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Changes in seroprevalence of hepatitis B surface antigen and epidemiologic characteristics in the Republic of Korea, 1998-2013.

Lee H, Lee H, Cho Y, Oh K, Ki M - Epidemiol Health (2015)

Bottom Line: HBsAg-positive people showed high values from two liver function tests, including glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and the prevalence rates of liver cirrhosis and liver cancer were also significantly high.While HBsAg seropositive rates tended to decline after 1998, there have been no significant changes over the most recent five years.In addition, it may be necessary to encourage HBsAg-positive people to follow healthier life-styles in order to prevent further progression of hepatitis B to liver cirrhosis and liver cancer.

View Article: PubMed Central - PubMed

Affiliation: Division of Health and Nutrition Survey, Centers for Disease Control and Prevention, Cheongju, Korea.

ABSTRACT

Objectives: This study investigated changes in hepatitis B seroprevalence from 1998 to 2013, and to identify differences in epidemiologic characteristics between hepatitis B surface antigen (HBsAg)-positive and HBsAg-negative people.

Methods: HBsAg seropositive rates were compared by year, sex, and age using the blood test data from the periods I to VI (1998-2013) of the Korea National Health and Nutrition Examination Survey. Interviews and self-administered surveys were conducted to collect data on health behavior, quality of life, comorbidities, and health care utilization.

Results: HBsAg seropositive rates in the Republic of Korea decreased from 4.6% in 1998 to 2.9% in 2008, and then remained the same for the next five years. While seropositive rates by age were the highest at 35 to 39 years of age in 1998, it peaked at 50 to 54 years of age in 2013. HBsAg-positive people showed high values from two liver function tests, including glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and the prevalence rates of liver cirrhosis and liver cancer were also significantly high. Indices for health behavior and quality of life showed no significant differences between HBsAg-positive and HBsAg-negative people.

Conclusions: While HBsAg seropositive rates tended to decline after 1998, there have been no significant changes over the most recent five years. We should focus on treatment of existing hepatitis B patients along with immunization programmes to prevent new hepatitis B infections. In addition, it may be necessary to encourage HBsAg-positive people to follow healthier life-styles in order to prevent further progression of hepatitis B to liver cirrhosis and liver cancer.

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Related in: MedlinePlus

Hepatitis B surface antigen (HBsAg) seropositivity by sex and year among ≥10 years based on the Korea National Health and Nutrition Examination Survey I to VI (1998-2013), Republic of Korea. Age standardization method is applied using the 2005 population estimates.
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f1-epih-37-e2015055: Hepatitis B surface antigen (HBsAg) seropositivity by sex and year among ≥10 years based on the Korea National Health and Nutrition Examination Survey I to VI (1998-2013), Republic of Korea. Age standardization method is applied using the 2005 population estimates.

Mentions: The HBsAg seropositive rate of subjects 10 years or older was 4.6% (5.1% for male and 4.0% for female) in 1998, and tended to decrease as shown to 2.9% in 2008. Thereafter it remained at the same level, ending around 2.9% (3.1% for male and 2.5% for female) in 2013. The seropositive rate of males were at its lowest (2.7%) in 2010 and suddenly increased to 4.8% in 2012, while the trend in the remaining years was consistent with the general pattern. In contrast, the seropositive rate of females rapidly declined to 3.1% in 2005, and then remained between 2.7% and 3.1% without significant changes. Males consistently had a higher infection rate than females, with a gap of 1.1% in 1998, whereas it reduced to 0.6% in 2013 (Figure 1).


Changes in seroprevalence of hepatitis B surface antigen and epidemiologic characteristics in the Republic of Korea, 1998-2013.

Lee H, Lee H, Cho Y, Oh K, Ki M - Epidemiol Health (2015)

Hepatitis B surface antigen (HBsAg) seropositivity by sex and year among ≥10 years based on the Korea National Health and Nutrition Examination Survey I to VI (1998-2013), Republic of Korea. Age standardization method is applied using the 2005 population estimates.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835708&req=5

f1-epih-37-e2015055: Hepatitis B surface antigen (HBsAg) seropositivity by sex and year among ≥10 years based on the Korea National Health and Nutrition Examination Survey I to VI (1998-2013), Republic of Korea. Age standardization method is applied using the 2005 population estimates.
Mentions: The HBsAg seropositive rate of subjects 10 years or older was 4.6% (5.1% for male and 4.0% for female) in 1998, and tended to decrease as shown to 2.9% in 2008. Thereafter it remained at the same level, ending around 2.9% (3.1% for male and 2.5% for female) in 2013. The seropositive rate of males were at its lowest (2.7%) in 2010 and suddenly increased to 4.8% in 2012, while the trend in the remaining years was consistent with the general pattern. In contrast, the seropositive rate of females rapidly declined to 3.1% in 2005, and then remained between 2.7% and 3.1% without significant changes. Males consistently had a higher infection rate than females, with a gap of 1.1% in 1998, whereas it reduced to 0.6% in 2013 (Figure 1).

Bottom Line: HBsAg-positive people showed high values from two liver function tests, including glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and the prevalence rates of liver cirrhosis and liver cancer were also significantly high.While HBsAg seropositive rates tended to decline after 1998, there have been no significant changes over the most recent five years.In addition, it may be necessary to encourage HBsAg-positive people to follow healthier life-styles in order to prevent further progression of hepatitis B to liver cirrhosis and liver cancer.

View Article: PubMed Central - PubMed

Affiliation: Division of Health and Nutrition Survey, Centers for Disease Control and Prevention, Cheongju, Korea.

ABSTRACT

Objectives: This study investigated changes in hepatitis B seroprevalence from 1998 to 2013, and to identify differences in epidemiologic characteristics between hepatitis B surface antigen (HBsAg)-positive and HBsAg-negative people.

Methods: HBsAg seropositive rates were compared by year, sex, and age using the blood test data from the periods I to VI (1998-2013) of the Korea National Health and Nutrition Examination Survey. Interviews and self-administered surveys were conducted to collect data on health behavior, quality of life, comorbidities, and health care utilization.

Results: HBsAg seropositive rates in the Republic of Korea decreased from 4.6% in 1998 to 2.9% in 2008, and then remained the same for the next five years. While seropositive rates by age were the highest at 35 to 39 years of age in 1998, it peaked at 50 to 54 years of age in 2013. HBsAg-positive people showed high values from two liver function tests, including glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and the prevalence rates of liver cirrhosis and liver cancer were also significantly high. Indices for health behavior and quality of life showed no significant differences between HBsAg-positive and HBsAg-negative people.

Conclusions: While HBsAg seropositive rates tended to decline after 1998, there have been no significant changes over the most recent five years. We should focus on treatment of existing hepatitis B patients along with immunization programmes to prevent new hepatitis B infections. In addition, it may be necessary to encourage HBsAg-positive people to follow healthier life-styles in order to prevent further progression of hepatitis B to liver cirrhosis and liver cancer.

Show MeSH
Related in: MedlinePlus