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Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus

Cumulative release of CM from various formulations of P407/CMCs composite hydrogel ((a) release percentage; (b) detected concentration of GA). The experiments were performed in triplicate by the dialysis method.
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f7: Cumulative release of CM from various formulations of P407/CMCs composite hydrogel ((a) release percentage; (b) detected concentration of GA). The experiments were performed in triplicate by the dialysis method.

Mentions: Figure 7 illustrates the profile of in vitro release of CM from various formulations of P407/CMCs composite hydrogel. It is clearly observed that over 95% of CM was released from PC200 within 48 h, whereas PC202 and PC204 released less than 90% of CM during the period. The three formulations had a steady release rate over 24 h, after which the release rate gradually decreased. Moreover, PC200 had the highest release rate, while PC204 exhibited the lowest rate, indicating that the addition of CMCs reduced the rate of release of the drug. This was primarily because the presence of CMCs raised the viscosity in the system and the high viscosity served to retard the diffusion of the drug. Additionally, the dialysis method we adopted in the present study allowed permeation of water molecules across the dialysis membrane. Considerable structural changes thus occurred, including alteration of shape and size distribution of the pores, due to progressive swelling of hydrophilic composite hydrogels, resulting in an increase in the tortuosity during the diffusional release of the drug37.


Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Cumulative release of CM from various formulations of P407/CMCs composite hydrogel ((a) release percentage; (b) detected concentration of GA). The experiments were performed in triplicate by the dialysis method.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835724&req=5

f7: Cumulative release of CM from various formulations of P407/CMCs composite hydrogel ((a) release percentage; (b) detected concentration of GA). The experiments were performed in triplicate by the dialysis method.
Mentions: Figure 7 illustrates the profile of in vitro release of CM from various formulations of P407/CMCs composite hydrogel. It is clearly observed that over 95% of CM was released from PC200 within 48 h, whereas PC202 and PC204 released less than 90% of CM during the period. The three formulations had a steady release rate over 24 h, after which the release rate gradually decreased. Moreover, PC200 had the highest release rate, while PC204 exhibited the lowest rate, indicating that the addition of CMCs reduced the rate of release of the drug. This was primarily because the presence of CMCs raised the viscosity in the system and the high viscosity served to retard the diffusion of the drug. Additionally, the dialysis method we adopted in the present study allowed permeation of water molecules across the dialysis membrane. Considerable structural changes thus occurred, including alteration of shape and size distribution of the pores, due to progressive swelling of hydrophilic composite hydrogels, resulting in an increase in the tortuosity during the diffusional release of the drug37.

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus