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Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots.

Chusyd DE, Wang D, Huffman DM, Nagy TR - Front Nutr (2016)

Bottom Line: Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging.While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT.Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition Science, University of Alabama at Birmingham , Birmingham, AL , USA.

ABSTRACT
The objective of this review was to compare and contrast the physiological and metabolic profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat distribution and its metabolic consequences have received extensive attention, but much of what has been tested in translational research has relied heavily on rodents. Unfortunately, the validity of using rodent fat pads as a model of human adiposity has received less attention. There is a surprisingly lack of studies demonstrating an analogous relationship between rodent and human adiposity on obesity-related comorbidities. Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging. While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT. Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

No MeSH data available.


Related in: MedlinePlus

Distribution of fat pads in the mouse. The fat is composed of two subcutaneous pads and several visceral pads. The main white adipose tissue (WAT) pads are the inguinal and epididymal, with the latter being the most frequent dissected pad. Brown adipose tissue (BAT) is distributed throughout the fat pads with the main BAT depot in the interscapular region (18).
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Figure 2: Distribution of fat pads in the mouse. The fat is composed of two subcutaneous pads and several visceral pads. The main white adipose tissue (WAT) pads are the inguinal and epididymal, with the latter being the most frequent dissected pad. Brown adipose tissue (BAT) is distributed throughout the fat pads with the main BAT depot in the interscapular region (18).

Mentions: Like humans, adipose tissue in rodents is a multi-depot organ (Figure 2), but unlike humans, which have two main subcutaneous depots located in the abdominal and gluteofemoral region, rodents have two main subcutaneous pads located anteriorly and posteriorly. The anterior pad is located between the scapulae, descending from the neck to the axillae (17), while, the posterior pad, or inguinal fat pad, spreads from the dorsolumbar region to the gluteal region. The inguinal fat pad is comparable in terms of location to the large gluteofemoral subcutaneous depot in humans. Additionally, rodent SAT is separated from dermal adipose tissue by a smooth muscle layer, whereas, in humans, the SAT is continuous with dermal adipose tissue (17). Furthermore, there has been no evidence to our knowledge of multiple subcutaneous layers in rodents, such as is the case in humans.


Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots.

Chusyd DE, Wang D, Huffman DM, Nagy TR - Front Nutr (2016)

Distribution of fat pads in the mouse. The fat is composed of two subcutaneous pads and several visceral pads. The main white adipose tissue (WAT) pads are the inguinal and epididymal, with the latter being the most frequent dissected pad. Brown adipose tissue (BAT) is distributed throughout the fat pads with the main BAT depot in the interscapular region (18).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835715&req=5

Figure 2: Distribution of fat pads in the mouse. The fat is composed of two subcutaneous pads and several visceral pads. The main white adipose tissue (WAT) pads are the inguinal and epididymal, with the latter being the most frequent dissected pad. Brown adipose tissue (BAT) is distributed throughout the fat pads with the main BAT depot in the interscapular region (18).
Mentions: Like humans, adipose tissue in rodents is a multi-depot organ (Figure 2), but unlike humans, which have two main subcutaneous depots located in the abdominal and gluteofemoral region, rodents have two main subcutaneous pads located anteriorly and posteriorly. The anterior pad is located between the scapulae, descending from the neck to the axillae (17), while, the posterior pad, or inguinal fat pad, spreads from the dorsolumbar region to the gluteal region. The inguinal fat pad is comparable in terms of location to the large gluteofemoral subcutaneous depot in humans. Additionally, rodent SAT is separated from dermal adipose tissue by a smooth muscle layer, whereas, in humans, the SAT is continuous with dermal adipose tissue (17). Furthermore, there has been no evidence to our knowledge of multiple subcutaneous layers in rodents, such as is the case in humans.

Bottom Line: Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging.While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT.Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition Science, University of Alabama at Birmingham , Birmingham, AL , USA.

ABSTRACT
The objective of this review was to compare and contrast the physiological and metabolic profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat distribution and its metabolic consequences have received extensive attention, but much of what has been tested in translational research has relied heavily on rodents. Unfortunately, the validity of using rodent fat pads as a model of human adiposity has received less attention. There is a surprisingly lack of studies demonstrating an analogous relationship between rodent and human adiposity on obesity-related comorbidities. Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging. While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT. Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

No MeSH data available.


Related in: MedlinePlus