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Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan.

Scialò F, Sriram A, Fernández-Ayala D, Gubina N, Lõhmus M, Nelson G, Logan A, Cooper HM, Navas P, Enríquez JA, Murphy MP, Sanz A - Cell Metab. (2016)

Bottom Line: Here we show that the site of ROS production significantly contributes to their apparent dual nature.Furthermore, preventing ubiquinone reduction, through knockdown of PINK1, shortens lifespan and accelerates aging; phenotypes that are rescued by increasing reverse electron transport.These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging.

View Article: PubMed Central - PubMed

Affiliation: Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

No MeSH data available.


Related in: MedlinePlus

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Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan.

Scialò F, Sriram A, Fernández-Ayala D, Gubina N, Lõhmus M, Nelson G, Logan A, Cooper HM, Navas P, Enríquez JA, Murphy MP, Sanz A - Cell Metab. (2016)

© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4835580&req=5

Bottom Line: Here we show that the site of ROS production significantly contributes to their apparent dual nature.Furthermore, preventing ubiquinone reduction, through knockdown of PINK1, shortens lifespan and accelerates aging; phenotypes that are rescued by increasing reverse electron transport.These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging.

View Article: PubMed Central - PubMed

Affiliation: Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

No MeSH data available.


Related in: MedlinePlus