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Translation and Validation of a Korean Version of the Xerostomia Inventory in Patients with Primary Sjögren's Syndrome.

Lee J, Koh JH, Kwok SK, Park SH - J. Korean Med. Sci. (2016)

Bottom Line: Cronbach's alpha for internal consistency was 0.868, and the ICC for test-retest reliability ranged from 0.48 to 0.827, with a median value of 0.72.Moderate negative correlations between XI score and stimulated SFR, unstimulated SFR, and differential (stimulated minus unstimulated) SFR were observed (Spearman's rho, ρ = -0.515, -0.447, and -0.482, respectively; P < 0.001).In conclusion, the Korean version of the XI is a reliable tool to estimate the severity of xerostomia in patients with pSS.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea .

ABSTRACT
This study was conducted to generate and validate a cross-culturally adapted Korean version of the xerostomia inventory (XI), an 11-item questionnaire designed to measure the severity of xerostomia. The original English version of the XI was translated into Korean according to the guidelines for cross-cultural adaptation of health-related quality-of-life measures. Among a prospective cohort of primary Sjögren's syndrome (pSS) in Korea, 194 patients were analyzed. Internal consistency was evaluated by using Cronbach's alpha, and test-retest reliability was obtained by using an intraclass correlation coefficient (ICC) analysis. Construct validity was investigated by performing a correlation analysis between XI total score and salivary flow rate (SFR). Cronbach's alpha for internal consistency was 0.868, and the ICC for test-retest reliability ranged from 0.48 to 0.827, with a median value of 0.72. Moderate negative correlations between XI score and stimulated SFR, unstimulated SFR, and differential (stimulated minus unstimulated) SFR were observed (Spearman's rho, ρ = -0.515, -0.447, and -0.482, respectively; P < 0.001). The correlation analysis between the visual analogue scale (VAS) score of overall dryness and SFR indicated a smaller ρ value (-0.235 [P = 0.006], -0.243 [P = 0.002], and -0.252 [P = 0.003], respectively), which supports that XI more accurately reflects the degree of xerostomia in the pSS patients. In conclusion, the Korean version of the XI is a reliable tool to estimate the severity of xerostomia in patients with pSS.

No MeSH data available.


Related in: MedlinePlus

Spearman’s correlation between the Xerostomia inventory (XI) total scores and salivary flow rate (SFR)s. The correlations between XI total scores and the resting (A), stimulated (B), and differential (stimulated minus resting) (C) SFRs were analyzed. The dotted lines depict 95% confidence intervals.
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Figure 1: Spearman’s correlation between the Xerostomia inventory (XI) total scores and salivary flow rate (SFR)s. The correlations between XI total scores and the resting (A), stimulated (B), and differential (stimulated minus resting) (C) SFRs were analyzed. The dotted lines depict 95% confidence intervals.

Mentions: To demonstrate construct validity, the correlation between the total XI-K scores and the resting, stimulated, and differential (stimulated minus resting) SFRs was evaluated. The results showed that Spearman’s rho was −0.447 for resting SFR, −0.515 for stimulated SFR, and −0.482 for differential SFR (P < 0.001; Fig. 1). The construct validity of the XI was originally evaluated by using the single standard question, “How often does your mouth feel dry?”, with the following response options: never, occasionally, frequently, and always (1016). The question was also administered in our study subjects. Spearman’s correlation coefficient was 0.772 (P < 0.001). We also checked the correlation between XI score and simple VAS score for dryness. The results showed that Spearman’s rho was 0.492 (P < 0.001), which showed a moderate positive correlation.


Translation and Validation of a Korean Version of the Xerostomia Inventory in Patients with Primary Sjögren's Syndrome.

Lee J, Koh JH, Kwok SK, Park SH - J. Korean Med. Sci. (2016)

Spearman’s correlation between the Xerostomia inventory (XI) total scores and salivary flow rate (SFR)s. The correlations between XI total scores and the resting (A), stimulated (B), and differential (stimulated minus resting) (C) SFRs were analyzed. The dotted lines depict 95% confidence intervals.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835597&req=5

Figure 1: Spearman’s correlation between the Xerostomia inventory (XI) total scores and salivary flow rate (SFR)s. The correlations between XI total scores and the resting (A), stimulated (B), and differential (stimulated minus resting) (C) SFRs were analyzed. The dotted lines depict 95% confidence intervals.
Mentions: To demonstrate construct validity, the correlation between the total XI-K scores and the resting, stimulated, and differential (stimulated minus resting) SFRs was evaluated. The results showed that Spearman’s rho was −0.447 for resting SFR, −0.515 for stimulated SFR, and −0.482 for differential SFR (P < 0.001; Fig. 1). The construct validity of the XI was originally evaluated by using the single standard question, “How often does your mouth feel dry?”, with the following response options: never, occasionally, frequently, and always (1016). The question was also administered in our study subjects. Spearman’s correlation coefficient was 0.772 (P < 0.001). We also checked the correlation between XI score and simple VAS score for dryness. The results showed that Spearman’s rho was 0.492 (P < 0.001), which showed a moderate positive correlation.

Bottom Line: Cronbach's alpha for internal consistency was 0.868, and the ICC for test-retest reliability ranged from 0.48 to 0.827, with a median value of 0.72.Moderate negative correlations between XI score and stimulated SFR, unstimulated SFR, and differential (stimulated minus unstimulated) SFR were observed (Spearman's rho, ρ = -0.515, -0.447, and -0.482, respectively; P < 0.001).In conclusion, the Korean version of the XI is a reliable tool to estimate the severity of xerostomia in patients with pSS.

View Article: PubMed Central - PubMed

Affiliation: Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea .

ABSTRACT
This study was conducted to generate and validate a cross-culturally adapted Korean version of the xerostomia inventory (XI), an 11-item questionnaire designed to measure the severity of xerostomia. The original English version of the XI was translated into Korean according to the guidelines for cross-cultural adaptation of health-related quality-of-life measures. Among a prospective cohort of primary Sjögren's syndrome (pSS) in Korea, 194 patients were analyzed. Internal consistency was evaluated by using Cronbach's alpha, and test-retest reliability was obtained by using an intraclass correlation coefficient (ICC) analysis. Construct validity was investigated by performing a correlation analysis between XI total score and salivary flow rate (SFR). Cronbach's alpha for internal consistency was 0.868, and the ICC for test-retest reliability ranged from 0.48 to 0.827, with a median value of 0.72. Moderate negative correlations between XI score and stimulated SFR, unstimulated SFR, and differential (stimulated minus unstimulated) SFR were observed (Spearman's rho, ρ = -0.515, -0.447, and -0.482, respectively; P < 0.001). The correlation analysis between the visual analogue scale (VAS) score of overall dryness and SFR indicated a smaller ρ value (-0.235 [P = 0.006], -0.243 [P = 0.002], and -0.252 [P = 0.003], respectively), which supports that XI more accurately reflects the degree of xerostomia in the pSS patients. In conclusion, the Korean version of the XI is a reliable tool to estimate the severity of xerostomia in patients with pSS.

No MeSH data available.


Related in: MedlinePlus