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Mesolimbic Dopamine Encodes Prediction Errors in a State-Dependent Manner.

Papageorgiou GK, Baudonnat M, Cucca F, Walton ME - Cell Rep (2016)

Bottom Line: Mesolimbic dopamine encodes the benefits of a course of action.These changes were rapid and selective, with dopamine release returning to pre-satiation patterns when the animals were re-tested in a standard food-restricted state.Such rapid and selective adaptation of dopamine-associated value signals could provide an important signal to promote efficient foraging for a varied diet.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Psychology, University of Oxford, 9 South Parks Road, Oxford OX1 3UD, UK. Electronic address: georgios.papageorgiou@psy.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Cue-Elicited Dopamine Release on First Trials of the Session(A) Average dopamine levels in a 5-s window after cue onset on the first food/sucrose solution trial in baselines A and B. Baseline data are divided into “valued” (Val) or “devalued” (Deval) based on which reinforcer the animals had free access to in devaluation A.(B) Average dopamine signals after cue onset on the first food/sucrose solution trial in the baseline and devaluation sessions. Baseline data here are divided up based on which reinforcer the animals had free access to in the subsequent devaluation session.(C) Average dopamine levels in a 2-s post-lever extension window (prior to reward delivery) on the first food or sucrose solution trial, averaged across the devaluation sessions.Levels were significantly reduced on the first devalued trial compared to the first valued trial (∗p < 0.05, ANOVA). All averages indicate mean ± SEM. DA, dopamine.
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fig4: Cue-Elicited Dopamine Release on First Trials of the Session(A) Average dopamine levels in a 5-s window after cue onset on the first food/sucrose solution trial in baselines A and B. Baseline data are divided into “valued” (Val) or “devalued” (Deval) based on which reinforcer the animals had free access to in devaluation A.(B) Average dopamine signals after cue onset on the first food/sucrose solution trial in the baseline and devaluation sessions. Baseline data here are divided up based on which reinforcer the animals had free access to in the subsequent devaluation session.(C) Average dopamine levels in a 2-s post-lever extension window (prior to reward delivery) on the first food or sucrose solution trial, averaged across the devaluation sessions.Levels were significantly reduced on the first devalued trial compared to the first valued trial (∗p < 0.05, ANOVA). All averages indicate mean ± SEM. DA, dopamine.

Mentions: Although these analyses show a rapid influence of selective satiety on dopamine release, it is not clear whether this is purely an experience-dependent effect based on learning the value of the options in the new state or whether dopamine cue signals can update even before the devalued reward is consumed during the session. To examine this, we analyzed dopamine release elicited by the first presentation in the session of both the valued and devalued options (Figure 4A). This revealed an overall attenuation of dopamine release on the initial trial of the devaluation sessions compared to the preceding baseline session (main effect of session type: F(1, 6) = 12.44, p = 0.012, including trial order as a between-subjects factors). However, this reduction was not significantly greater after first presentation of the cue associated with the currently devalued option than after that associated with the currently valued option (interactions including Session Type × Devaluation: all Fs < 0.27, p > 0.62). This implies that selective satiety induces an immediate general, rather than stimulus-specific, reduction in cue-elicited dopamine signals but that rats need experience of the reinforcer in the new state to fully update learned cue associations.


Mesolimbic Dopamine Encodes Prediction Errors in a State-Dependent Manner.

Papageorgiou GK, Baudonnat M, Cucca F, Walton ME - Cell Rep (2016)

Cue-Elicited Dopamine Release on First Trials of the Session(A) Average dopamine levels in a 5-s window after cue onset on the first food/sucrose solution trial in baselines A and B. Baseline data are divided into “valued” (Val) or “devalued” (Deval) based on which reinforcer the animals had free access to in devaluation A.(B) Average dopamine signals after cue onset on the first food/sucrose solution trial in the baseline and devaluation sessions. Baseline data here are divided up based on which reinforcer the animals had free access to in the subsequent devaluation session.(C) Average dopamine levels in a 2-s post-lever extension window (prior to reward delivery) on the first food or sucrose solution trial, averaged across the devaluation sessions.Levels were significantly reduced on the first devalued trial compared to the first valued trial (∗p < 0.05, ANOVA). All averages indicate mean ± SEM. DA, dopamine.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835543&req=5

fig4: Cue-Elicited Dopamine Release on First Trials of the Session(A) Average dopamine levels in a 5-s window after cue onset on the first food/sucrose solution trial in baselines A and B. Baseline data are divided into “valued” (Val) or “devalued” (Deval) based on which reinforcer the animals had free access to in devaluation A.(B) Average dopamine signals after cue onset on the first food/sucrose solution trial in the baseline and devaluation sessions. Baseline data here are divided up based on which reinforcer the animals had free access to in the subsequent devaluation session.(C) Average dopamine levels in a 2-s post-lever extension window (prior to reward delivery) on the first food or sucrose solution trial, averaged across the devaluation sessions.Levels were significantly reduced on the first devalued trial compared to the first valued trial (∗p < 0.05, ANOVA). All averages indicate mean ± SEM. DA, dopamine.
Mentions: Although these analyses show a rapid influence of selective satiety on dopamine release, it is not clear whether this is purely an experience-dependent effect based on learning the value of the options in the new state or whether dopamine cue signals can update even before the devalued reward is consumed during the session. To examine this, we analyzed dopamine release elicited by the first presentation in the session of both the valued and devalued options (Figure 4A). This revealed an overall attenuation of dopamine release on the initial trial of the devaluation sessions compared to the preceding baseline session (main effect of session type: F(1, 6) = 12.44, p = 0.012, including trial order as a between-subjects factors). However, this reduction was not significantly greater after first presentation of the cue associated with the currently devalued option than after that associated with the currently valued option (interactions including Session Type × Devaluation: all Fs < 0.27, p > 0.62). This implies that selective satiety induces an immediate general, rather than stimulus-specific, reduction in cue-elicited dopamine signals but that rats need experience of the reinforcer in the new state to fully update learned cue associations.

Bottom Line: Mesolimbic dopamine encodes the benefits of a course of action.These changes were rapid and selective, with dopamine release returning to pre-satiation patterns when the animals were re-tested in a standard food-restricted state.Such rapid and selective adaptation of dopamine-associated value signals could provide an important signal to promote efficient foraging for a varied diet.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Psychology, University of Oxford, 9 South Parks Road, Oxford OX1 3UD, UK. Electronic address: georgios.papageorgiou@psy.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus