, Chen H - Sci Rep (2016)

Bottom Line: In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score.These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity.Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

View Article: PubMed Central - PubMed

Affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

ABSTRACT
Several neuroimaging studies have examined cerebral function in patients who suffer from aphasia, but the mechanism underlying this disorder remains poorly understood. In this study, we examined alterations in the local regional and remote interregional network cerebral functions in aphasia combined with amplitude of low-frequency fluctuations and interregional functional connectivity (FC) using resting-state functional magnetic resonance imaging. A total of 17 post-stroke aphasic patients, all having suffered a stroke in the left hemisphere, as well as 20 age- and sex-matched healthy controls, were enrolled in this study. The aphasic patients showed significantly increased intrinsic regional activity mainly in the contralesional mesial temporal (hippocampus/parahippocampus, [HIP/ParaHIP]) and lateral temporal cortices. In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score. Aphasic patients showed increased remote interregional FC between the contralesional HIP/ParaHIP and fusiform gyrus, but reduced FC in the ipsilesional occipital and parietal cortices. These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity. Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

No MeSH data available.


Related in: MedlinePlus

Correlation between ALFF and clinical scores in aphasic patients.ALFF values in the right hippocampus/parahippocampus were negatively correlated with construction scores in the Aphasia Battery of Chinese (r = −0.51, p = 0.03). The solid line and dashed lines represent the best-fit line and 95% confidence interval of Pearson correlation, respectively.
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f3: Correlation between ALFF and clinical scores in aphasic patients.ALFF values in the right hippocampus/parahippocampus were negatively correlated with construction scores in the Aphasia Battery of Chinese (r = −0.51, p = 0.03). The solid line and dashed lines represent the best-fit line and 95% confidence interval of Pearson correlation, respectively.

Mentions: The linear Pearson correlation between altered regional ALFF values and clinical characteristics in aphasic patients was calculated. ALFF in the contralesional HIP/ParaHip was negatively correlated with construction score on the ABC (r = −0.51, p = 0.03) (Fig. 3). We found no other significant correlations between the ALFF values in other brain regions and clinical characteristics.


Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia.

Yang M, Li J, Li Y, Li R, Pang Y, Yao D, Liao W, Chen H - Sci Rep (2016)

Correlation between ALFF and clinical scores in aphasic patients.ALFF values in the right hippocampus/parahippocampus were negatively correlated with construction scores in the Aphasia Battery of Chinese (r = −0.51, p = 0.03). The solid line and dashed lines represent the best-fit line and 95% confidence interval of Pearson correlation, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835729&req=5

f3: Correlation between ALFF and clinical scores in aphasic patients.ALFF values in the right hippocampus/parahippocampus were negatively correlated with construction scores in the Aphasia Battery of Chinese (r = −0.51, p = 0.03). The solid line and dashed lines represent the best-fit line and 95% confidence interval of Pearson correlation, respectively.
Mentions: The linear Pearson correlation between altered regional ALFF values and clinical characteristics in aphasic patients was calculated. ALFF in the contralesional HIP/ParaHip was negatively correlated with construction score on the ABC (r = −0.51, p = 0.03) (Fig. 3). We found no other significant correlations between the ALFF values in other brain regions and clinical characteristics.

Bottom Line: In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score.These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity.Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

View Article: PubMed Central - PubMed

Affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

ABSTRACT
Several neuroimaging studies have examined cerebral function in patients who suffer from aphasia, but the mechanism underlying this disorder remains poorly understood. In this study, we examined alterations in the local regional and remote interregional network cerebral functions in aphasia combined with amplitude of low-frequency fluctuations and interregional functional connectivity (FC) using resting-state functional magnetic resonance imaging. A total of 17 post-stroke aphasic patients, all having suffered a stroke in the left hemisphere, as well as 20 age- and sex-matched healthy controls, were enrolled in this study. The aphasic patients showed significantly increased intrinsic regional activity mainly in the contralesional mesial temporal (hippocampus/parahippocampus, [HIP/ParaHIP]) and lateral temporal cortices. In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score. Aphasic patients showed increased remote interregional FC between the contralesional HIP/ParaHIP and fusiform gyrus, but reduced FC in the ipsilesional occipital and parietal cortices. These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity. Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

No MeSH data available.


Related in: MedlinePlus