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Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition.

Ishii K, Hosokawa C, Hyodo T, Sakaguchi K, Usami K, Shimamoto K, Hosono M, Yamazoe Y, Murakami T - Ann Nucl Med (2014)

Bottom Line: There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition.In the DLB group the parietotemporal and occipital metabolism were significantly lower than those in the AD group but there was no difference between the posterior cingulate hypometabolism between DLB and AD groups.There were no differences in regional glucose metabolism between PiB positive and negative DLB patients.

View Article: PubMed Central - PubMed

Affiliation: Neurocognitive Disorders Center, Kinki University Hospital, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan, ishii@med.kindai.ac.jp.

ABSTRACT

Purpose: There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition. The aim of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the DLB brain and measure the degree of regional hypometabolism.

Methods: Ten consecutive subjects with DLB and 10 AD patients who underwent both Pittsburgh compound B (PiB)-PET and (18)F-fluoro-2-deoxyglucose (FDG)-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG- and PiB-PET images.

Results: All AD patients and five DLB patients showed amyloid deposits (PiB positive). In the DLB group the parietotemporal and occipital metabolism were significantly lower than those in the AD group but there was no difference between the posterior cingulate hypometabolism between DLB and AD groups. There were no differences in regional glucose metabolism between PiB positive and negative DLB patients.

Conclusions: In the DLB brain, it is suggested that decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area and the degree of parietotemporal and occipital hypometabolism in DLB brain is much larger than that in AD brain.

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More increased PiB uptake in PiB positive DLB groups compared to PiB negative DLB group groups. In the PiB positive group, PiB accumulation in the frontal, parietal, and posterior cingulate and precuneus cortices were significantly larger than those in the PiB negative group
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Fig2: More increased PiB uptake in PiB positive DLB groups compared to PiB negative DLB group groups. In the PiB positive group, PiB accumulation in the frontal, parietal, and posterior cingulate and precuneus cortices were significantly larger than those in the PiB negative group

Mentions: All patients with AD and five patients with DLB were PiB positive, one patient with DLB was PiB questionable, and four patients with DLB were PiB negative. In this study, a PiB questionable subject was included in the PiB negative group because in the majority of cortices there was no PiB uptake, except for the right temporal gyri. The mean MMSE score of PiB positive DLB group was 24.0 ± 2.3 and the mean MMSE score of PiB negative DLB group was 23.4 ± 5.1: there was no significant difference (p = 0.39). The right temporal and bilateral occipital metabolisms in the DLB group were significantly lower than those of the AD group (Fig. 1). In DLB patients, there were no significant differences in regional glucose metabolism between PiB positive and negative patients, and as a matter of course frontal, parietal and posterior cingulate, and precuneus PiB uptakes in the PiB positive group were significantly higher than those of the PiB negative group (Fig. 2).Fig. 1


Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition.

Ishii K, Hosokawa C, Hyodo T, Sakaguchi K, Usami K, Shimamoto K, Hosono M, Yamazoe Y, Murakami T - Ann Nucl Med (2014)

More increased PiB uptake in PiB positive DLB groups compared to PiB negative DLB group groups. In the PiB positive group, PiB accumulation in the frontal, parietal, and posterior cingulate and precuneus cortices were significantly larger than those in the PiB negative group
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4835511&req=5

Fig2: More increased PiB uptake in PiB positive DLB groups compared to PiB negative DLB group groups. In the PiB positive group, PiB accumulation in the frontal, parietal, and posterior cingulate and precuneus cortices were significantly larger than those in the PiB negative group
Mentions: All patients with AD and five patients with DLB were PiB positive, one patient with DLB was PiB questionable, and four patients with DLB were PiB negative. In this study, a PiB questionable subject was included in the PiB negative group because in the majority of cortices there was no PiB uptake, except for the right temporal gyri. The mean MMSE score of PiB positive DLB group was 24.0 ± 2.3 and the mean MMSE score of PiB negative DLB group was 23.4 ± 5.1: there was no significant difference (p = 0.39). The right temporal and bilateral occipital metabolisms in the DLB group were significantly lower than those of the AD group (Fig. 1). In DLB patients, there were no significant differences in regional glucose metabolism between PiB positive and negative patients, and as a matter of course frontal, parietal and posterior cingulate, and precuneus PiB uptakes in the PiB positive group were significantly higher than those of the PiB negative group (Fig. 2).Fig. 1

Bottom Line: There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition.In the DLB group the parietotemporal and occipital metabolism were significantly lower than those in the AD group but there was no difference between the posterior cingulate hypometabolism between DLB and AD groups.There were no differences in regional glucose metabolism between PiB positive and negative DLB patients.

View Article: PubMed Central - PubMed

Affiliation: Neurocognitive Disorders Center, Kinki University Hospital, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan, ishii@med.kindai.ac.jp.

ABSTRACT

Purpose: There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition. The aim of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the DLB brain and measure the degree of regional hypometabolism.

Methods: Ten consecutive subjects with DLB and 10 AD patients who underwent both Pittsburgh compound B (PiB)-PET and (18)F-fluoro-2-deoxyglucose (FDG)-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG- and PiB-PET images.

Results: All AD patients and five DLB patients showed amyloid deposits (PiB positive). In the DLB group the parietotemporal and occipital metabolism were significantly lower than those in the AD group but there was no difference between the posterior cingulate hypometabolism between DLB and AD groups. There were no differences in regional glucose metabolism between PiB positive and negative DLB patients.

Conclusions: In the DLB brain, it is suggested that decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area and the degree of parietotemporal and occipital hypometabolism in DLB brain is much larger than that in AD brain.

Show MeSH
Related in: MedlinePlus