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Circulating Fatty Acid Synthase in pregnant women: Relationship to blood pressure, maternal metabolism and newborn parameters.

Carreras-Badosa G, Prats-Puig A, Puig T, Vázquez-Ruíz M, Bruel M, Mendoza E, de Zegher F, Ibáñez L, López-Bermejo A, Bassols J - Sci Rep (2016)

Bottom Line: Placental FASN expression related positively to circulating FASN (p < 0.005) and negatively to placental weight (p < 0.05).Our observations suggest a physiological role of placental FASN in human pregnancy.Future studies will clarify whether circulating FASN of placental origin does actually regulate placental and fetal growth, and (thereby) has a favourable influence on the pregnant mother's insulin sensitivity and blood pressure.

View Article: PubMed Central - PubMed

Affiliation: Pediatrics, Girona Institute for Biomedical Research, 17007 Girona, Spain.

ABSTRACT
The enzyme FASN (fatty acid synthase) is potentially related with hypertension and metabolic dysfunction. FASN is highly expressed in the human placenta. We aimed to investigate the relationship circulating FASN has with blood pressure, maternal metabolism and newborn parameters in healthy pregnant women. Circulating FASN was assessed in 115 asymptomatic pregnant women in the second trimester of gestation along with C-peptide, fasting glucose and insulin, post-load glucose lipids, HMW-adiponectin and blood pressure (the latter was assessed in each trimester of gestation). At birth, newborns and placentas were weighed. FASN expression was also able to be assessed in 80 placentas. Higher circulating FASN was associated with lower systolic blood pressure (SBP), with a more favourable metabolic phenotype (lower fasting glucose and insulin, post load glucose, HbAc1, HOMA-IR and C-peptide), and with lower placental and birth weight (all p < 0.05 to p < 0.001). Placental FASN expression related positively to circulating FASN (p < 0.005) and negatively to placental weight (p < 0.05). Our observations suggest a physiological role of placental FASN in human pregnancy. Future studies will clarify whether circulating FASN of placental origin does actually regulate placental and fetal growth, and (thereby) has a favourable influence on the pregnant mother's insulin sensitivity and blood pressure.

No MeSH data available.


Related in: MedlinePlus

Distribution of metabolic parameters: blood pressure [second- and third-trimester systolic blood pressure (SBP)], HMW-adiponectin, pre- and post-load glucose, insulin, HOMA-IR and placental FASN expression according to tertiles of circulating FASN (1st: 0.1–1.4 ng/ml; 2nd: 1.4–4.3 ng/ml and 3rd: 4.5–18.8 ng/ml).Data are means and SEM.
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f1: Distribution of metabolic parameters: blood pressure [second- and third-trimester systolic blood pressure (SBP)], HMW-adiponectin, pre- and post-load glucose, insulin, HOMA-IR and placental FASN expression according to tertiles of circulating FASN (1st: 0.1–1.4 ng/ml; 2nd: 1.4–4.3 ng/ml and 3rd: 4.5–18.8 ng/ml).Data are means and SEM.

Mentions: A threshold association was evident for circulating FASN and BP, metabolic variables and the parameters of newborns, with women in the highest tertile of circulating FASN exhibiting lower SBP in the second and third trimester of gestation, DBP in the third trimester, fasting glucose and insulin, post load glucose HOMA-IR, placental FASN expression, placental weight and birth weight SDS, and higher HMW-adiponectin compared to other tertiles of circulating FASN (Table 3 and Fig. 1 and Suppl Fig. 1).


Circulating Fatty Acid Synthase in pregnant women: Relationship to blood pressure, maternal metabolism and newborn parameters.

Carreras-Badosa G, Prats-Puig A, Puig T, Vázquez-Ruíz M, Bruel M, Mendoza E, de Zegher F, Ibáñez L, López-Bermejo A, Bassols J - Sci Rep (2016)

Distribution of metabolic parameters: blood pressure [second- and third-trimester systolic blood pressure (SBP)], HMW-adiponectin, pre- and post-load glucose, insulin, HOMA-IR and placental FASN expression according to tertiles of circulating FASN (1st: 0.1–1.4 ng/ml; 2nd: 1.4–4.3 ng/ml and 3rd: 4.5–18.8 ng/ml).Data are means and SEM.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835700&req=5

f1: Distribution of metabolic parameters: blood pressure [second- and third-trimester systolic blood pressure (SBP)], HMW-adiponectin, pre- and post-load glucose, insulin, HOMA-IR and placental FASN expression according to tertiles of circulating FASN (1st: 0.1–1.4 ng/ml; 2nd: 1.4–4.3 ng/ml and 3rd: 4.5–18.8 ng/ml).Data are means and SEM.
Mentions: A threshold association was evident for circulating FASN and BP, metabolic variables and the parameters of newborns, with women in the highest tertile of circulating FASN exhibiting lower SBP in the second and third trimester of gestation, DBP in the third trimester, fasting glucose and insulin, post load glucose HOMA-IR, placental FASN expression, placental weight and birth weight SDS, and higher HMW-adiponectin compared to other tertiles of circulating FASN (Table 3 and Fig. 1 and Suppl Fig. 1).

Bottom Line: Placental FASN expression related positively to circulating FASN (p < 0.005) and negatively to placental weight (p < 0.05).Our observations suggest a physiological role of placental FASN in human pregnancy.Future studies will clarify whether circulating FASN of placental origin does actually regulate placental and fetal growth, and (thereby) has a favourable influence on the pregnant mother's insulin sensitivity and blood pressure.

View Article: PubMed Central - PubMed

Affiliation: Pediatrics, Girona Institute for Biomedical Research, 17007 Girona, Spain.

ABSTRACT
The enzyme FASN (fatty acid synthase) is potentially related with hypertension and metabolic dysfunction. FASN is highly expressed in the human placenta. We aimed to investigate the relationship circulating FASN has with blood pressure, maternal metabolism and newborn parameters in healthy pregnant women. Circulating FASN was assessed in 115 asymptomatic pregnant women in the second trimester of gestation along with C-peptide, fasting glucose and insulin, post-load glucose lipids, HMW-adiponectin and blood pressure (the latter was assessed in each trimester of gestation). At birth, newborns and placentas were weighed. FASN expression was also able to be assessed in 80 placentas. Higher circulating FASN was associated with lower systolic blood pressure (SBP), with a more favourable metabolic phenotype (lower fasting glucose and insulin, post load glucose, HbAc1, HOMA-IR and C-peptide), and with lower placental and birth weight (all p < 0.05 to p < 0.001). Placental FASN expression related positively to circulating FASN (p < 0.005) and negatively to placental weight (p < 0.05). Our observations suggest a physiological role of placental FASN in human pregnancy. Future studies will clarify whether circulating FASN of placental origin does actually regulate placental and fetal growth, and (thereby) has a favourable influence on the pregnant mother's insulin sensitivity and blood pressure.

No MeSH data available.


Related in: MedlinePlus