Reversible Fluindione-Induced Chronic Interstitial Nephritis.
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Most cases occurred soon after the onset of treatment.We report a unique case of severe subacute fluindione-induced IN diagnosed 2 years after the treatment was begun.Renal function dramatically improved after fluindione withdrawal and steroid therapy.
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PubMed Central - PubMed
Affiliation: Department of Nephrology, Dialysis, and Renal Transplantation, CHU Besançon, 25030 Besançon, France.
ABSTRACT
Fluindione is well known to induce acute drug-induced interstitial nephritis (IN). Most cases occurred soon after the onset of treatment. We report a unique case of severe subacute fluindione-induced IN diagnosed 2 years after the treatment was begun. Renal function dramatically improved after fluindione withdrawal and steroid therapy. No MeSH data available. Related in: MedlinePlus |
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fig1: Kidney biopsy. Optical microscopy showed significant interstitial lymphocytic infiltration (HES). Mentions: Kidney biopsy was performed. Optical microscopy showed tubulointerstitial nephritis with marked inflammation T cell CD3+, few eosinophils, and severe fibrosis with tubular atrophy. Immunofluorescent studies did not reveal any immune deposits (Figures 1-2). |
View Article: PubMed Central - PubMed
Affiliation: Department of Nephrology, Dialysis, and Renal Transplantation, CHU Besançon, 25030 Besançon, France.
No MeSH data available.