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Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia.

Yang M, Li J, Li Y, Li R, Pang Y, Yao D, Liao W, Chen H - Sci Rep (2016)

Bottom Line: In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score.These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity.Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

View Article: PubMed Central - PubMed

Affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

ABSTRACT
Several neuroimaging studies have examined cerebral function in patients who suffer from aphasia, but the mechanism underlying this disorder remains poorly understood. In this study, we examined alterations in the local regional and remote interregional network cerebral functions in aphasia combined with amplitude of low-frequency fluctuations and interregional functional connectivity (FC) using resting-state functional magnetic resonance imaging. A total of 17 post-stroke aphasic patients, all having suffered a stroke in the left hemisphere, as well as 20 age- and sex-matched healthy controls, were enrolled in this study. The aphasic patients showed significantly increased intrinsic regional activity mainly in the contralesional mesial temporal (hippocampus/parahippocampus, [HIP/ParaHIP]) and lateral temporal cortices. In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score. Aphasic patients showed increased remote interregional FC between the contralesional HIP/ParaHIP and fusiform gyrus, but reduced FC in the ipsilesional occipital and parietal cortices. These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity. Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

No MeSH data available.


Related in: MedlinePlus

Brain regions showing significant differences in ALFF between aphasic patients and controls.All comparisons were performed using a two-sample t-test (pā€‰<ā€‰0.05 FDR-corrected and minimum cluster size of 30 voxels). (A) Warm colors indicate regions with increased ALFF values in aphasia. (B) Cold colors indicate regions with decreased ALFF values in aphasia. Numbers below each sagittal, coronal and axial slice refer to the x-, y-, and z-plane coordinates of the MNI space, respectively. Letters L and R correspond to the left and right sides of the brain, respectively. Further details of these regions are presented in Table 3.
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f2: Brain regions showing significant differences in ALFF between aphasic patients and controls.All comparisons were performed using a two-sample t-test (pā€‰<ā€‰0.05 FDR-corrected and minimum cluster size of 30 voxels). (A) Warm colors indicate regions with increased ALFF values in aphasia. (B) Cold colors indicate regions with decreased ALFF values in aphasia. Numbers below each sagittal, coronal and axial slice refer to the x-, y-, and z-plane coordinates of the MNI space, respectively. Letters L and R correspond to the left and right sides of the brain, respectively. Further details of these regions are presented in Table 3.

Mentions: Compared with HCs, post-stroke aphasic patients showed significantly increased ALFF in the contralesional hemisphere, namely, in the hippocampus/parahippocampus (HIP/ParaHip), fusiform gyrus (FFG), inferior temporal gyrus, middle temporal gyrus, and middle temporal pole (false discovery rate (FDR) corrected pā€‰<ā€‰0.05 and minimum cluster size of 30 voxels). Conversely, aphasic patients indicated significantly reduced ALFF in the ipsilesional hemisphere, particularly, at the superior frontal gyrus, the bilateral precentral gyrus, lingual gyrus, supplementary motor area, and anterior cingulate cortex (FDR corrected pā€‰<ā€‰0.05 and minimum cluster size of 30 voxels) (Table 3 and Fig. 2).


Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia.

Yang M, Li J, Li Y, Li R, Pang Y, Yao D, Liao W, Chen H - Sci Rep (2016)

Brain regions showing significant differences in ALFF between aphasic patients and controls.All comparisons were performed using a two-sample t-test (pā€‰<ā€‰0.05 FDR-corrected and minimum cluster size of 30 voxels). (A) Warm colors indicate regions with increased ALFF values in aphasia. (B) Cold colors indicate regions with decreased ALFF values in aphasia. Numbers below each sagittal, coronal and axial slice refer to the x-, y-, and z-plane coordinates of the MNI space, respectively. Letters L and R correspond to the left and right sides of the brain, respectively. Further details of these regions are presented in Table 3.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835729&req=5

f2: Brain regions showing significant differences in ALFF between aphasic patients and controls.All comparisons were performed using a two-sample t-test (pā€‰<ā€‰0.05 FDR-corrected and minimum cluster size of 30 voxels). (A) Warm colors indicate regions with increased ALFF values in aphasia. (B) Cold colors indicate regions with decreased ALFF values in aphasia. Numbers below each sagittal, coronal and axial slice refer to the x-, y-, and z-plane coordinates of the MNI space, respectively. Letters L and R correspond to the left and right sides of the brain, respectively. Further details of these regions are presented in Table 3.
Mentions: Compared with HCs, post-stroke aphasic patients showed significantly increased ALFF in the contralesional hemisphere, namely, in the hippocampus/parahippocampus (HIP/ParaHip), fusiform gyrus (FFG), inferior temporal gyrus, middle temporal gyrus, and middle temporal pole (false discovery rate (FDR) corrected pā€‰<ā€‰0.05 and minimum cluster size of 30 voxels). Conversely, aphasic patients indicated significantly reduced ALFF in the ipsilesional hemisphere, particularly, at the superior frontal gyrus, the bilateral precentral gyrus, lingual gyrus, supplementary motor area, and anterior cingulate cortex (FDR corrected pā€‰<ā€‰0.05 and minimum cluster size of 30 voxels) (Table 3 and Fig. 2).

Bottom Line: In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score.These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity.Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

View Article: PubMed Central - PubMed

Affiliation: Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

ABSTRACT
Several neuroimaging studies have examined cerebral function in patients who suffer from aphasia, but the mechanism underlying this disorder remains poorly understood. In this study, we examined alterations in the local regional and remote interregional network cerebral functions in aphasia combined with amplitude of low-frequency fluctuations and interregional functional connectivity (FC) using resting-state functional magnetic resonance imaging. A total of 17 post-stroke aphasic patients, all having suffered a stroke in the left hemisphere, as well as 20 age- and sex-matched healthy controls, were enrolled in this study. The aphasic patients showed significantly increased intrinsic regional activity mainly in the contralesional mesial temporal (hippocampus/parahippocampus, [HIP/ParaHIP]) and lateral temporal cortices. In addition, intrinsic regional activity in the contralesional HIP/ParaHIP was negatively correlated with construction score. Aphasic patients showed increased remote interregional FC between the contralesional HIP/ParaHIP and fusiform gyrus, but reduced FC in the ipsilesional occipital and parietal cortices. These findings suggested that the intrinsic regional brain dysfunctions in aphasia were related to interregional functional connectivity. Changes in the intrinsic regional brain activity and associated remote functional connectivity pattern would provide valuable information to enhance the understanding of the pathophysiological mechanisms of aphasia.

No MeSH data available.


Related in: MedlinePlus