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Effect of Opioid on Adult Hippocampal Neurogenesis.

Zhang Y, Loh HH, Law PY - ScientificWorldJournal (2016)

Bottom Line: During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed.Here, we review the most recent works on opiate drugs' effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms.We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455-0217, USA.

ABSTRACT
During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. Here, we review the most recent works on opiate drugs' effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms. We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation. We also discuss the consequent impact of regulation of adult neurogenesis in animal's opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.

No MeSH data available.


Related in: MedlinePlus

Different types of opioids act on different stages of adult neurogenesis in the DG (with expression pattern of specific markers).
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Related In: Results  -  Collection


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fig1: Different types of opioids act on different stages of adult neurogenesis in the DG (with expression pattern of specific markers).

Mentions: Overall, we summarize that the effects of opioid on NSPCs may vary among different drugs and experimental methods, and one opioid receptor agonist may act on multiple stages of NSPCs, including proliferation, differentiation, and survival (Figure 1).


Effect of Opioid on Adult Hippocampal Neurogenesis.

Zhang Y, Loh HH, Law PY - ScientificWorldJournal (2016)

Different types of opioids act on different stages of adult neurogenesis in the DG (with expression pattern of specific markers).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4835638&req=5

fig1: Different types of opioids act on different stages of adult neurogenesis in the DG (with expression pattern of specific markers).
Mentions: Overall, we summarize that the effects of opioid on NSPCs may vary among different drugs and experimental methods, and one opioid receptor agonist may act on multiple stages of NSPCs, including proliferation, differentiation, and survival (Figure 1).

Bottom Line: During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed.Here, we review the most recent works on opiate drugs' effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms.We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455-0217, USA.

ABSTRACT
During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid. Here, we review the most recent works on opiate drugs' effect on different developmental stages of adult hippocampal neurogenesis, as well as the possible underlying mechanisms. We conclude that opiate drugs in general cause a loss of newly born neural progenitors in the subgranular zone of dentate gyrus, by either modulating proliferation or interfering with differentiation and maturation. We also discuss the consequent impact of regulation of adult neurogenesis in animal's opioid addiction behavior. We further look into the future directions in studying the convergence between the adult neurogenesis field and opioid addiction field, since the adult-born granular cells were shown to play a role in neuroplasticity and may help to reduce the vulnerability to drug craving and relapse.

No MeSH data available.


Related in: MedlinePlus