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Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of hydrogel functionalized fabric with dual-functions; (i) to coat drug-loading hydrogel onto the fabric; (ii) to apply the hydrogel coated fabric to the skin of a patient; and (iii) to show how the coated fabric works with moisture and drug diffusion across the skin.
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f1: Schematic diagram of hydrogel functionalized fabric with dual-functions; (i) to coat drug-loading hydrogel onto the fabric; (ii) to apply the hydrogel coated fabric to the skin of a patient; and (iii) to show how the coated fabric works with moisture and drug diffusion across the skin.

Mentions: The treatment of atopic dermatitis (AD) has been perplexing clinicians and practitioners for decades12345. Conventional mainstream medication always involves the use of topical or systematic corticosteroids, which may cause serious adverse effects such as striae, hypertension or even atrophy; the use of corticosteroids is highly not recommended, especially for young children with AD678. A wide variety of complementary or alternative therapies, e.g., acupuncture, homeopathy, probiotics, autologous blood injection, massage therapy and herbal preparations, etc., have therefore received considerable attention91011, among which textiles functionalized with physicochemical means or nanotechnology is the most typical adjuvant therapy121314. The development of conventional functionalized textiles is proposed on the basis of reduction or elimination of S. aureus colonization associated with AD15. Silver nanoparticles have thus been intensively investigated for the development of functionalized textiles due to its excellent antibacterial property16. It has been reported that such textiles significantly inhibit S. aureus growth and are viewed as a promising candidate for AD treatment1718. Additionally, zinc oxide nanoparticles and some naturally occurring organic compounds, such as citric acid and borage oil, have also been reported in the functionalization of textiles192021. However, an inevitable problem for these functional textiles is that they cannot rehydrate the skin and may exacerbate the xerodermia of AD patients, even though they showed therapeutic effects to some extent22. For this purpose, wet-wrap dressing is thus considered a satisfactory alternative to functionalized textiles for moisturizing the skin and controlling the transepidermal moisture loss2324. Unfortunately, wet-wrap dressing mainly serves as a moisture reservoir and its prolonged use normally leads to an uncomfortable feeling25. Consequently, the therapeutic effect of wet-wrap dressing is apparently limited and can be negligible unless it is used in combination with some medications2627. Inspired by this, we are prompted to develop a transdermal drug delivery system with dual-functions, i.e., moisture and drug supply (Fig. 1), which may be used for development of functionalized textiles which can release the drug in a controlled manner.


Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment.

Wang W, Wat E, Hui PC, Chan B, Ng FS, Kan CW, Wang X, Hu H, Wong EC, Lau CB, Leung PC - Sci Rep (2016)

Schematic diagram of hydrogel functionalized fabric with dual-functions; (i) to coat drug-loading hydrogel onto the fabric; (ii) to apply the hydrogel coated fabric to the skin of a patient; and (iii) to show how the coated fabric works with moisture and drug diffusion across the skin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835724&req=5

f1: Schematic diagram of hydrogel functionalized fabric with dual-functions; (i) to coat drug-loading hydrogel onto the fabric; (ii) to apply the hydrogel coated fabric to the skin of a patient; and (iii) to show how the coated fabric works with moisture and drug diffusion across the skin.
Mentions: The treatment of atopic dermatitis (AD) has been perplexing clinicians and practitioners for decades12345. Conventional mainstream medication always involves the use of topical or systematic corticosteroids, which may cause serious adverse effects such as striae, hypertension or even atrophy; the use of corticosteroids is highly not recommended, especially for young children with AD678. A wide variety of complementary or alternative therapies, e.g., acupuncture, homeopathy, probiotics, autologous blood injection, massage therapy and herbal preparations, etc., have therefore received considerable attention91011, among which textiles functionalized with physicochemical means or nanotechnology is the most typical adjuvant therapy121314. The development of conventional functionalized textiles is proposed on the basis of reduction or elimination of S. aureus colonization associated with AD15. Silver nanoparticles have thus been intensively investigated for the development of functionalized textiles due to its excellent antibacterial property16. It has been reported that such textiles significantly inhibit S. aureus growth and are viewed as a promising candidate for AD treatment1718. Additionally, zinc oxide nanoparticles and some naturally occurring organic compounds, such as citric acid and borage oil, have also been reported in the functionalization of textiles192021. However, an inevitable problem for these functional textiles is that they cannot rehydrate the skin and may exacerbate the xerodermia of AD patients, even though they showed therapeutic effects to some extent22. For this purpose, wet-wrap dressing is thus considered a satisfactory alternative to functionalized textiles for moisturizing the skin and controlling the transepidermal moisture loss2324. Unfortunately, wet-wrap dressing mainly serves as a moisture reservoir and its prolonged use normally leads to an uncomfortable feeling25. Consequently, the therapeutic effect of wet-wrap dressing is apparently limited and can be negligible unless it is used in combination with some medications2627. Inspired by this, we are prompted to develop a transdermal drug delivery system with dual-functions, i.e., moisture and drug supply (Fig. 1), which may be used for development of functionalized textiles which can release the drug in a controlled manner.

Bottom Line: The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession.It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading.The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test.

View Article: PubMed Central - PubMed

Affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

ABSTRACT
The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary therapies have been introduced, they fail to combine the skin moisturizing and drug supply for AD patients. This study reports the development of a thermo-sensitive Poloxamer 407/Carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel formulation with twin functions of moisture and drug supply for AD treatment. It was found that the presence of CMCs can appreciably improve the physical properties of P407 hydrogel, which makes it more suitable for tailored drug loading. The fabricated P407/CMCs composite hydrogel was also characterized in terms of surface morphology by field emission scanning electron microscopy (FE-SEM), rheological properties by a rheometer, release profile in vitro by dialysis method and cytotoxicity test. More importantly, the findings from transdermal drug delivery behavior revealed that P407/CMCs showed desirable percutaneous performance. Additionally, analysis of cytotoxicity test suggested that P407/CMCs composite hydrogel is a high-security therapy for clinical trials and thus exhibits a promising way to treat AD with skin moisturizing and medication.

No MeSH data available.


Related in: MedlinePlus