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Mesolimbic Dopamine Encodes Prediction Errors in a State-Dependent Manner.

Papageorgiou GK, Baudonnat M, Cucca F, Walton ME - Cell Rep (2016)

Bottom Line: Mesolimbic dopamine encodes the benefits of a course of action.These changes were rapid and selective, with dopamine release returning to pre-satiation patterns when the animals were re-tested in a standard food-restricted state.Such rapid and selective adaptation of dopamine-associated value signals could provide an important signal to promote efficient foraging for a varied diet.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Psychology, University of Oxford, 9 South Parks Road, Oxford OX1 3UD, UK. Electronic address: georgios.papageorgiou@psy.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Task Design, Behavioral Performance, and Example Dopamine Signals(A) Schematic of a typical forced trial (“Forced Left”). Arrows between “Levers extend” and “Reward delivered” indicate the transition probabilities following a response on that option (“FOOD” and “SUCROSE SOLUTION” in regular type indicates standard reward; in bold type, they indicate increased reward). RT, response time.(B) Proportion of food choices on choice trials (circles correspond to individual rats).(C and D) Individual example MORE (C) and SWITCH (D) trials. Each panel depicts the recorded current × applied voltage in a pseudocolor plot from 2 s before and 5 s after reward delivery. The upper trace depicts the extract dopamine signal, along with an example cyclic voltammogram identifying the detected current as dopamine.All averages indicate mean ± SEM.
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fig1: Task Design, Behavioral Performance, and Example Dopamine Signals(A) Schematic of a typical forced trial (“Forced Left”). Arrows between “Levers extend” and “Reward delivered” indicate the transition probabilities following a response on that option (“FOOD” and “SUCROSE SOLUTION” in regular type indicates standard reward; in bold type, they indicate increased reward). RT, response time.(B) Proportion of food choices on choice trials (circles correspond to individual rats).(C and D) Individual example MORE (C) and SWITCH (D) trials. Each panel depicts the recorded current × applied voltage in a pseudocolor plot from 2 s before and 5 s after reward delivery. The upper trace depicts the extract dopamine signal, along with an example cyclic voltammogram identifying the detected current as dopamine.All averages indicate mean ± SEM.

Mentions: Food-restricted rats were trained to perform a two-option operant decision-making task where the selection of each option was associated with a particular type of reward (food pellet or sucrose solution) (Figure 1A). Sessions consisted of trials where only one reward type was available (“forced” trials) and others where rats could choose between the two (“choice” trials). After acquiring the task, the rats (n = 8) performed four sessions: two baseline sessions (A and B), each of which preceded a devaluation session (the devalue food session and the devalue sucrose solution session, order counterbalanced across animals) that was identical to the baseline sessions, except that the rats had free access to one of the rewards for an hour before the test session.


Mesolimbic Dopamine Encodes Prediction Errors in a State-Dependent Manner.

Papageorgiou GK, Baudonnat M, Cucca F, Walton ME - Cell Rep (2016)

Task Design, Behavioral Performance, and Example Dopamine Signals(A) Schematic of a typical forced trial (“Forced Left”). Arrows between “Levers extend” and “Reward delivered” indicate the transition probabilities following a response on that option (“FOOD” and “SUCROSE SOLUTION” in regular type indicates standard reward; in bold type, they indicate increased reward). RT, response time.(B) Proportion of food choices on choice trials (circles correspond to individual rats).(C and D) Individual example MORE (C) and SWITCH (D) trials. Each panel depicts the recorded current × applied voltage in a pseudocolor plot from 2 s before and 5 s after reward delivery. The upper trace depicts the extract dopamine signal, along with an example cyclic voltammogram identifying the detected current as dopamine.All averages indicate mean ± SEM.
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4835543&req=5

fig1: Task Design, Behavioral Performance, and Example Dopamine Signals(A) Schematic of a typical forced trial (“Forced Left”). Arrows between “Levers extend” and “Reward delivered” indicate the transition probabilities following a response on that option (“FOOD” and “SUCROSE SOLUTION” in regular type indicates standard reward; in bold type, they indicate increased reward). RT, response time.(B) Proportion of food choices on choice trials (circles correspond to individual rats).(C and D) Individual example MORE (C) and SWITCH (D) trials. Each panel depicts the recorded current × applied voltage in a pseudocolor plot from 2 s before and 5 s after reward delivery. The upper trace depicts the extract dopamine signal, along with an example cyclic voltammogram identifying the detected current as dopamine.All averages indicate mean ± SEM.
Mentions: Food-restricted rats were trained to perform a two-option operant decision-making task where the selection of each option was associated with a particular type of reward (food pellet or sucrose solution) (Figure 1A). Sessions consisted of trials where only one reward type was available (“forced” trials) and others where rats could choose between the two (“choice” trials). After acquiring the task, the rats (n = 8) performed four sessions: two baseline sessions (A and B), each of which preceded a devaluation session (the devalue food session and the devalue sucrose solution session, order counterbalanced across animals) that was identical to the baseline sessions, except that the rats had free access to one of the rewards for an hour before the test session.

Bottom Line: Mesolimbic dopamine encodes the benefits of a course of action.These changes were rapid and selective, with dopamine release returning to pre-satiation patterns when the animals were re-tested in a standard food-restricted state.Such rapid and selective adaptation of dopamine-associated value signals could provide an important signal to promote efficient foraging for a varied diet.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental Psychology, University of Oxford, 9 South Parks Road, Oxford OX1 3UD, UK. Electronic address: georgios.papageorgiou@psy.ox.ac.uk.

No MeSH data available.


Related in: MedlinePlus