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Brown Adipose Tissue Is Linked to a Distinct Thermoregulatory Response to Mild Cold in People.

Chondronikola M, Volpi E, Børsheim E, Chao T, Porter C, Annamalai P, Yfanti C, Labbe SM, Hurren NM, Malagaris I, Cesani F, Sidossis LS - Front Physiol (2016)

Bottom Line: BAT volume was associated with the cold-induced change in core temperature (p = 0.01) even after adjustment for age and adiposity.BAT+: 19.8 ± 0.3°C, p = 0.035) without shivering.The cold-induced change in core temperature (r = 0.79, p = 0.001) and supraclavicular temperature (r = 0.58, p = 0.014) correlated with BAT volume, suggesting that these non-invasive measures can be potentially used as surrogate markers of BAT when other methods to detect BAT are not available or their use is not warranted.

View Article: PubMed Central - PubMed

Affiliation: Metabolism Unit, Shriners Hospitals for Children-GalvestonTX, USA; Department of Preventive Medicine and Community Health, University of Texas Medical BranchGalveston, TX, USA; Division of Rehabilitation Sciences, Department of Nutrition and Metabolism, University of Texas Medical BranchGalveston, TX, USA; Department of Nutrition and Dietetics, Harokopio University of AthensGreece.

ABSTRACT
Brown adipose tissue (BAT) plays an important role in thermoregulation in rodents. Its role in temperature homeostasis in people is less studied. To this end, we recruited 18 men [8 subjects with no/minimal BAT activity (BAT-) and 10 with pronounced BAT activity (BAT+)]. Each volunteer participated in a 6 h, individualized, non-shivering cold exposure protocol. BAT was quantified using positron emission tomography/computed tomography. Body core and skin temperatures were measured using a telemetric pill and wireless thermistors, respectively. Core body temperature decreased during cold exposure in the BAT- group only (-0.34°C, 95% CI: -0.6 to -0.1, p = 0.03), while the cold-induced change in core temperature was significantly different between BAT+ and BAT- subjects (BAT+ vs. BAT-, 0.43°C, 95% CI: 0.20-0.65, p = 0.0014). BAT volume was associated with the cold-induced change in core temperature (p = 0.01) even after adjustment for age and adiposity. Compared to the BAT- group, BAT+ subjects tolerated a lower ambient temperature (BAT-: 20.6 ± 0.3°C vs. BAT+: 19.8 ± 0.3°C, p = 0.035) without shivering. The cold-induced change in core temperature (r = 0.79, p = 0.001) and supraclavicular temperature (r = 0.58, p = 0.014) correlated with BAT volume, suggesting that these non-invasive measures can be potentially used as surrogate markers of BAT when other methods to detect BAT are not available or their use is not warranted. These results demonstrate a physiologically significant role for BAT in thermoregulation in people. This trial has been registered with Clinaltrials.gov: NCT01791114 (https://clinicaltrials.gov/ct2/show/NCT01791114).

No MeSH data available.


Related in: MedlinePlus

Brown adipose tissue (BAT) and body temperature. (A) Cold-induced change in core temperature in subjects with detectable BAT (BAT+) and without detectable BAT (BAT−). **p = 0.0014 using Student's t-test, *p = 0.03 using one sample t-test. (B) Correlation of BAT volume with the change in body core temperature using Pearson's r. (C) Cold-induced change in supraclavicular skin temperature in BAT+ and BAT− subjects. **p = 0.007 using by one sample t-test, *p = 0.03 using Student's t-test. (D) Correlation of BAT volume with the change in supraclavicular skin body temperature using Pearson's r. The data are means and standard deviations. The dashed lines represent 95% confidence intervals.
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Figure 3: Brown adipose tissue (BAT) and body temperature. (A) Cold-induced change in core temperature in subjects with detectable BAT (BAT+) and without detectable BAT (BAT−). **p = 0.0014 using Student's t-test, *p = 0.03 using one sample t-test. (B) Correlation of BAT volume with the change in body core temperature using Pearson's r. (C) Cold-induced change in supraclavicular skin temperature in BAT+ and BAT− subjects. **p = 0.007 using by one sample t-test, *p = 0.03 using Student's t-test. (D) Correlation of BAT volume with the change in supraclavicular skin body temperature using Pearson's r. The data are means and standard deviations. The dashed lines represent 95% confidence intervals.

Mentions: Core body temperature decreased after 5 h of CE only in the BAT− group (−0.34°C, 95% CI: −0.6 to −0.1, p = 0.03) (Figure 3A). Interestingly, the cold-induced change in core temperature was significantly different between BAT+ and BAT− subjects (0.43°C, 95% CI: 0.20–0.65, p = 0.0014), while BAT volume significantly correlated with cold-induced change in core temperature (r = 0.79, p = 0.001, Figure 3B). No correlation was noted between muscle activity (measured as the mean skeletal muscle SUV for glucose during CE in the m. pectoralis major and m. vastus lateralis) and change in core temperature at the 5 h of CE (Table 2) or any other time point (data not shown).


Brown Adipose Tissue Is Linked to a Distinct Thermoregulatory Response to Mild Cold in People.

Chondronikola M, Volpi E, Børsheim E, Chao T, Porter C, Annamalai P, Yfanti C, Labbe SM, Hurren NM, Malagaris I, Cesani F, Sidossis LS - Front Physiol (2016)

Brown adipose tissue (BAT) and body temperature. (A) Cold-induced change in core temperature in subjects with detectable BAT (BAT+) and without detectable BAT (BAT−). **p = 0.0014 using Student's t-test, *p = 0.03 using one sample t-test. (B) Correlation of BAT volume with the change in body core temperature using Pearson's r. (C) Cold-induced change in supraclavicular skin temperature in BAT+ and BAT− subjects. **p = 0.007 using by one sample t-test, *p = 0.03 using Student's t-test. (D) Correlation of BAT volume with the change in supraclavicular skin body temperature using Pearson's r. The data are means and standard deviations. The dashed lines represent 95% confidence intervals.
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Figure 3: Brown adipose tissue (BAT) and body temperature. (A) Cold-induced change in core temperature in subjects with detectable BAT (BAT+) and without detectable BAT (BAT−). **p = 0.0014 using Student's t-test, *p = 0.03 using one sample t-test. (B) Correlation of BAT volume with the change in body core temperature using Pearson's r. (C) Cold-induced change in supraclavicular skin temperature in BAT+ and BAT− subjects. **p = 0.007 using by one sample t-test, *p = 0.03 using Student's t-test. (D) Correlation of BAT volume with the change in supraclavicular skin body temperature using Pearson's r. The data are means and standard deviations. The dashed lines represent 95% confidence intervals.
Mentions: Core body temperature decreased after 5 h of CE only in the BAT− group (−0.34°C, 95% CI: −0.6 to −0.1, p = 0.03) (Figure 3A). Interestingly, the cold-induced change in core temperature was significantly different between BAT+ and BAT− subjects (0.43°C, 95% CI: 0.20–0.65, p = 0.0014), while BAT volume significantly correlated with cold-induced change in core temperature (r = 0.79, p = 0.001, Figure 3B). No correlation was noted between muscle activity (measured as the mean skeletal muscle SUV for glucose during CE in the m. pectoralis major and m. vastus lateralis) and change in core temperature at the 5 h of CE (Table 2) or any other time point (data not shown).

Bottom Line: BAT volume was associated with the cold-induced change in core temperature (p = 0.01) even after adjustment for age and adiposity.BAT+: 19.8 ± 0.3°C, p = 0.035) without shivering.The cold-induced change in core temperature (r = 0.79, p = 0.001) and supraclavicular temperature (r = 0.58, p = 0.014) correlated with BAT volume, suggesting that these non-invasive measures can be potentially used as surrogate markers of BAT when other methods to detect BAT are not available or their use is not warranted.

View Article: PubMed Central - PubMed

Affiliation: Metabolism Unit, Shriners Hospitals for Children-GalvestonTX, USA; Department of Preventive Medicine and Community Health, University of Texas Medical BranchGalveston, TX, USA; Division of Rehabilitation Sciences, Department of Nutrition and Metabolism, University of Texas Medical BranchGalveston, TX, USA; Department of Nutrition and Dietetics, Harokopio University of AthensGreece.

ABSTRACT
Brown adipose tissue (BAT) plays an important role in thermoregulation in rodents. Its role in temperature homeostasis in people is less studied. To this end, we recruited 18 men [8 subjects with no/minimal BAT activity (BAT-) and 10 with pronounced BAT activity (BAT+)]. Each volunteer participated in a 6 h, individualized, non-shivering cold exposure protocol. BAT was quantified using positron emission tomography/computed tomography. Body core and skin temperatures were measured using a telemetric pill and wireless thermistors, respectively. Core body temperature decreased during cold exposure in the BAT- group only (-0.34°C, 95% CI: -0.6 to -0.1, p = 0.03), while the cold-induced change in core temperature was significantly different between BAT+ and BAT- subjects (BAT+ vs. BAT-, 0.43°C, 95% CI: 0.20-0.65, p = 0.0014). BAT volume was associated with the cold-induced change in core temperature (p = 0.01) even after adjustment for age and adiposity. Compared to the BAT- group, BAT+ subjects tolerated a lower ambient temperature (BAT-: 20.6 ± 0.3°C vs. BAT+: 19.8 ± 0.3°C, p = 0.035) without shivering. The cold-induced change in core temperature (r = 0.79, p = 0.001) and supraclavicular temperature (r = 0.58, p = 0.014) correlated with BAT volume, suggesting that these non-invasive measures can be potentially used as surrogate markers of BAT when other methods to detect BAT are not available or their use is not warranted. These results demonstrate a physiologically significant role for BAT in thermoregulation in people. This trial has been registered with Clinaltrials.gov: NCT01791114 (https://clinicaltrials.gov/ct2/show/NCT01791114).

No MeSH data available.


Related in: MedlinePlus