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Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus

Micrographs to show sol-gel transition of P407/CMCs composite hydrogel ((a,b) representing blank hydrogel P200; (c,d) representing drug loaded hydrogel PC204); the sol-gel transition is elucidated by schemati cdiagram (e); and the FE-SEM cross-section image (f) (3000x) to illustrate the porous structure caused by ordered spherical micelles.
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f2: Micrographs to show sol-gel transition of P407/CMCs composite hydrogel ((a,b) representing blank hydrogel P200; (c,d) representing drug loaded hydrogel PC204); the sol-gel transition is elucidated by schemati cdiagram (e); and the FE-SEM cross-section image (f) (3000x) to illustrate the porous structure caused by ordered spherical micelles.

Mentions: Hydrogel offers an ideal solution for developing this preconceived transdermal drug delivery system with dual-functions. Hydrogels are hydrophilic three-dimensional polymeric networks capable of absorbing a large amount of water or biological fluids28. The high moisture content renders hydrogels compatible with most living tissues and thus facilitates widespread application in biomedical and pharmaceutical areas2930. Thermo-sensitive hydrogel exhibits a free-flowing sol at low temperatures but becomes a gel at body temperature, which facilitates administration and accessibility when applied in drug delivery systems3132. Poloxamer 407 (Pluronic F127) is one of the most typical thermosensitive polymers and has been approved by the FDA. Poloxamer 407 can self-assemble into micellar structures and form hydrogels under certain conditions (Fig. 2e). The micellization results from the dehydration of hydrophobic PO blocks and the resultant micelles are spherical with a dehydrated polyPO core and an outer shell of hydrated swollen polyEO chains3334. A high drug loading can therefore be achieved simply by incorporating hydrophilic drugs into the micellar structures. Also, bioadhesive polymers such as cellulose derivatives are normally added to enhance the poor bioadhesive property of poloxamer-based hydrogels35. This, typically, not only contributes to increase of bioadhesive property of the system, but also improves the surface morphology structure, i.e., porosity, which is demonstrated visually in the present study.


Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Micrographs to show sol-gel transition of P407/CMCs composite hydrogel ((a,b) representing blank hydrogel P200; (c,d) representing drug loaded hydrogel PC204); the sol-gel transition is elucidated by schemati cdiagram (e); and the FE-SEM cross-section image (f) (3000x) to illustrate the porous structure caused by ordered spherical micelles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835724&req=5

f2: Micrographs to show sol-gel transition of P407/CMCs composite hydrogel ((a,b) representing blank hydrogel P200; (c,d) representing drug loaded hydrogel PC204); the sol-gel transition is elucidated by schemati cdiagram (e); and the FE-SEM cross-section image (f) (3000x) to illustrate the porous structure caused by ordered spherical micelles.
Mentions: Hydrogel offers an ideal solution for developing this preconceived transdermal drug delivery system with dual-functions. Hydrogels are hydrophilic three-dimensional polymeric networks capable of absorbing a large amount of water or biological fluids28. The high moisture content renders hydrogels compatible with most living tissues and thus facilitates widespread application in biomedical and pharmaceutical areas2930. Thermo-sensitive hydrogel exhibits a free-flowing sol at low temperatures but becomes a gel at body temperature, which facilitates administration and accessibility when applied in drug delivery systems3132. Poloxamer 407 (Pluronic F127) is one of the most typical thermosensitive polymers and has been approved by the FDA. Poloxamer 407 can self-assemble into micellar structures and form hydrogels under certain conditions (Fig. 2e). The micellization results from the dehydration of hydrophobic PO blocks and the resultant micelles are spherical with a dehydrated polyPO core and an outer shell of hydrated swollen polyEO chains3334. A high drug loading can therefore be achieved simply by incorporating hydrophilic drugs into the micellar structures. Also, bioadhesive polymers such as cellulose derivatives are normally added to enhance the poor bioadhesive property of poloxamer-based hydrogels35. This, typically, not only contributes to increase of bioadhesive property of the system, but also improves the surface morphology structure, i.e., porosity, which is demonstrated visually in the present study.

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus