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Opening the Debate: How to Fulfill the Need for Physicians' Training in Circadian-Related Topics in a Full Medical School Curriculum.

Selfridge JM, Moyer K, Capelluto DG, Finkielstein CV - J Circadian Rhythms (2015)

Bottom Line: The diverse range of illness associated with altered rhythms suggests that physicians in various fields will see its impact in their patients.However, medical education, with an already full curriculum, struggles to address this issue.Here, we emphasize the need for incorporating the topic of circadian rhythms in the medical curriculum and propose strategies to accomplish this goal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Integrated Cellular Responses Laboratory, Department of Biological Sciences, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia.

ABSTRACT

Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological activities. Their importance to human health is becoming apparent; they are deranged by shift work and jet-lag and in disparate conditions such as insomnia, sleep syndromes, coronary heart attacks, and depression, and are endogenous factors that contribute to cancer development and progression.

Discussion: As evidence of the circadian connection to human health has grown, so has the number of Americans experiencing disruption of circadian rhythms due to the demands of an industrialized society. Today, there is a growing work force that experiences night shift work and time-zone shifts shaping the demands on physicians to best meet the needs of patients exposed to chronic circadian disruptions. The diverse range of illness associated with altered rhythms suggests that physicians in various fields will see its impact in their patients. However, medical education, with an already full curriculum, struggles to address this issue.

Summary: Here, we emphasize the need for incorporating the topic of circadian rhythms in the medical curriculum and propose strategies to accomplish this goal.

No MeSH data available.


Related in: MedlinePlus

Circadian acrophase chart for various parameters in plasma.
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Figure 1: Circadian acrophase chart for various parameters in plasma.

Mentions: First, we envision an approach in which circadian biology becomes part of theconversation early on in medical school by adding the topic to existing blocksof lectures allocated to, for example, metabolism, endocrine regulation, andgene expression; all of which are processes that have been proven to be linkedto circadian rhythms on a molecular level [12131415]. Applicationof circadian rhythms to clinical medicine is of relevance as the time of day isan important variable when running medical tests [e.g., whenmeasuring systolic and diastolic blood pressure, intraocular pressure, insulinresponse, coagulation, and hormonal studies [16171819], see examplesin Figure 1] and most likely influencesdiagnosis and pharmacotherapy. In addition, conceptualization of biologicalrhythms in laboratory medicine is certainly relevant to health professionals asit represents a challenge, helps improve diagnostic accuracy, and is anopportunity to better assess the therapeutic efficiency of a given drug.Patient’s samples collected at different times can significantly affect avariety of common diagnostic measurements [2021] and reference rangeshave been defined to make the correct diagnosis of medical conditions anddisease states [22].


Opening the Debate: How to Fulfill the Need for Physicians' Training in Circadian-Related Topics in a Full Medical School Curriculum.

Selfridge JM, Moyer K, Capelluto DG, Finkielstein CV - J Circadian Rhythms (2015)

Circadian acrophase chart for various parameters in plasma.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835682&req=5

Figure 1: Circadian acrophase chart for various parameters in plasma.
Mentions: First, we envision an approach in which circadian biology becomes part of theconversation early on in medical school by adding the topic to existing blocksof lectures allocated to, for example, metabolism, endocrine regulation, andgene expression; all of which are processes that have been proven to be linkedto circadian rhythms on a molecular level [12131415]. Applicationof circadian rhythms to clinical medicine is of relevance as the time of day isan important variable when running medical tests [e.g., whenmeasuring systolic and diastolic blood pressure, intraocular pressure, insulinresponse, coagulation, and hormonal studies [16171819], see examplesin Figure 1] and most likely influencesdiagnosis and pharmacotherapy. In addition, conceptualization of biologicalrhythms in laboratory medicine is certainly relevant to health professionals asit represents a challenge, helps improve diagnostic accuracy, and is anopportunity to better assess the therapeutic efficiency of a given drug.Patient’s samples collected at different times can significantly affect avariety of common diagnostic measurements [2021] and reference rangeshave been defined to make the correct diagnosis of medical conditions anddisease states [22].

Bottom Line: The diverse range of illness associated with altered rhythms suggests that physicians in various fields will see its impact in their patients.However, medical education, with an already full curriculum, struggles to address this issue.Here, we emphasize the need for incorporating the topic of circadian rhythms in the medical curriculum and propose strategies to accomplish this goal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Integrated Cellular Responses Laboratory, Department of Biological Sciences, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia.

ABSTRACT

Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological activities. Their importance to human health is becoming apparent; they are deranged by shift work and jet-lag and in disparate conditions such as insomnia, sleep syndromes, coronary heart attacks, and depression, and are endogenous factors that contribute to cancer development and progression.

Discussion: As evidence of the circadian connection to human health has grown, so has the number of Americans experiencing disruption of circadian rhythms due to the demands of an industrialized society. Today, there is a growing work force that experiences night shift work and time-zone shifts shaping the demands on physicians to best meet the needs of patients exposed to chronic circadian disruptions. The diverse range of illness associated with altered rhythms suggests that physicians in various fields will see its impact in their patients. However, medical education, with an already full curriculum, struggles to address this issue.

Summary: Here, we emphasize the need for incorporating the topic of circadian rhythms in the medical curriculum and propose strategies to accomplish this goal.

No MeSH data available.


Related in: MedlinePlus