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Changes in seroprevalence of hepatitis B surface antigen and epidemiologic characteristics in the Republic of Korea, 1998-2013.

Lee H, Lee H, Cho Y, Oh K, Ki M - Epidemiol Health (2015)

Bottom Line: HBsAg-positive people showed high values from two liver function tests, including glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and the prevalence rates of liver cirrhosis and liver cancer were also significantly high.While HBsAg seropositive rates tended to decline after 1998, there have been no significant changes over the most recent five years.In addition, it may be necessary to encourage HBsAg-positive people to follow healthier life-styles in order to prevent further progression of hepatitis B to liver cirrhosis and liver cancer.

View Article: PubMed Central - PubMed

Affiliation: Division of Health and Nutrition Survey, Centers for Disease Control and Prevention, Cheongju, Korea.

ABSTRACT

Objectives: This study investigated changes in hepatitis B seroprevalence from 1998 to 2013, and to identify differences in epidemiologic characteristics between hepatitis B surface antigen (HBsAg)-positive and HBsAg-negative people.

Methods: HBsAg seropositive rates were compared by year, sex, and age using the blood test data from the periods I to VI (1998-2013) of the Korea National Health and Nutrition Examination Survey. Interviews and self-administered surveys were conducted to collect data on health behavior, quality of life, comorbidities, and health care utilization.

Results: HBsAg seropositive rates in the Republic of Korea decreased from 4.6% in 1998 to 2.9% in 2008, and then remained the same for the next five years. While seropositive rates by age were the highest at 35 to 39 years of age in 1998, it peaked at 50 to 54 years of age in 2013. HBsAg-positive people showed high values from two liver function tests, including glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and the prevalence rates of liver cirrhosis and liver cancer were also significantly high. Indices for health behavior and quality of life showed no significant differences between HBsAg-positive and HBsAg-negative people.

Conclusions: While HBsAg seropositive rates tended to decline after 1998, there have been no significant changes over the most recent five years. We should focus on treatment of existing hepatitis B patients along with immunization programmes to prevent new hepatitis B infections. In addition, it may be necessary to encourage HBsAg-positive people to follow healthier life-styles in order to prevent further progression of hepatitis B to liver cirrhosis and liver cancer.

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Related in: MedlinePlus

Hepatitis B surface antigen (HBsAg) seropositivity by age between 1998 and 2013, Republic of Korea. Dotted lines are order three polynomial trend line: R2=0.784 for 1998, 0.742 for 2005, and 0.812 in 2013.
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f2-epih-37-e2015055: Hepatitis B surface antigen (HBsAg) seropositivity by age between 1998 and 2013, Republic of Korea. Dotted lines are order three polynomial trend line: R2=0.784 for 1998, 0.742 for 2005, and 0.812 in 2013.

Mentions: HBsAg seropositivity results from 1998 to 2013 were compared by age. In order to test trends with minimizing variations that are caused by small numbers of subjects in each age group, order three polynomial trend lines with the highest goodness of fit were added. R2 values of trend lines were 0.784 in 1998 and 0.812 in 2013. Overall, seropositive rate increased and then decreased with age; however, the peaks appeared at age late 30s (35 to 39 years) in 1998 and age early 50s (50 to 54 years) in 2013. These results reflect the 15 year-interval between the two investigations. Seropositive rates were decreased by about 1% to 2% in all age cohorts over the 15 years. While seropositive rates in individuals in their late 50s or older were higher in 2013, those in their 10s and 20s were less than 1% and just over 1%, respectively (Figure 2).


Changes in seroprevalence of hepatitis B surface antigen and epidemiologic characteristics in the Republic of Korea, 1998-2013.

Lee H, Lee H, Cho Y, Oh K, Ki M - Epidemiol Health (2015)

Hepatitis B surface antigen (HBsAg) seropositivity by age between 1998 and 2013, Republic of Korea. Dotted lines are order three polynomial trend line: R2=0.784 for 1998, 0.742 for 2005, and 0.812 in 2013.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835708&req=5

f2-epih-37-e2015055: Hepatitis B surface antigen (HBsAg) seropositivity by age between 1998 and 2013, Republic of Korea. Dotted lines are order three polynomial trend line: R2=0.784 for 1998, 0.742 for 2005, and 0.812 in 2013.
Mentions: HBsAg seropositivity results from 1998 to 2013 were compared by age. In order to test trends with minimizing variations that are caused by small numbers of subjects in each age group, order three polynomial trend lines with the highest goodness of fit were added. R2 values of trend lines were 0.784 in 1998 and 0.812 in 2013. Overall, seropositive rate increased and then decreased with age; however, the peaks appeared at age late 30s (35 to 39 years) in 1998 and age early 50s (50 to 54 years) in 2013. These results reflect the 15 year-interval between the two investigations. Seropositive rates were decreased by about 1% to 2% in all age cohorts over the 15 years. While seropositive rates in individuals in their late 50s or older were higher in 2013, those in their 10s and 20s were less than 1% and just over 1%, respectively (Figure 2).

Bottom Line: HBsAg-positive people showed high values from two liver function tests, including glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and the prevalence rates of liver cirrhosis and liver cancer were also significantly high.While HBsAg seropositive rates tended to decline after 1998, there have been no significant changes over the most recent five years.In addition, it may be necessary to encourage HBsAg-positive people to follow healthier life-styles in order to prevent further progression of hepatitis B to liver cirrhosis and liver cancer.

View Article: PubMed Central - PubMed

Affiliation: Division of Health and Nutrition Survey, Centers for Disease Control and Prevention, Cheongju, Korea.

ABSTRACT

Objectives: This study investigated changes in hepatitis B seroprevalence from 1998 to 2013, and to identify differences in epidemiologic characteristics between hepatitis B surface antigen (HBsAg)-positive and HBsAg-negative people.

Methods: HBsAg seropositive rates were compared by year, sex, and age using the blood test data from the periods I to VI (1998-2013) of the Korea National Health and Nutrition Examination Survey. Interviews and self-administered surveys were conducted to collect data on health behavior, quality of life, comorbidities, and health care utilization.

Results: HBsAg seropositive rates in the Republic of Korea decreased from 4.6% in 1998 to 2.9% in 2008, and then remained the same for the next five years. While seropositive rates by age were the highest at 35 to 39 years of age in 1998, it peaked at 50 to 54 years of age in 2013. HBsAg-positive people showed high values from two liver function tests, including glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and the prevalence rates of liver cirrhosis and liver cancer were also significantly high. Indices for health behavior and quality of life showed no significant differences between HBsAg-positive and HBsAg-negative people.

Conclusions: While HBsAg seropositive rates tended to decline after 1998, there have been no significant changes over the most recent five years. We should focus on treatment of existing hepatitis B patients along with immunization programmes to prevent new hepatitis B infections. In addition, it may be necessary to encourage HBsAg-positive people to follow healthier life-styles in order to prevent further progression of hepatitis B to liver cirrhosis and liver cancer.

Show MeSH
Related in: MedlinePlus