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Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus

SGTT (a) and gelation time (b) of P407/CMCs hydrogels as a function of the temperature measured by “tube inversion method” (n = 5, *p < 0.05).
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f3: SGTT (a) and gelation time (b) of P407/CMCs hydrogels as a function of the temperature measured by “tube inversion method” (n = 5, *p < 0.05).

Mentions: Phase transition properties of composite hydrogel formulations were measured using tube inversion by observing the flowability of P407/CMCs solution. As shown in Fig. 2, the composite hydrogel of P407/CMCs exhibited remarkable reversible sol-gel transition properties. The gelation mechanism can be interpreted by dehydration of PO block and intermicellar interaction (Fig. 2e)36. The presence of hydrophilic CMCs can strengthen the hydrophilic chain of the system, thereby reducing the SGTT (Fig. 3) and enhancing the storage modulus of P407/CMCs composite hydrogel. Figure 3 clearly shows that the SGTT slightly decreased on addition of CMCs and accordingly, the gelation time saw a noticeable increase. As expected, there was a marked decline in the gelation time as the temperature increased. Likewise, compared to blank hydrogel, the gelation time of CM loaded hydrogel also dropped appreciably. However, CM was not found to significantly alter the SGTT (Fig. 3a).


Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

SGTT (a) and gelation time (b) of P407/CMCs hydrogels as a function of the temperature measured by “tube inversion method” (n = 5, *p < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835724&req=5

f3: SGTT (a) and gelation time (b) of P407/CMCs hydrogels as a function of the temperature measured by “tube inversion method” (n = 5, *p < 0.05).
Mentions: Phase transition properties of composite hydrogel formulations were measured using tube inversion by observing the flowability of P407/CMCs solution. As shown in Fig. 2, the composite hydrogel of P407/CMCs exhibited remarkable reversible sol-gel transition properties. The gelation mechanism can be interpreted by dehydration of PO block and intermicellar interaction (Fig. 2e)36. The presence of hydrophilic CMCs can strengthen the hydrophilic chain of the system, thereby reducing the SGTT (Fig. 3) and enhancing the storage modulus of P407/CMCs composite hydrogel. Figure 3 clearly shows that the SGTT slightly decreased on addition of CMCs and accordingly, the gelation time saw a noticeable increase. As expected, there was a marked decline in the gelation time as the temperature increased. Likewise, compared to blank hydrogel, the gelation time of CM loaded hydrogel also dropped appreciably. However, CM was not found to significantly alter the SGTT (Fig. 3a).

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus