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Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots.

Chusyd DE, Wang D, Huffman DM, Nagy TR - Front Nutr (2016)

Bottom Line: Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging.While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT.Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition Science, University of Alabama at Birmingham , Birmingham, AL , USA.

ABSTRACT
The objective of this review was to compare and contrast the physiological and metabolic profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat distribution and its metabolic consequences have received extensive attention, but much of what has been tested in translational research has relied heavily on rodents. Unfortunately, the validity of using rodent fat pads as a model of human adiposity has received less attention. There is a surprisingly lack of studies demonstrating an analogous relationship between rodent and human adiposity on obesity-related comorbidities. Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging. While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT. Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

No MeSH data available.


Related in: MedlinePlus

(A) Distribution of fat depots in the human. The white adipose tissue (WAT) is found in subcutaneous adipose tissue (SAT) abdominally (a), gluteofemorally (g), and intramuscularly (h). WAT is also found in the visceral adipose tissue (VAT). The visceral depots are omental (b), mesenteric (c), retroperitoneal (d), gonadal (e), and pericardial (f). Brown adipose tissue is found supraclavicularly (i) and in the subscapular region (j). (B) Those fat depots linked to increased risk of developing obesity-related morbidities and mortality are colored in red (13).
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Figure 1: (A) Distribution of fat depots in the human. The white adipose tissue (WAT) is found in subcutaneous adipose tissue (SAT) abdominally (a), gluteofemorally (g), and intramuscularly (h). WAT is also found in the visceral adipose tissue (VAT). The visceral depots are omental (b), mesenteric (c), retroperitoneal (d), gonadal (e), and pericardial (f). Brown adipose tissue is found supraclavicularly (i) and in the subscapular region (j). (B) Those fat depots linked to increased risk of developing obesity-related morbidities and mortality are colored in red (13).

Mentions: There are three main regional human anatomical fat depots: intra-abdominal, upper-body/abdominal subcutaneous, and lower body subcutaneous (Figure 1A) (12). Intra-abdominal refers to visceral adipose tissue (VAT), which surrounds the inner organs (13). VAT can further be divided into omental, mesenteric, retroperitoneal, gonadal, and pericardial. The upper-body subcutaneous adipose tissue (SAT) can be categorized depending on if it is situated superficial or deep to the fascia superficialis. The adipose tissue below the fascia is the deep subcutaneous adipose tissue (DSAT) compartment, whereas adipose tissue located superficially to this fascia is the superficial subcutaneous adipose tissue (SSAT) compartment (14, 15). Though SAT is distributed throughout the human body, the main depots are in the abdomen, buttocks, and thighs (16). The buttocks and thighs make up the lower body SAT and are termed the gluteofemoral depot (12, 13).


Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots.

Chusyd DE, Wang D, Huffman DM, Nagy TR - Front Nutr (2016)

(A) Distribution of fat depots in the human. The white adipose tissue (WAT) is found in subcutaneous adipose tissue (SAT) abdominally (a), gluteofemorally (g), and intramuscularly (h). WAT is also found in the visceral adipose tissue (VAT). The visceral depots are omental (b), mesenteric (c), retroperitoneal (d), gonadal (e), and pericardial (f). Brown adipose tissue is found supraclavicularly (i) and in the subscapular region (j). (B) Those fat depots linked to increased risk of developing obesity-related morbidities and mortality are colored in red (13).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835715&req=5

Figure 1: (A) Distribution of fat depots in the human. The white adipose tissue (WAT) is found in subcutaneous adipose tissue (SAT) abdominally (a), gluteofemorally (g), and intramuscularly (h). WAT is also found in the visceral adipose tissue (VAT). The visceral depots are omental (b), mesenteric (c), retroperitoneal (d), gonadal (e), and pericardial (f). Brown adipose tissue is found supraclavicularly (i) and in the subscapular region (j). (B) Those fat depots linked to increased risk of developing obesity-related morbidities and mortality are colored in red (13).
Mentions: There are three main regional human anatomical fat depots: intra-abdominal, upper-body/abdominal subcutaneous, and lower body subcutaneous (Figure 1A) (12). Intra-abdominal refers to visceral adipose tissue (VAT), which surrounds the inner organs (13). VAT can further be divided into omental, mesenteric, retroperitoneal, gonadal, and pericardial. The upper-body subcutaneous adipose tissue (SAT) can be categorized depending on if it is situated superficial or deep to the fascia superficialis. The adipose tissue below the fascia is the deep subcutaneous adipose tissue (DSAT) compartment, whereas adipose tissue located superficially to this fascia is the superficial subcutaneous adipose tissue (SSAT) compartment (14, 15). Though SAT is distributed throughout the human body, the main depots are in the abdomen, buttocks, and thighs (16). The buttocks and thighs make up the lower body SAT and are termed the gluteofemoral depot (12, 13).

Bottom Line: Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging.While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT.Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition Science, University of Alabama at Birmingham , Birmingham, AL , USA.

ABSTRACT
The objective of this review was to compare and contrast the physiological and metabolic profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat distribution and its metabolic consequences have received extensive attention, but much of what has been tested in translational research has relied heavily on rodents. Unfortunately, the validity of using rodent fat pads as a model of human adiposity has received less attention. There is a surprisingly lack of studies demonstrating an analogous relationship between rodent and human adiposity on obesity-related comorbidities. Therefore, we aimed to compare known similarities and disparities in terms of white adipose tissue (WAT) development and distribution, sexual dimorphism, weight loss, adipokine secretion, and aging. While the literature supports the notion that many similarities exist between rodents and humans, notable differences emerge related to fat deposition and function of WAT. Thus, further research is warranted to more carefully define the strengths and limitations of rodent WAT as a model for humans, with a particular emphasis on comparable fat depots, such as mesenteric fat.

No MeSH data available.


Related in: MedlinePlus