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Dynamic Changes of Functional Pain Connectome in Women with Primary Dysmenorrhea.

Wu TH, Tu CH, Chao HT, Li WC, Low I, Chuang CY, Yeh TC, Cheng CM, Chou CC, Chen LF, Hsieh JC - Sci Rep (2016)

Bottom Line: PDM women exhibited a trait-related ReHo reduction in the ventromedial prefrontal cortex, part of the default mode network (DMN), during the periovulatory phase.The altered DMN-sensorimotor network may be an ongoing representation of cumulative menstrual pain.The findings indicate that women with long-term PDM may develop adaptive neuroplasticity and functional reorganization with a network shift from affective processing of salience to the cognitive modulation of pain.

View Article: PubMed Central - PubMed

Affiliation: Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

ABSTRACT
Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and between systems (or networks) in shaping pain experience and behavior, the intra-regional functional connectivity (FC) in the hub regions of the systems may be altered and the functional interactions in terms of inter-regional FCs among the networks may be reorganized to cope with the repeated stress of menstrual pain in PDM. Forty-six otherwise healthy PDM subjects and 49 age-matched, healthy female control subjects were enrolled. Intra- and inter-regional FC were assessed using regional homogeneity (ReHo) and ReHo-seeded FC analyses, respectively. PDM women exhibited a trait-related ReHo reduction in the ventromedial prefrontal cortex, part of the default mode network (DMN), during the periovulatory phase. The trait-related hypoconnectivity of DMN-salience network and hyperconnectivity of DMN-executive control network across the menstrual cycle featured a dynamic transition from affective processing of pain salience to cognitive modulation. The altered DMN-sensorimotor network may be an ongoing representation of cumulative menstrual pain. The findings indicate that women with long-term PDM may develop adaptive neuroplasticity and functional reorganization with a network shift from affective processing of salience to the cognitive modulation of pain.

No MeSH data available.


Related in: MedlinePlus

Correlation between FC and anxiety score inverses across phases in PDM.The Lt vmPFC-Rt insula, -Lt insula and -bilateral dorsal anterior cingulate cortex (dACC) FCs are positively correlated with BAI during the POV phase but negatively correlated with BAI during the MENS phase. Original FC values were used for the correlation to avoid artificial and inadvertent zeroing. Blue regions are associated with lower correlation with BAI during MENS phase. Significance thresholded at the uncorrected voxel level p = 0.005 followed by the FWE-corrected cluster level p = 0.05. BAI, Beck Anxiety Inventory; Lt, left; Rt, right.
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f3: Correlation between FC and anxiety score inverses across phases in PDM.The Lt vmPFC-Rt insula, -Lt insula and -bilateral dorsal anterior cingulate cortex (dACC) FCs are positively correlated with BAI during the POV phase but negatively correlated with BAI during the MENS phase. Original FC values were used for the correlation to avoid artificial and inadvertent zeroing. Blue regions are associated with lower correlation with BAI during MENS phase. Significance thresholded at the uncorrected voxel level p = 0.005 followed by the FWE-corrected cluster level p = 0.05. BAI, Beck Anxiety Inventory; Lt, left; Rt, right.

Mentions: In the PDM group, the FC of the left vmPFC-bilateral posterior-mid insula (DMN-pain matrix connectivity) and -dACC (DMN-pain matrix connectivity) were more correlated with BAI during the POV phase when compared to the MENS phase (Fig. 3; Table 4). The FCs of the left vmPFC-bilateral midcingulate cortex and -right middle frontal gyrus positively correlated with BAI, and the FC of the left vmPFC-bilateral declive negatively correlated with BAI during the POV phase. The FC of the right vmPFC-right inferior temporal gyrus and -left declive circuit negatively correlated with BAI during the POV phase. The FCs of the aIPS-bilateral rectal gyrus and -right cerebellum connectivity and BAI were significantly more correlated during the POV phase when compared with the MENS phase. The FC of the aIPS-bilateral rectal gyrus positively correlated with BAI and the FC of the aIPS-left precuneus negatively correlated with BAI during the POV phase. For brain-behavioral correlations, there was no significant correlation during the MENS phase (Table 4).


Dynamic Changes of Functional Pain Connectome in Women with Primary Dysmenorrhea.

Wu TH, Tu CH, Chao HT, Li WC, Low I, Chuang CY, Yeh TC, Cheng CM, Chou CC, Chen LF, Hsieh JC - Sci Rep (2016)

Correlation between FC and anxiety score inverses across phases in PDM.The Lt vmPFC-Rt insula, -Lt insula and -bilateral dorsal anterior cingulate cortex (dACC) FCs are positively correlated with BAI during the POV phase but negatively correlated with BAI during the MENS phase. Original FC values were used for the correlation to avoid artificial and inadvertent zeroing. Blue regions are associated with lower correlation with BAI during MENS phase. Significance thresholded at the uncorrected voxel level p = 0.005 followed by the FWE-corrected cluster level p = 0.05. BAI, Beck Anxiety Inventory; Lt, left; Rt, right.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835697&req=5

f3: Correlation between FC and anxiety score inverses across phases in PDM.The Lt vmPFC-Rt insula, -Lt insula and -bilateral dorsal anterior cingulate cortex (dACC) FCs are positively correlated with BAI during the POV phase but negatively correlated with BAI during the MENS phase. Original FC values were used for the correlation to avoid artificial and inadvertent zeroing. Blue regions are associated with lower correlation with BAI during MENS phase. Significance thresholded at the uncorrected voxel level p = 0.005 followed by the FWE-corrected cluster level p = 0.05. BAI, Beck Anxiety Inventory; Lt, left; Rt, right.
Mentions: In the PDM group, the FC of the left vmPFC-bilateral posterior-mid insula (DMN-pain matrix connectivity) and -dACC (DMN-pain matrix connectivity) were more correlated with BAI during the POV phase when compared to the MENS phase (Fig. 3; Table 4). The FCs of the left vmPFC-bilateral midcingulate cortex and -right middle frontal gyrus positively correlated with BAI, and the FC of the left vmPFC-bilateral declive negatively correlated with BAI during the POV phase. The FC of the right vmPFC-right inferior temporal gyrus and -left declive circuit negatively correlated with BAI during the POV phase. The FCs of the aIPS-bilateral rectal gyrus and -right cerebellum connectivity and BAI were significantly more correlated during the POV phase when compared with the MENS phase. The FC of the aIPS-bilateral rectal gyrus positively correlated with BAI and the FC of the aIPS-left precuneus negatively correlated with BAI during the POV phase. For brain-behavioral correlations, there was no significant correlation during the MENS phase (Table 4).

Bottom Line: PDM women exhibited a trait-related ReHo reduction in the ventromedial prefrontal cortex, part of the default mode network (DMN), during the periovulatory phase.The altered DMN-sensorimotor network may be an ongoing representation of cumulative menstrual pain.The findings indicate that women with long-term PDM may develop adaptive neuroplasticity and functional reorganization with a network shift from affective processing of salience to the cognitive modulation of pain.

View Article: PubMed Central - PubMed

Affiliation: Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

ABSTRACT
Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and between systems (or networks) in shaping pain experience and behavior, the intra-regional functional connectivity (FC) in the hub regions of the systems may be altered and the functional interactions in terms of inter-regional FCs among the networks may be reorganized to cope with the repeated stress of menstrual pain in PDM. Forty-six otherwise healthy PDM subjects and 49 age-matched, healthy female control subjects were enrolled. Intra- and inter-regional FC were assessed using regional homogeneity (ReHo) and ReHo-seeded FC analyses, respectively. PDM women exhibited a trait-related ReHo reduction in the ventromedial prefrontal cortex, part of the default mode network (DMN), during the periovulatory phase. The trait-related hypoconnectivity of DMN-salience network and hyperconnectivity of DMN-executive control network across the menstrual cycle featured a dynamic transition from affective processing of pain salience to cognitive modulation. The altered DMN-sensorimotor network may be an ongoing representation of cumulative menstrual pain. The findings indicate that women with long-term PDM may develop adaptive neuroplasticity and functional reorganization with a network shift from affective processing of salience to the cognitive modulation of pain.

No MeSH data available.


Related in: MedlinePlus