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Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus

Storage modulus and complex viscosity versus temperature curves of various formulations of P407/CMCs hydrogel.
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f5: Storage modulus and complex viscosity versus temperature curves of various formulations of P407/CMCs hydrogel.

Mentions: As seen in Fig. 5, the rheological characteristics of P407/CMCs binary composite hydrogel are temperature-dependent. With increasing temperature, various hydrogel formulations exhibit a consistent alteration in the complex viscosity and storage modulus, both of which increase sharply at the gelation temperature. The highest storage modulus and complex viscosity were seen in PC204. Analogous to phase transition analysis, rheological analysis also shows that the presence of CMCs slightly lowers the SGTT but enhances the storage modulus and complex viscosity due to intermicellar interactions and an increase in the effective length of the hydrophilic chain. Considering the abundant porous structure of composite hydrogel formulations with the addition of CMCs, PC204 was the optimal specimen for further experiments.


Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Storage modulus and complex viscosity versus temperature curves of various formulations of P407/CMCs hydrogel.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835724&req=5

f5: Storage modulus and complex viscosity versus temperature curves of various formulations of P407/CMCs hydrogel.
Mentions: As seen in Fig. 5, the rheological characteristics of P407/CMCs binary composite hydrogel are temperature-dependent. With increasing temperature, various hydrogel formulations exhibit a consistent alteration in the complex viscosity and storage modulus, both of which increase sharply at the gelation temperature. The highest storage modulus and complex viscosity were seen in PC204. Analogous to phase transition analysis, rheological analysis also shows that the presence of CMCs slightly lowers the SGTT but enhances the storage modulus and complex viscosity due to intermicellar interactions and an increase in the effective length of the hydrophilic chain. Considering the abundant porous structure of composite hydrogel formulations with the addition of CMCs, PC204 was the optimal specimen for further experiments.

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus