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Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus

SEM images of PC200 (a) (3000x), PC202 (b) (3000x) and PC204 (c) (3000x) hydrogel.
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f4: SEM images of PC200 (a) (3000x), PC202 (b) (3000x) and PC204 (c) (3000x) hydrogel.

Mentions: FE-SEM morphology of varying formulations of lyophilized P407/CMCs composite hydrogel is depicted in Fig. 4. As expected, surface morphology of P407 was altered with the addition of bioadhesive polymer (CMCs), i.e., an apparent increase in the porous structure (Fig. 4b,c). It is evident that the porosity is positively correlated with concentration of CMCs, i.e., high concentration results in high porosity. This porous structure is expected to afford excellent drug-loading capacity and controlled release property to the composite hydrogel.


Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

SEM images of PC200 (a) (3000x), PC202 (b) (3000x) and PC204 (c) (3000x) hydrogel.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835724&req=5

f4: SEM images of PC200 (a) (3000x), PC202 (b) (3000x) and PC204 (c) (3000x) hydrogel.
Mentions: FE-SEM morphology of varying formulations of lyophilized P407/CMCs composite hydrogel is depicted in Fig. 4. As expected, surface morphology of P407 was altered with the addition of bioadhesive polymer (CMCs), i.e., an apparent increase in the porous structure (Fig. 4b,c). It is evident that the porosity is positively correlated with concentration of CMCs, i.e., high concentration results in high porosity. This porous structure is expected to afford excellent drug-loading capacity and controlled release property to the composite hydrogel.

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus